-
1
-
-
0036075924
-
Clinical pharmacokinetics and pharmacodynamics of repaglinide
-
V. Hatorp Clinical pharmacokinetics and pharmacodynamics of repaglinide Clin Pharmacokinet 41 2002 471 483
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 471-483
-
-
Hatorp, V.1
-
2
-
-
0031593457
-
Bioavailability of repaglinide, a novel antidiabetic agent, administered orally in tablet or solution form or intravenously in healthy male volunteers
-
V. Hatorp, S. Oliver, C.A. Su Bioavailability of repaglinide, a novel antidiabetic agent, administered orally in tablet or solution form or intravenously in healthy male volunteers Int J Clin Pharmacol Ther 36 1998 636 641
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, pp. 636-641
-
-
Hatorp, V.1
Oliver, S.2
Su, C.A.3
-
3
-
-
0032830946
-
Absorption, metabolism and excretion of a single oral dose of (14)C-repaglinide during repaglinide multiple dosing
-
P.N. van Heiningen, V. Hatorp, K. Kramer Nielsen, K.T. Hansen, J.J. van Lier, N.C. De Merbel Absorption, metabolism and excretion of a single oral dose of (14)C-repaglinide during repaglinide multiple dosing Eur J Clin Pharmacol 55 1999 521 525
-
(1999)
Eur J Clin Pharmacol
, vol.55
, pp. 521-525
-
-
Van Heiningen, P.N.1
Hatorp, V.2
Kramer Nielsen, K.3
Hansen, K.T.4
Van Lier, J.J.5
De Merbel, N.C.6
-
4
-
-
0042318871
-
CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide
-
T.B. Bidstrup, I. Bjørnsdottir, U.G. Sidelmann, M.S. Thomsen, K.T. Hansen CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide Br J Clin Pharmacol 56 2003 305 314
-
(2003)
Br J Clin Pharmacol
, vol.56
, pp. 305-314
-
-
Bidstrup, T.B.1
Bjørnsdottir, I.2
Sidelmann, U.G.3
Thomsen, M.S.4
Hansen, K.T.5
-
5
-
-
0141706934
-
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide
-
M. Niemi, J.B. Leathart, M. Neuvonen, J.T. Backman, A.K. Daly, P.J. Neuvonen Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide Clin Pharmacol Ther 74 2003 380 387
-
(2003)
Clin Pharmacol Ther
, vol.74
, pp. 380-387
-
-
Niemi, M.1
Leathart, J.B.2
Neuvonen, M.3
Backman, J.T.4
Daly, A.K.5
Neuvonen, P.J.6
-
6
-
-
0034912196
-
The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide
-
M. Niemi, P.J. Neuvonen, K.T. Kivistö The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide Clin Pharmacol Ther 70 2001 58 65
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 58-65
-
-
Niemi, M.1
Neuvonen, P.J.2
Kivistö, K.T.3
-
7
-
-
0037627707
-
Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: Potentially hazardous interaction between gemfibrozil and repaglinide
-
M. Niemi, J.T. Backman, M. Neuvonen, P.J. Neuvonen Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide potentially hazardous interaction between gemfibrozil and repaglinide Diabetologia 46 2003 347 351
-
(2003)
Diabetologia
, vol.46
, pp. 347-351
-
-
Niemi, M.1
Backman, J.T.2
Neuvonen, M.3
Neuvonen, P.J.4
-
8
-
-
0028357256
-
Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole
-
K.T. Olkkola, J.T. Backman, P.J. Neuvonen Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole Clin Pharmacol Ther 55 1994 481 485
-
(1994)
Clin Pharmacol Ther
, vol.55
, pp. 481-485
-
-
Olkkola, K.T.1
Backman, J.T.2
Neuvonen, P.J.3
-
9
-
-
0031696409
-
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
-
J.C. Gorski, D.R. Jones, B.D. Haehner-Daniels, M.A. Hamman, E.M. O'Mara Jr, S.D. Hall The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin Clin Pharmacol Ther 64 1998 133 143
-
(1998)
Clin Pharmacol Ther
, vol.64
, pp. 133-143
-
-
Gorski, J.C.1
Jones, D.R.2
Haehner-Daniels, B.D.3
Hamman, M.A.4
O'Mara Jr., E.M.5
Hall, S.D.6
-
10
-
-
0036135397
-
Interaction of common azole antifungals with P glycoprotein
-
E.J. Wang, K. Lew, C.N. Casciano, R.P. Clement, W.W. Johnson Interaction of common azole antifungals with P glycoprotein Antimicrob Agents Chemother 46 2002 160 165
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 160-165
-
-
Wang, E.J.1
Lew, K.2
Casciano, C.N.3
Clement, R.P.4
Johnson, W.W.5
-
11
-
-
0031845356
-
Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
-
H. Wakasugi, I. Yano, T. Ito, T. Hashida, T. Futami, R. Nohara Effect of clarithromycin on renal excretion of digoxin interaction with P-glycoprotein Clin Pharmacol Ther 64 1998 123 128
-
(1998)
Clin Pharmacol Ther
, vol.64
, pp. 123-128
-
-
Wakasugi, H.1
Yano, I.2
Ito, T.3
Hashida, T.4
Futami, T.5
Nohara, R.6
-
12
-
-
3242785620
-
Importance of P-glycoprotein at blood-tissue barriers
-
M.F. Fromm Importance of P-glycoprotein at blood-tissue barriers Trends Pharmacol Sci 25 2004 423 429
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 423-429
-
-
Fromm, M.F.1
-
13
-
-
1942487810
-
The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects
-
M. Niemi, L.I. Kajosaari, M. Neuvonen, J.T. Backman, P.J. Neuvonen The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects Br J Clin Pharmacol 57 2004 441 447
-
(2004)
Br J Clin Pharmacol
, vol.57
, pp. 441-447
-
-
Niemi, M.1
Kajosaari, L.I.2
Neuvonen, M.3
Backman, J.T.4
Neuvonen, P.J.5
-
14
-
-
0036892714
-
Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes
-
J.S. Wang, M. Neuvonen, X. Wen, J.T. Backman, P.J. Neuvonen Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes Drug Metab Dispos 30 2002 1352 1356
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1352-1356
-
-
Wang, J.S.1
Neuvonen, M.2
Wen, X.3
Backman, J.T.4
Neuvonen, P.J.5
-
15
-
-
4644301418
-
Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
-
Y. Shitara, M. Hirano, H. Sato, Y. Sugiyama Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil J Pharmacol Exp Ther 311 2004 228 236
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 228-236
-
-
Shitara, Y.1
Hirano, M.2
Sato, H.3
Sugiyama, Y.4
-
16
-
-
1242272736
-
Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
-
B. Hagenbuch, P.J. Meier Organic anion transporting polypeptides of the OATP/SLC21 family phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties Pflugers Arch 447 2004 653 665
-
(2004)
Pflugers Arch
, vol.447
, pp. 653-665
-
-
Hagenbuch, B.1
Meier, P.J.2
-
17
-
-
0037328994
-
Pharmacogenetics of the major polymorphic metabolizing enzymes
-
A.K. Daly Pharmacogenetics of the major polymorphic metabolizing enzymes Fundam Clin Pharmacol 17 2003 27 41
-
(2003)
Fundam Clin Pharmacol
, vol.17
, pp. 27-41
-
-
Daly, A.K.1
-
18
-
-
9444228347
-
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism
-
W. Huang, Y.S. Lin, D.J. McConn II, J.C. Calamia, R.A. Totah, N. Isoherranen Evidence of significant contribution from CYP3A5 to hepatic drug metabolism Drug Metab Dispos 32 2004 1434 1445
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1434-1445
-
-
Huang, W.1
Lin, Y.S.2
McConn II, D.J.3
Calamia, J.C.4
Totah, R.A.5
Isoherranen, N.6
-
19
-
-
0035071598
-
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
-
P. Kuehl, J. Zhang, Y. Lin, J. Lamba, M. Assem, J. Schuetz Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression Nat Genet 27 2001 383 391
-
(2001)
Nat Genet
, vol.27
, pp. 383-391
-
-
Kuehl, P.1
Zhang, J.2
Lin, Y.3
Lamba, J.4
Assem, M.5
Schuetz, J.6
-
20
-
-
0038713368
-
CYP3A5 phenotype-genotype correlations in a British population
-
B.P. King, J.B. Leathart, E. Mutch, F.M. Williams, A.K. Daly CYP3A5 phenotype-genotype correlations in a British population Br J Clin Pharmacol 55 2003 625 629
-
(2003)
Br J Clin Pharmacol
, vol.55
, pp. 625-629
-
-
King, B.P.1
Leathart, J.B.2
Mutch, E.3
Williams, F.M.4
Daly, A.K.5
-
21
-
-
1642523162
-
Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
-
C. Marzolini, E. Paus, T. Buclin, R.B. Kim Polymorphisms in human MDR1 (P-glycoprotein) recent advances and clinical relevance Clin Pharmacol Ther 75 2004 13 33
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 13-33
-
-
Marzolini, C.1
Paus, E.2
Buclin, T.3
Kim, R.B.4
-
23
-
-
0035929574
-
Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
-
R.G. Tirona, B.F. Leake, G. Merino, R.B. Kim Polymorphisms in OATP-C identification of multiple allelic variants associated with altered transport activity among European- and African-Americans J Biol Chem 276 2001 35669 35675
-
(2001)
J Biol Chem
, vol.276
, pp. 35669-35675
-
-
Tirona, R.G.1
Leake, B.F.2
Merino, G.3
Kim, R.B.4
-
24
-
-
0038209381
-
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
-
Y. Nishizato, I. Ieiri, H. Suzuki, M. Kimura, K. Kawabata, T. Hirota Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes consequences for pravastatin pharmacokinetics Clin Pharmacol Ther 73 2003 554 565
-
(2003)
Clin Pharmacol Ther
, vol.73
, pp. 554-565
-
-
Nishizato, Y.1
Ieiri, I.2
Suzuki, H.3
Kimura, M.4
Kawabata, K.5
Hirota, T.6
-
25
-
-
2042469487
-
Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics
-
J. Mwinyi, A. Johne, S. Bauer, I. Roots, T. Gerloff Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics Clin Pharmacol Ther 75 2004 415 421
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 415-421
-
-
Mwinyi, J.1
Johne, A.2
Bauer, S.3
Roots, I.4
Gerloff, T.5
-
26
-
-
3242808852
-
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
-
M. Niemi, E. Schaeffeler, T. Lang, M.F. Fromm, M. Neuvonen, C. Kyrklund High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1) Pharmacogenetics 14 2004 429 440
-
(2004)
Pharmacogenetics
, vol.14
, pp. 429-440
-
-
Niemi, M.1
Schaeffeler, E.2
Lang, T.3
Fromm, M.F.4
Neuvonen, M.5
Kyrklund, C.6
-
27
-
-
4744349916
-
Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide
-
L.I. Kajosaari, J.T. Backman, M. Neuvonen, J. Laitila, P.J. Neuvonen Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide Br J Clin Pharmacol 58 2004 390 396
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 390-396
-
-
Kajosaari, L.I.1
Backman, J.T.2
Neuvonen, M.3
Laitila, J.4
Neuvonen, P.J.5
-
28
-
-
18644367631
-
Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease
-
T. Furuno, M.T. Landi, M. Ceroni, N. Caporaso, I. Bernucci, G. Nappi Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease Pharmacogenetics 12 2002 529 534
-
(2002)
Pharmacogenetics
, vol.12
, pp. 529-534
-
-
Furuno, T.1
Landi, M.T.2
Ceroni, M.3
Caporaso, N.4
Bernucci, I.5
Nappi, G.6
-
29
-
-
0036881149
-
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene
-
A. Johne, K. Kopke, T. Gerloff, I. Mai, S. Rietbrock, C. Meisel Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene Clin Pharmacol Ther 72 2002 584 594
-
(2002)
Clin Pharmacol Ther
, vol.72
, pp. 584-594
-
-
Johne, A.1
Kopke, K.2
Gerloff, T.3
Mai, I.4
Rietbrock, S.5
Meisel, C.6
-
30
-
-
0037310871
-
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin a
-
Y. Shitara, T. Itoh, H. Sato, A.P. Li, Y. Sugiyama Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A J Pharmacol Exp Ther 304 2003 610 616
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 610-616
-
-
Shitara, Y.1
Itoh, T.2
Sato, H.3
Li, A.P.4
Sugiyama, Y.5
-
31
-
-
1642523136
-
Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression
-
M. Hedman, P.J. Neuvonen, M. Neuvonen, C. Holmberg, M. Antikainen Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression Clin Pharmacol Ther 75 2004 101 109
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 101-109
-
-
Hedman, M.1
Neuvonen, P.J.2
Neuvonen, M.3
Holmberg, C.4
Antikainen, M.5
-
32
-
-
0034495168
-
Clinical pharmacokinetics of pravastatin: Mechanisms of pharmacokinetic events
-
T. Hatanaka Clinical pharmacokinetics of pravastatin mechanisms of pharmacokinetic events Clin Pharmacokinet 39 2000 397 412
-
(2000)
Clin Pharmacokinet
, vol.39
, pp. 397-412
-
-
Hatanaka, T.1
-
33
-
-
3542992126
-
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
-
S.G. Simonson, A. Raza, P.D. Martin, P.D. Mitchell, J.A. Jarcho, C.D. Brown Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine Clin Pharmacol Ther 76 2004 167 177
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 167-177
-
-
Simonson, S.G.1
Raza, A.2
Martin, P.D.3
Mitchell, P.D.4
Jarcho, J.A.5
Brown, C.D.6
-
34
-
-
0034791777
-
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
-
D. Dai, D.C. Zeldin, J.A. Blaisdell, B. Chanas, S.J. Coulter, B.I. Ghanayem Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid Pharmacogenetics 11 2001 597 607
-
(2001)
Pharmacogenetics
, vol.11
, pp. 597-607
-
-
Dai, D.1
Zeldin, D.C.2
Blaisdell, J.A.3
Chanas, B.4
Coulter, S.J.5
Ghanayem, B.I.6
-
35
-
-
0035214173
-
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism
-
A. Soyama, Y. Saito, N. Hanioka, N. Murayama, O. Nakajima, N. Katori Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism Biol Pharm Bull 24 2001 1427 1430
-
(2001)
Biol Pharm Bull
, vol.24
, pp. 1427-1430
-
-
Soyama, A.1
Saito, Y.2
Hanioka, N.3
Murayama, N.4
Nakajima, O.5
Katori, N.6
-
36
-
-
0036889666
-
CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes
-
N. Bahadur, J.B. Leathart, E. Mutch, D. Steimel-Crespi, S.A. Dunn, R. Gilissen CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes Biochem Pharmacol 64 2002 1579 1589
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1579-1589
-
-
Bahadur, N.1
Leathart, J.B.2
Mutch, E.3
Steimel-Crespi, D.4
Dunn, S.A.5
Gilissen, R.6
-
37
-
-
3543012028
-
Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms
-
E. Garcia-Martin, C. Martinez, B. Tabares, J. Frias, J.A. Agundez Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms Clin Pharmacol Ther 76 2004 119 127
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 119-127
-
-
Garcia-Martin, E.1
Martinez, C.2
Tabares, B.3
Frias, J.4
Agundez, J.A.5
-
38
-
-
0035806748
-
Frequency of C3435T polymorphism of MDR1 gene in African people
-
E. Schaeffeler, M. Eichelbaum, U. Brinkmann, A. Penger, S. Asante-Poku, U.M. Zanger Frequency of C3435T polymorphism of MDR1 gene in African people Lancet 358 2001 383 384
-
(2001)
Lancet
, vol.358
, pp. 383-384
-
-
Schaeffeler, E.1
Eichelbaum, M.2
Brinkmann, U.3
Penger, A.4
Asante-Poku, S.5
Zanger, U.M.6
-
39
-
-
1942421704
-
Genomic evidence for recent positive selection at the human MDR1 gene locus
-
K. Tang, L.P. Wong, E.J. Lee, S.S. Chong, C.G. Lee Genomic evidence for recent positive selection at the human MDR1 gene locus Hum Mol Genet 13 2004 783 797
-
(2004)
Hum Mol Genet
, vol.13
, pp. 783-797
-
-
Tang, K.1
Wong, L.P.2
Lee, E.J.3
Chong, S.S.4
Lee, C.G.5
|