Impact of nonspecific binding to microsomes and phospholipid on the inhibition of cytochrome P4502D6: Implications for relating in vitro inhibition data to in vivo drug interactions

Drug Metabolism and Disposition

Volumn 31, Issue 5, 2003, Pages 606-611

  Margolis, Jeannine M ^a   Obach, R Scott ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; BUFURALOL 1' HYDROXYLASE; CYTOCHROME P450 2D6; EZLOPITANT; FLUOXETINE; IMIPRAMINE; OXYGENASE; PHOSPHOLIPID; QUINIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; EQUILIBRIUM DIALYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BENZYLAMINES; BICYCLO COMPOUNDS, HETEROCYCLIC; CYTOCHROME P-450 CYP2D6; DRUG INTERACTIONS; ENZYME INHIBITORS; ETHANOLAMINES; FLUOXETINE; HUMANS; IMIPRAMINE; MICROSOMES; PHOSPHOLIPIDS; PROTEIN BINDING; QUINIDINE;

ANIMALIA;

EID: 0037403747     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.5.606     Document Type: Conference Paper

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