In vitro cytochrome P450 inhibition and induction

Current Drug Metabolism

Volumn 9, Issue 9, 2008, Pages 928-939

  Walsky, Robert L ^a   Boldt, Sherri E ^a  

^a PFIZER INC   (United States)

Author keywords

Cytochrome P450; Hepatocyte; Induction; Inhibition; Mass spectrometry; Mechanism based inactivation; Time dependent inhibition

Indexed keywords

AMFEBUTAMONE; AMODIAQUINE; BUFURALOL; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DICLOFENAC; DRUG METABOLIZING ENZYME; FELODIPINE; MEPHENYTOIN; MESSENGER RNA; MIDAZOLAM; NICOTINE; NIFEDIPINE; OMEPRAZOLE; PACLITAXEL; PHENACETIN; TACRINE; TESTOSTERONE; TOLBUTAMIDE; WARFARIN; DRUG; ENZYME INHIBITOR;

BIOLUMINESCENCE; CELL ASSAY; COMPETITIVE INHIBITION; CRYOPRESERVATION; CYTOTOXICITY TEST; DRUG ACTIVITY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME SUBSTRATE; FLUORESCENCE ANALYSIS; HUMAN; IC 50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MASS SPECTROMETRY; PROTEIN BINDING; PROTEIN EXPRESSION; RADIOMETRY; REVIEW; RNA ISOLATION; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; STANDARD;

ANIMALS; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; KINETICS; PHARMACEUTICAL PREPARATIONS; REFERENCE STANDARDS; RNA, MESSENGER;

EID: 60749119589     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008786485128     Document Type: Review

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