Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs

Current Drug Metabolism

Volumn 8, Issue 7, 2007, Pages 685-693

  Galetin, Aleksandra ^a   Hinton, Laura K ^a   Burt, Howard ^a   Obach, R Scott ^b   Houston, J Brian ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

CYP3A4; Drug drug interactions; Enzyme inhibition; Intestinal first pass

Indexed keywords

ALPRAZOLAM; ATENOLOL; ATORVASTATIN; BUSPIRONE; CIMETIDINE; CITALOPRAM; CLARITHROMYCIN; CYCLOSPORIN; CYTOCHROME P450 3A4; DILTIAZEM; DISULFIRAM; ERYTHROMYCIN; FELODIPINE; FLUCONAZOLE; FLUOXETINE; ITRACONAZOLE; KETOCONAZOLE; LIVER ENZYME; MIDAZOLAM; NIFEDIPINE; QUINIDINE; RITONAVIR; SAQUINAVIR; SERTRALINE; SIMVASTATIN; TACROLIMUS; TRIAZOLAM; UNINDEXED DRUG; VERAPAMIL; VORICONAZOLE;

AREA UNDER THE CURVE; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG POTENCY; ENZYME INHIBITION; FIRST PASS EFFECT; GRAPEFRUIT JUICE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTESTINE BLOOD FLOW; INTESTINE FUNCTION; INTESTINE WALL; MODEL; NONHUMAN; PREDICTION; REVIEW; SENSITIVITY ANALYSIS;

BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INHIBITORS; FORECASTING; HUMANS; INTESTINES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS;

EID: 35348880290     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007782109805     Document Type: Review

References (61)

1. Paine, M.F.; Khalighi, M.; Fisher, J.M.; Shen, D.D.; Kunze, K.L.; Marsh, C.L.; Perkins, J.D. and Thummel, K.E. (1997) J. Pharmacol. Exp. Ther., 283, 1552-1562.
2. Obach, R.S.; Zhang, Q-Y.; Dunbar, D. and Kaminsky, L.S. (2001) Drug Metab. Dispos., 29, 347-352.
3. von, Richter, O.; Burk, O.; Fromm, M.F.; Thon, K.P.; Eichelbaum, M. and Kivisto, K.T. (2004) Clin. Pharmacol. Ther., 75, 172-183.
4. Galetin, A. and Houston, J.B. (2006) J. Pharmacol. Exp. Ther., 318, 1220-1229.
5. Olkkola, K.T.; Ahonen, J. and Neuvonen, P.J. (1996) Anesth. Analg., 82, 511-516.
6. Tsunoda, S.M.; Velez, R.L.; von, Moltke, L.L. and Greenblatt, D.J. (1999) Clin. Pharmacol. Ther., 66, 461-471.
7. Gomez, D.Y.; Wacher, V.J.; Tomlanovich, S.J.; Hebert, M.F. and Benet, L.Z. (1995) Clin. Pharmacol. Ther., 58, 15-19.
8. Gorski, J.C.; Jones, D.R.; Haehner-Daniels, B.D.; Hamman, M.A.; O'Mara, E.M., Jr. and Hall, S.D. (1998) Clin. Pharmacol. Ther., 64, 133-143.
9. Floren, L.C.; Bekersky, I.; Benet, L.Z.; Mekki, Q.; Dressler, D.; Lee, J.W.; Roberts, J.P. and Hebert, M.F. (1997) Clin. Pharmacol. Ther., 62, 41-49.
10. Galetin, A.; Burt, H.; Gibbons, L. and Houston, J.B (2006) Drug Metab. Dispos., 34, 166-175.
11. Rostami-Hodjegan, A. and Tucker, G.T. (2004) Drug Discov. Today: Technol., 1, 441-448.
12. Wang, Y-H.; Jones, D.R. and Hall, S.D (2004) Drug Metab. Dispos., 32, 259-266.
13. Obach, R.S.; Walsky, R.L.; Venkatakrishnan, K.; Gaman, E.A.; Houston, J.B. and Tremaine, L.M. (2006) J. Pharmacol. Exp. Ther., 316, 336-348.
14. Tucker, G.T.; Houston, J.B. and Huang, S-M (2001) Clin. Pharmacol. Ther., 70, 103-114.
15. Bjornsson, T.D.; Callaghan, J.T.; Einolf, H.J.; Fischer, V. et al. (2003) Drug. Metab. Dispos., 31, 815-832.
16. Ito, K.; Brown, H.S. and Houston, J.B. (2004) Br. J. Clin. Pharmacol., 57, 473-486 and Erratum, Br. J. Clin. Pharmacol., 58, 565-568.
17. Brown, H.S.; Ito, K.; Galetin, A. and Houston, J.B. (2005) Br. J. Clin. Pharmacol., 60, 508-158.
18. Galetin, A.; Ito, K.; Hallifax, D. and Houston, J.B. (2005) J. Pharmacol. Exp. Ther., 314, 180-190.
19. Ito, K.; Hallifax, D.; Obach, S. and Houston, J.B. (2005) Drug Metab. Dispos., 33, 837-844.
20. Chien, J.Y.; Lucksiri, A.; Ernest, I.I.C.S.; Gorski, C.; Wrighton, S.A. and Hall, S.D. (2006) Drug. Metab. Dispos, 34(7), 1208-1219.
21. Brown, H.S.; Galetin, A.; Hallifax, H. and Houston, J.B. (2006) Clin. Pharmacokinet., 45, 1035-1050.
22. Wu, C-Y. and Benet, L.Z. (2005) Pharm. Res., 22, 11-23.
23. Hall, S.D.; Thummel, K.E.; Watkins, P.B.; Lown, K.S.; Benet, L.Z.; Paine, M.F.; Mayo, R.R.; Turgeon, D.K.; Bailey, D.G.; Fontana, R.J. and Wrighton, S.A. (1999) Drug. Metab. Dispos., 27, 161-166.
24. Thummel, K.E.; Kunze, K.L.; Shen, D.D. (1997) Adv. Drug. Deliv. Rev., 27, 99-127.
25. Yang, J.; Tucker, G.T.; Rostami-Hodjegan, A. (2004) Clin. Pharmacol. Ther., 76, 391.
26. Backman, J.T.; Wang, J-S.; Wen, X.; Kivisto, K., T. and Neuvonen, P.J. (1999) Clin. Pharmacol. Ther., 66, 401-407.
27. Mayhew, B.S.; Jones, D.R. and Hall, S.D. (2000) Drug Metab. Dispos., 28, 1031-1037.
28. Prueksaritanont, T.; Ma, B.; Tang, C.; Meng, Y.; Assang, C.; Lu, P.; Reider, P.J.; Lin, J.H. and Baillie, T.A. (1999) Br. J. Clin. Pharmacol., 47, 291-298.
29. Greenblatt, D.J.; von, Moltke, L.L.; Harmatz, J.S.; Durol, A.L.B.; Daily, J.P.; Graf, J.A.; Mertzanis, P.; Hoffman, J.L. and Shader, R.I. (2000) Clin. Pharmacol. Ther., 67, 335-341.
30. Ernest, C.S.II.; Hall, S.D. and Jones, D.R. (2005) J. Pharm. Exp. Ther., 312, 583-591.
31. Palkama, V.J.; Ahonen, J.; Neuvonen, P.J. and Olkkola, K.T. (1999) Clin. Pharmacol. Ther., 66, 33-39.
32. Backman, J.T.; Olkkola, K.T.; Aranko, K.; Himberg, J.J. and Neuvonen, P.J. (1994) Br. J. Clin, Pharmacol., 37, 221-225.
33. Yeo, K.R. and Yeo, W.W. (2001) Br. J. Clin. Pharmacol., 51, 461-470.
34. Lasher, T.A.; Fleishaker, J.C.; Steenwyk,. R.C. and Antal, E.J. (1991) Psychopharmacology, 104, 323-327.
35. Lin, J.H.; Chiba, M. and Baillie, T.A. (1999) Phamacol. Rev., 51, 135-158
36. Lennemas, H. (2003) Clin. Pharmacokinet., 42(13) 1141-60.
37. Hebert, M.F.; Roberts, J.P.; Prueksaritanont, T. and Benet, L.Z. (1992) Clin. Pharmacol. Ther., 52, 453-457.
38. Ducharme, M.P.; Warbasse, L.H. and Edwards, D.J. (1995) Clin. Pharmacol. Ther., 57(5) 485-91.
39. Gupta, S.K.; Bakran, A.; Johnson, R.W. and Rowland, M. (1989) Br. J. Clin. Pharmacol., 27(4) 475-81.
40. Lundahl, J.; Regardh, C.G.; Edgar, B. and Johnsson, G. (1997) Eur. J. Clin. Pharmacol., 52, 139-145.
41. Lee, J.I.; Chaves-Gnecco, D.; Amico, J.A.; Kroboth, P.D.; Wilson, J.W. and Frye, R.F. (2002) Clin. Pharmacol. Ther., 72, 718-728.
42. Olkkola, K.T.; Aranko, K.; Luurila, H.; Hiller, A.; Saarnivaara, L.; Himberg, J.J. and Neuvonen, P.J. (1993) Clin. Pharmacol. Ther., 53, 298-305.
43. Masica, A.L.; Mayo, G. and Wilkinson, G.R. (2004) Clin. Pharmacol. Ther., 76, 341-349.
44. Thummel, K.E.; O'Shea, D.; Paine, M.F.; Shen, P.D.; Kunze, K.L.; Perkins, J.D. and Wilkinson, G.R. (1996) Clin. Pharmacol. Ther., 59, 491-502.
45. Tateishi, T.; Watanabe, M.; Nakura, H.; Asoh, M.; Shirai, H.; Mizorogi, Y.; Kobayashi, S.; Thummel, K.E. and Wilkinson, G.R. (2001) Clin. Pharmacol. Ther., 69, 333-439.
46. Wang, Z.; Gorski, J.C.; Hamman, M.A.; Huang, S.M.; Lesko, L.J. and Hall, S.D. (2001) Clin. Pharmacol. Ther., 70, 317-326.
47. Saari, T.I.; Laine, K.; Leino, K.; Valtonen, M.; Neuvonen, P.J. and Olkkola, K.T. (2006) Clin. Pharmacol. Ther., 79, 362-370.
48. Holtbecker, N.; Fromm, M.F.; Kroemer, H.K.; Ohnhaus, E.E. and Heidemann, H.H. (1996) Drug Metab. Dispos., 24, 1121-1123.
49. Damkier, P.; Hansen, L.L. and Brosen, K. (1999) Eur. J. Clin. Pharmacol., 55, 451-456.
50. Hirota, N.; Ito, K.; Iwatsubo, T.; Green, C.E.; Tyson, C.A.; Shimada, N.; Suzuki, H. and Sugiyama, Y. (2001) Biopharm. Drug Dispos., 22, 53-71.
51. Daneshmend, T.K.; Warnock, D.W.; Eric,. M.D.; Johnson, E.M.; Potten, M.R.; Richardson, M.D. and Williamson, P.J. (1984) Antimicrob. Agents Chemother., 25, 1-3.
52. Bachmann, K.A. and Lewis, J.D. (2005) Ann. Pharmacother., 39, 1064-1072.
53. Grime, K. and Riley, R.J. (2006) Curr. Drug Metab., 7, 251-264.
54. Cummins, C.L.; Jacobsen, W.; Christians, U. and Benet, L.Z. (2004) J. Pharmacol. Exp. Ther., 308, 143-155.
55. Benet, L.Z.; Cummins, C.L. and Wu, C.Y. (2004). Int. J. Pharmaceut., 277, 3-9.
56. Wu, C-Y.; Benet, L.Z.; Hebert, M.F.; Gupta, S.K.; Rowland, M.; Gomez, D.Y. and Wacher, V.J. (1995) Clin. Pharmacol. Ther., 58, 492-497.
57. Backman, J.T.; Olkkola, K.T. and Neuvonen, P.J. (1996) Clin. Pharmacol. Ther., 59, 7-13.
58. Fromm, M.F.; Busse, D.; Kroemer, H.K. and Eichelbaum, M. (1996) Hepatology, 24, 796-801.
59. Kato, M.; Chiba, K.; Hisaka, A.; Ishigami, M.; Kayama, M.; Mizuno, N.; Nagata, Y.; Takakuwa, S.; Tsukamoto, Y.; Ueda, K,; Kusubars, H.; Ito, K. and Sugiyama, Y. (2003) Drug Metab. Pharmacokinet., 18, 365-372.
60. Lau, Y.Y.; Okochi, H.; Huang, Y. and Benet, L.Z. (2006) J. Pharmacol. Exp. Ther., 316, 762-771.
61. Ho, R.H. and Kim, R.B. (2006) Clin. Pharmacol. Ther., 78, 260-277.