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Archives of Biochemistry and Biophysics

Volumn 410, Issue 1, 2003, Pages 16-24

Activation of cytochrome P450 2C9-mediated metabolism: Mechanistic evidence in support of kinetic observations

(5) Hutzler, J Matthew a,b Wienkers, Larry C b Wahlstrom, Jan L c Carlson, Timothy J c Tracy, Timothy S a

a WEST VIRGINIA UNIVERSITY (United States)

b PFIZER INC (United States)

c ARQULE INC (United States)

Author keywords

Activation; Atypical kinetics; Cytochrome P450 2C9; Dapsone; Flurbiprofen; Stoichiometry

Indexed keywords

CYTOCHROME P450 2C9; DAPSONE; FLURBIPROFEN; N HYDROXYDAPSONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; WATER;

ARTICLE; BINDING AFFINITY; HYDROXYLATION; KINETICS; MEASUREMENT; PRIORITY JOURNAL; PROTEIN METABOLISM; REDUCTION; REGULATORY MECHANISM; STOICHIOMETRY;

ARYL HYDROCARBON HYDROXYLASES; DAPSONE; FLURBIPROFEN; HUMANS; HYDROXYLATION; KINETICS; MECHANICS; METABOLIC DETOXICATION, DRUG; MODELS, BIOLOGICAL; NADP; OXYGEN;

EID: 0037325958 PISSN: 00039861 EISSN: None Source Type: Journal
DOI: 10.1016/S0003-9861(02)00665-3 Document Type: Article

Times cited : (73)

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