Hepatocellular binding of drugs: Correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

Drug Metabolism and Disposition

Volumn 36, Issue 7, 2008, Pages 1194-1197

  Kilford, Peter J ^a   Gertz, Michael ^a   Houston, J Brian ^a   Galetin, Aleksandra ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ALDOSTERONE; ALPHA NAPHTHOFLAVONE; ANDROSTENEDIONE; ASTEMIZOLE; BETAXOLOL; BUMETANIDE; CAFFEINE; CERIVASTATIN; CLOZAPINE; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; DRUG; ETHENZAMIDE; FLUCONAZOLE; FLUOXETINE; GEMFIBROZIL; GLIBENCLAMIDE; HYDROCORTISONE; IMIPRAMINE; INDAPAMIDE; ISRADIPINE; KETOCONAZOLE; METYRAPONE; MICONAZOLE; NALOXONE; OXAPROZIN; PRASTERONE; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG UPTAKE; HUMAN; HUMAN CELL; LIPOPHILICITY; LIVER CELL; LIVER MICROSOME; MATHEMATICAL MODEL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

HEPATOCYTES; LIPIDS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS;

EID: 46449126478     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.020834     Document Type: Article

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