Enzyme kinetics of cytochrome P450-mediated reactions

Current Drug Metabolism

Volumn 2, Issue 1, 2001, Pages 17-36

  Shou, Magang ^a   Lin, Yuh ^a   Lu, Ping ^a   Tang, Cuyue ^a   Mei, Qin ^a   Cui, Dan ^a   Tang, Wei ^a   Ngui, Jason S ^a   Lin, C Charles ^a   Singh, Rominder ^a   Wong, Bradley K ^a   Yergey, James A ^a   Lin, Jiunn H ^a   Pearson, Paul G ^a   Baillie, Thomas A ^a   Rodrigues, A David ^a   Rushmore, Thomas H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; BENZYLOXYRESORUFIN; CELECOXIB; CYTOCHROME P450; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; ETHOXYRESORUFIN; LOSARTAN; NORDAZEPAM; OXAZEPAM; PROGESTERONE; QUINIDINE; RESORUFIN DERIVATIVE; TEMAZEPAM; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG INTERACTION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; INHIBITION KINETICS; MICHAELIS MENTEN KINETICS; MODEL; PHARMACOKINETICS; TRANSPORT KINETICS;

ALGORITHMS; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; HUMANS; KINETICS;

EID: 0035004408     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200013338784     Document Type: Article

References (47)

1. "Drug interaction and updates."
2. The human hepatic cytochromes P450 involved in drug metabolism
3. Cytochrome P450: Structure, Mechanism, and Biochemistry
4. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research
5. Enzyme Kinetics: Behaviour and Analysis of Rapid Equilibrium and Steady State Enzyme Systems
6. Molecular modeling of mammalian cytochromes P450