Critical reviews in oral biology & medicine: Transcriptome remodeling in hypoxic inflammation

Journal of Dental Research

Volumn 89, Issue 5, 2010, Pages 430-444

  Safronova, O ^a   Morita, I ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

HDAC.; HIF; Hypoxia; Inflammation; NF B

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

CELL HYPOXIA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; INFLAMMATION; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

CELL HYPOXIA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INFLAMMATION; NF-KAPPA B; RECEPTOR CROSS-TALK; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 77951112875     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510366813     Document Type: Article

References (160)

1. Adcock IM, Ito K. (2005). Glucocorticoid pathways in chronic obstructive pulmonary disease therapy. Proc Am Thorac Soc 2: 313-319. (Pubitemid 41566942)
2. Adcock IM, Ito K., Barnes PJ (2004). Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc 1: 247-254.
3. Aguilera C., Hoya-Arias R., Haegeman G., Espinosa L., Bigas A. (2004). Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci USA 101: 16537-16542.
4. Albina JE, Mastrofrancesco B., Vessella JA, Louis CA, Henry WL Jr, Reichner JS (2001). HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol 281: C1971 - C1977.
5. Arany Z., Huang LE, Eckner R., Bhattacharya S., Jiang C., Goldberg MA, et al. (1996). An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93: 12969-12973.
6. Ashburner BP, Westerheide SD, Baldwin AS Jr (2001). The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21: 7065-7077.
7. Auphan N., DiDonato JA, Rosette C., Helmberg A., Karin M. (1995). Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286-290.
8. Backdahl L., Bushell A., Beck S. (2009). Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation Int J Biochem Cell Biol 41: 176-184.
9. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (2002). Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110: 55-67.
10. Barnes PJ, Karin M. (1997). Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071.
11. Basu M., Sawhney RC, Kumar S., Pal K., Prasad R., Selvamurthy W. (2002). Glucocorticoids as prophylaxis against acute mountain sickness. Clin Endocrinol (Oxf) 57: 761-767.
12. Belaiba RS, Bonello S., Zahringer C., Schmidt S., Hess J., Kietzmann T., et al. (2007). Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. Mol Biol Cell 18: 4691-4697.
13. Berger SL, Kouzarides T., Shiekhattar R., Shilatifard A. (2009). An operational definition of epigenetics. Genes Dev 23: 781-783.
14. Beyer S., Kristensen MM, Jensen KS, Johansen JV, Staller P. (2008). The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem 283: 36542-36552.
15. Bjornheden T., Levin M., Evaldsson M., Wiklund O. (1999). Evidence of hypoxic areas within the arterial wall in vivo. Arterioscler Thromb Vasc Biol 19: 870-876.
16. Blanchard F., Chipoy C. (2005). Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases ? Drug Discov Today 10: 197-204.
17. Bracken CP, Whitelaw ML, Peet DJ (2005). Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. J Biol Chem 280: 14240-14251.
18. Campbell KJ, Rocha S., Perkins ND (2004). Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13: 853-865.
19. Castro R., Rivera I., Struys EA, Jansen EE, Ravasco P., Camilo ME, et al. (2003). Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem 49: 1292-1296.
20. Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. (2000). Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275: 25130-25138.
21. Charo IF, Ransohoff RM (2006). The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354: 610-621.
22. Chelbi ST, Mondon F., Jammes H., Buffat C., Mignot TM, Tost J., et al. (2007). Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia. Hypertension 49: 76-83.
23. Chen H., Yan Y., Davidson TL, Shinkai Y., Costa M. (2006). Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 66: 9009-9016.
24. Chen LF, Greene WC (2004). Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 5: 392-401.
25. Chen X., El Gazzar M., Yoza BK, McCall CE (2009). The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem 284: 27857-27865.
26. Chen ZJ, Parent L., Maniatis T. (1996). Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862.
27. Chung YL, Lee MY, Wang AJ, Yao LF (2003). A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. Mol Ther 8: 707-717.
28. Clayton AL, Hazzalin CA, Mahadevan LC (2006). Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell 23: 289-296.
29. Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, et al. (2006). Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci USA 103: 14767-14772.
30. Coussens LM, Werb Z. (2002). Inflammation and cancer. Nature 420: 860-867.
31. Cramer T., Yamanishi Y., Clausen BE, Forster I., Pawlinski R., Mackman N., et al. (2003). HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112: 645-657.
32. Cummins EP, Taylor CT (2005). Hypoxia-responsive transcription factors. Pfl1/4gers Arch 450: 363-371.
33. Cummins EP, Berra E., Comerford KM, Ginouves A., Fitzgerald KT, Seeballuck F., et al. (2006). Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci USA 103: 18154-18159.
34. Dardzinski BJ, Smith SL, Towfighi J., Williams GD, Vannucci RC, Smith MB (2000). Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment. Pediatr Res 48: 248-255.
35. De Bosscher K., Vanden Berghe W., Haegeman G. (2006). Cross-talk between nuclear receptors and nuclear factor kappaB. Oncogene 25: 6868-6886.
36. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S., van Kuilenburg AB (2003). Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370 (Pt 3). 737-749.
37. Dehne N., Brune B. (2009). HIF-1 in the inflammatory microenvironment. Exp Cell Res 315: 1791-1797.
38. Denko N., Wernke-Dollries K., Johnson AB, Hammond E., Chiang CM, Barton MC (2003). Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem 278: 5744-5749.
39. Dewhirst MW, Cao Y., Moeller B. (2008). Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437 ; erratum in Nat Rev Cancer 8: 654, 2008.
40. Edwards RA, Witherspoon M., Wang K., Afrasiabi K., Pham T., Birnbaumer L., et al. (2009). Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res 69: 6423-6429.
41. El Gazzar M., Yoza BK, Chen X., Hu J., Hawkins GA, McCall CE (2008). G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem 283: 32198-32208.
42. El Gazzar M., Yoza BK, Chen X., Garcia BA, Young NL, McCall CE (2009). Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol 29: 1959-1971.
43. Ellis L., Hammers H., Pili R. (2009). Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 280: 145-153.
44. Endres M., Meisel A., Biniszkiewicz D., Namura S., Prass K., Ruscher K., et al. (2000). DNA methyltransferase contributes to delayed ischemic brain injury. J Neurosci 20: 3175-3181.
45. Feinberg AP, Tycko B. (2004). The history of cancer epigenetics. Nat Rev Cancer 4: 143-153.
46. Feinberg AP, Vogelstein B. (1983). Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89-92. Finegold SM (1987). Anaerobic bacteria. Their role in infection and their management. Postgrad Med 81: 141-147.
47. Fischer S., Renz D., Schaper W., Karliczek GF (2001). In vitro effects of dexamethasone on hypoxia-induced hyperpermeability and expression of vascular endothelial growth factor. Eur J Pharmacol 411: 231-243.
48. Fischler M., Maggiorini M., Dorschner L., Debrunner J., Bernheim A., Kiencke S., et al. (2009). Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. Am J Respir Crit Care Med 180: 346-352.
49. Flaus A., Owen-Hughes T. (2004). Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer? Curr Opin Genet Dev 14: 165-173.
50. Frede S., Stockmann C., Freitag P., Fandrey J. (2006). Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J 396: 517-527.
51. Fuks F., Burgers WA, Godin N., Kasai M., Kouzarides T. (2001). Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 20: 2536-2544.
52. Gerritsen ME, Williams AJ, Neish AS, Moore S., Shi Y., Collins T. (1997). CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci USA 94: 2927-2932.
53. Glanemann M., Strenziok R., Kuntze R., Munchow S., Dikopoulos N., Lippek F., et al. (2004). Ischemic preconditioning and methylprednisolone both equally reduce hepatic ischemia/reperfusion injury. Surgery 135: 203-214.
54. Granger A., Abdullah I., Huebner F., Stout A., Wang T., Huebner T., et al. (2008). Histone deacetylase inhibition reduces myocardial ischemiareperfusion injury in mice. FASEB J 22: 3549-3560.
55. Guney S., Schuler A., Ott A., Hoschele S., Zugel S., Baloglu E., et al. (2007). Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+K+-ATPase and epithelial Na+ channels. Am J Physiol Lung Cell Mol Physiol 293: L1332 - L1338.
56. Hanukoglu A., Fried D., Nakash I., Hanukoglu I. (1995). Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants. Eur J Endocrinol 133: 552-556.
57. Heck S., Bender K., Kullmann M., Gottlicher M., Herrlich P., Cato AC (1997). I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J 16: 4698-4707.
58. Herman JG, Latif F., Weng Y., Lerman MI, Zbar B., Liu S., et al. (1994). Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91: 9700-9704. (Pubitemid 24311875)
59. Hoberg JE, Yeung F., Mayo MW (2004). SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell 16: 245-255.
60. Hoberg JE, Popko AE, Ramsey CS, Mayo MW (2006). IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/ p65 by p300. Mol Cell Biol 26: 457-471.
61. Hodge DR, Xiao W., Clausen PA, Heidecker G., Szyf M., Farrar WL (2001). Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J Biol Chem 276: 39508-35911.
62. Hu CJ, Chen SD, Yang DI, Lin TN, Chen CM, Huang TH, et al. (2006). Promoter region methylation and reduced expression of thrombospondin-1 after oxygen-glucose deprivation in murine cerebral endothelial cells. J Cereb Blood Flow Metab 26: 1519-1526.
63. Huang Y., Zhao JJ, Lv YY, Ding PS, Liu RY (2009). Hypoxia down-regulates glucocorticoid receptor alpha and attenuates the anti-inflammatory actions of dexamethasone in human alveolar epithelial A549 cells Life Sci 85: 107-112.
64. Imbert V., Rupec RA, Livolsi A., Pahl HL, Traenckner EB, Mueller-Dieckmann C., et al. (1996). Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86: 787-798.
65. Israel A. (2000). The IKK complex: an integrator of all signals that activate NF-kappaB ? Trends Cell Biol 10: 129-133.
66. Ito K., Barnes PJ, Adcock IM (2000). Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 20: 6891-6903.
67. Jaenisch R., Bird A. (2003). Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl): 245-254.
68. Jepsen K., Rosenfeld MG (2002). Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci 115 (Pt 4). 689-698.
69. Johnson AB, Barton MC (2007). Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res 618: 149-162.
70. Johnson AB, Denko N., Barton MC (2008). Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res 640: 174-179.
71. Jung YJ, Isaacs JS, Lee S., Trepel J., Neckers L. (2003). IL-1beta-mediated upregulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 17: 2115-2117.
72. Jurrus ER, Weiss HS (1977). In vitro tissue oxygen tensions in the rabbit aortic arch. Atherosclerosis 28: 223-232.
73. Kang GH, Lee HJ, Hwang KS, Lee S., Kim JH, Kim JS (2003). Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol 163: 1551-1556.
74. Kato H., Tamamizu-Kato S., Shibasaki F. (2004). Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem 279: 41966-41974.
75. Kenneth NS, Rocha S. (2008). Regulation of gene expression by hypoxia. Biochem J 414: 19-29.
76. Kenneth NS, Mudie S., van Uden P., Rocha S. (2009). SWI/SNF regulates the cellular response to hypoxia. J Biol Chem 284: 4123-4131.
77. Kim HY, Kim YH, Nam BH, Kong HJ, Kim HH, Kim YJ, et al. (2007). HIF-1alpha expression in response to lipopolysaccaride [sic] mediates induction of hepatic inflammatory cytokine TNFalpha. Exp Cell Res 313: 1866-1876.
78. Kim MS, Kwon HJ, Lee YM, Baek JH, Jang JE, Lee SW, et al. (2001). Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 7: 437-443.
79. Kim SH, Jeong JW, Park JA, Lee JW, Seo JH, Jung BK, et al. (2007). Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep 17: 647-651.
80. Kim YH, Chung IY, Choi MY, Kim YS, Lee JH, Park CH, et al. (2007). Triamcinolone suppresses retinal vascular pathology via a potent interruption of proinflammatory signal-regulated activation of VEGF during a relative hypoxia. Neurobiol Dis 26: 569-576.
81. Kodama T., Shimizu N., Yoshikawa N., Makino Y., Ouchida R., Okamoto K., et al. (2003). Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression. J Biol Chem 278: 33384-33391.
82. Kong Y., Tannous P., Lu G., Berenji K., Rothermel BA, Olson EN, et al. (2006). Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation 113: 2579-2588.
83. Koong AC, Chen EY, Giaccia AJ (1994). Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 54: 1425-1430.
84. Kouzarides T. (2007). Chromatin modifications and their function. Cell 128: 693-705.
85. Kwon HJ, Kim MS, Kim MJ, Nakajima H., Kim KW (2002). Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int J Cancer 97: 290-296.
86. Lando D., Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471.
87. Lee SH, Kim J., Kim WH, Lee YM (2009). Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene 28: 184-194.
88. Leonard MO, Cottell DC, Godson C., Brady HR, Taylor CT (2003). The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem 278: 40296-40304.
89. Leonard MO, Godson C., Brady HR, Taylor CT (2005). Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor. J Immunol 174: 2250-2257.
90. Leoni F., Zaliani A., Bertolini G., Porro G., Pagani P., Pozzi P., et al. (2002). The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci USA 99: 2995-3000.
91. Leoni F., Fossati G., Lewis EC, Lee JK, Porro G., Pagani P., et al. (2005). The histone deacetylase inhibitor ITF2357 reduces production of proinflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med 11: 1-15.
92. Lewis JS, Lee JA, Underwood JC, Harris AL, Lewis CE (1999). Macrophage responses to hypoxia: relevance to disease mechanisms. J Leukoc Biol 66: 889-900.
93. Li B., Carey M., Workman JL (2007). The role of chromatin during transcription. Cell 128: 707-719.
94. Li Q., Ahuja N., Burger PC, Issa JP (1999). Methylation and silencing of the Thrombospondin-1 promoter in human cancer. Oncogene 18: 3284-3289.
95. Li Y., Yuan Z., Liu B., Sailhamer EA, Shults C., Velmahos GC, et al. (2008). Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition. J Trauma 64: 863-870.
96. Liu RS, Chu LS, Yen SH, Chang CP, Chou KL, Wu LC, et al. (1996). Detection of anaerobic odontogenic infections by fluorine-18 fluoromisonidazole. Eur J Nucl Med 23: 1384-1387.
97. Lund-Olesen K. (1970). Oxygen tension in synovial fluids. Arthritis Rheum 13: 769-776.
98. Maltepe E., Krampitz GW, Okazaki KM, Red-Horse K., Mak W., Simon MC, et al. (2005). Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 132: 3393-3403.
99. Manalo DJ, Rowan A., Lavoie T., Natarajan L., Kelly BD, Ye SQ, et al. (2005). Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669.
100. Marx J. (2004). Cancer research. Inflammation and cancer: the link grows stronger. Science 306: 966-968.
101. McCall CE, Yoza BK (2007). Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med 175: 763-767.
102. Mie Lee Y., Kim SH, Kim HS, Jin Son M., Nakajima H., Jeong Kwon H., et al. (2003). Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity. Biochem Biophys Res Commun 300: 241-246.
103. Minucci S., Pelicci PG (2006). Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6: 38-51.
104. Miyazaki Y., Hara A., Kato K., Oyama T., Yamada Y., Mori H., et al. (2008). The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma. Int J Oncol 32: 145-151.
105. Motoyama S., Saito S., Minamiya Y., Saito R., Nakamura M., Okuyama M., et al. (2003). Methylprednisolone inhibits low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused rat liver. Crit Care Med 31: 1468-1474.
106. Murdoch C., Muthana M., Lewis CE (2005). Hypoxia regulates macrophage functions in inflammation. J Immunol 175: 6257-6263.
107. Nathan C. (2002). Points of control in inflammation. Nature 420: 846-852. Neeck G., Renkawitz R., Eggert M. (2002). Molecular aspects of glucocorticoid hormone action in rheumatoid arthritis. Cytokines Cell Mol Ther 7: 61-69.
108. Nizet V., Johnson RS (2009). Interdependence of hypoxic and innate immune responses Nat Rev Immunol 9: 609-617.
109. Oda S., Oda T., Nishi K., Takabuchi S., Wakamatsu T., Tanaka T., et al. (2008). Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS One 3 (5). e2215.
110. Pal A., Srivastava T., Sharma MK, Mehndiratta M., Das P., Sinha S., et al. (2009). Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia. J Cell Mol Med [Epub ahead of print] June 5, 2009 (in press).
111. Perkins ND, Gilmore TD (2006). Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ 13: 759-772.
112. Pluemsampant S., Safronova OS, Nakahama K., Morita I. (2008). Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. Int J Cancer 122: 333-341.
113. Pollard PJ, Loenarz C., Mole DR, McDonough MA, Gleadle JM, Schofield CJ, et al. (2008). Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J 416: 387-394.
114. Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P., et al. (2006). Class II histone deacetylases are associated with VHLindependent regulation of hypoxia-inducible factor 1 alpha. Cancer Res 66: 8814-8821.
115. Reichardt HM, Tuckermann JP, Gottlicher M., Vujic M., Weih F., Angel P., et al. (2001). Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J 20: 7168-7173.
116. Rius J., Guma M., Schachtrup C., Akassoglou K., Zinkernagel AS, Nizet V., et al. (2008). NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453: 807-811.
117. Rodriguez PG, Felix FN, Woodley DT, Shim EK (2008). The role of oxygen in wound healing: a review of the literature. Dermatol Surg 34: 1159-1169.
118. Roh JL, Cho KJ, Kwon GY, Ryu CH, Chang HW, Choi SH, et al. (2009). The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol 45: 63-68.
119. Saccani S., Pantano S., Natoli G. (2001). Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med 193: 1351-1359.
120. Saccani S., Pantano S., Natoli G. (2002). p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3: 69-75.
121. Safronova O., Pluemsampant S., Nakahama K., Morita I. (2009). Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-kappaB and histone deacetylase. Int J Biochem Cell Biol 41: 2270-2280.
122. Schofield CJ, Ratcliffe PJ (2004). Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5: 343-354.
123. Scortegagna M., Cataisson C., Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, et al. (2008). HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood 111: 3343-3354.
124. Seagroves TN, Ryan HE, Lu H., Wouters BG, Knapp M., Thibault P., et al. (2001). Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 21: 3436-3444.
125. Semenza GL, Wang GL (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454.
126. Sengupta N., Seto E. (2004). Regulation of histone deacetylase activities. J Cell Biochem 93: 57-67.
127. Seo HW, Kim EJ, Na H., Lee MO (2009). Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett 583: 55-60.
128. Shahrzad S., Bertrand K., Minhas K., Coomber BL (2007). Induction of DNA hypomethylation by tumor hypoxia. Epigenetics 2: 119-125.
129. Shaw J., Zhang T., Rzeszutek M., Yurkova N., Baetz D., Davie JR, et al. (2006). Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes. Circ Res 99: 1347-1354.
130. Shetty S., Graham BA, Brown JG, Hu X., Vegh-Yarema N., Harding G., et al. (2005). Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol 25: 5404-5416.
131. Siddiqui A., Galiano RD, Connors D., Gruskin E., Wu L., Mustoe TA (1996). Differential effects of oxygen on human dermal fibroblasts: acute versus chronic hypoxia. Wound Repair Regen 4: 211-218.
132. Sposato B., Mariotta S., Palmiero G., Ricci A., Gencarelli G., Franco C. (2007). Oral corticosteroids can improve nocturnal isolated hypoxemia in stable COPD patients with diurnal PaO2 > 60 mmHg. Eur Rev Med Pharmacol Sci 11: 365-372.
133. Stenvinkel P., Karimi M., Johansson S., Axelsson J., Suliman M., Lindholm B., et al. (2007). Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease ? J Intern Med 261: 488-499.
134. Sullivan KE, Reddy AB, Dietzmann K., Suriano AR, Kocieda VP, Stewart M., et al. (2007). Epigenetic regulation of tumor necrosis factor alpha. Mol Cell Biol 27: 5147-5160.
135. Taylor CT (2008). Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation. J Physiol 586 (Pt 17). 4055-4099.
136. Taylor CT, Colgan SP (1999). Therapeutic targets for hypoxia-elicited pathways. Pharm Res 16: 1498-1505.
137. Teferedegne B., Green MR, Guo Z., Boss JM (2006). Mechanism of action of a distal NF-kappaB-dependent enhancer. Mol Cell Biol 26: 5759-5770.
138. Tilakaratne WM, Iqbal Z., Teh MT, Ariyawardana A., Pitiyage G., Cruchley A., et al. (2008). Upregulation of HIF-1alpha in malignant transformation of oral submucous fibrosis. J Oral Pathol Med 37: 372-377.
139. Tokudome S., Sano M., Shinmura K., Matsuhashi T., Morizane S., Moriyama H., et al. (2009). Glucocorticoid protects rodent hearts from ischemia/ reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J Clin Invest 119: 1477-1488.
140. Treuhaft PS, McCarty DJ (1971). Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum 14: 475-484.
141. Trousson A., Grenier J., Fonte C., Massaad-Massade L., Schumacher M., Massaad C. (2007). Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions. J Steroid Biochem Mol Biol 104: 305-311.
142. Valinluck V., Sowers LC (2007 a). Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67: 946-950.
143. Valinluck V., Sowers LC (2007 b). Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. Cancer Res 67: 5583-5586.
144. van Uden P., Kenneth NS, Rocha S. (2008). Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 412: 477-484.
145. Vanderbilt JN, Miesfeld R., Maler BA, Yamamoto KR (1987). Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol Endocrinol 1: 68-74.
146. Vaupel P., Thews O., Kelleher DK, Hoeckel M. (1998). Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology. Adv Exp Med Biol 454: 591-602.
147. Wagner AE, Huck G., Stiehl DP, Jelkmann W., Hellwig-Burgel T. (2008). Dexamethasone impairs hypoxia-inducible factor-1 function. Biochem Biophys Res Commun 372: 336-340.
148. Walmsley SR, Print C., Farahi N., Peyssonnaux C., Johnson RS, Cramer T., et al. (2005). Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 201: 105-115.
149. Wang F., Zhang R., Beischlag TV, Muchardt C., Yaniv M., Hankinson O. (2004). Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem 279: 46733-46741.
150. Watson JA, Watson CJ, McCrohan AM, Woodfine K., Tosetto M., McDaid J., et al. (2009). Generation of an epigenetic signature by chronic hypoxia in prostate cells. Hum Mol Genet 18: 3594-3604.
151. Wright A., Brearey S., Imray C. (2008). High hopes at high altitudes: pharmacotherapy for acute mountain sickness and high-altitude cerebral and pulmonary oedema. Expert Opin Pharmacother 9: 119-127.
152. Xenaki G., Ontikatze T., Rajendran R., Stratford IJ, Dive C., Krstic-Demonacos M., et al. (2008). PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene 27: 5785-5796.
153. Xia X., Lemieux ME, Li W., Carroll JS, Brown M., Liu XS, et al. (2009). Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA 106: 4260-4265.
154. Yang QC, Zeng BF, Shi ZM, Dong Y., Jiang ZM, Huang J., et al. (2006). Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. J Exp Clin Cancer Res 25: 593-599.
155. Yano A., Fujii Y., Iwai A., Kageyama Y., Kihara K. (2006). Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. Clin Cancer Res 12: 3003-3009. (Pubitemid 43837344)
156. Yeung F., Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, et al. (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380.
157. Yildirim F., Gertz K., Kronenberg G., Harms C., Fink KB, Meisel A., et al. (2008). Inhibition of histone deacetylation protects wildtype but not gelsolindeficient mice from ischemic brain injury. Exp Neurol 210: 531-542.
158. Zakrzewska A., Schnell PO, Striet JB, Hui A., Robbins JR, Petrovic M., et al. (2005). Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells. J Neurochem 94: 1288-1296.
159. Zhang W., Petrovic JM, Callaghan D., Jones A., Cui H., Howlett C., et al. (2006). Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol 174: 63-73.
160. Zhong H., May MJ, Jimi E., Ghosh S. (2002). The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9: 625-636.