Site-specific phosphorylation of IκBα by a novel ubiquitination- dependent protein kinase activity

Cell

Volumn 84, Issue 6, 1996, Pages 853-862

  Chen, Z J ^a   Parent, L ^a   Maniatis, T ^a  

^a Mass Inc Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; UBIQUITIN;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; STRESS;

EID: 0030004897     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81064-8     Document Type: Article

References (48)

1. I Alkalay A Yaron A Hatzubai S Jung A Avraham O Gerlitz I Pashut-Lavon Y Ben-Neriah In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB Mol. Cell. Biol. 15 1995 1294 1301
2. I Alkalay A Yaron A Hatzubai A Orian A Ciechanover Y Ben-Neriah Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway Proc. Natl. Acad. Sci. USA 92 1995 10599 10603
3. T Arnason M.J Ellison Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain Mol. Cell. Biol. 14 1994 7876 7883
4. C.F Barroga J.K Stevenson E.M Schwarz I.M Verma Constitutive phosphorylation of IκBα by casein kinase II Proc. Natl. Acad. Sci. USA 92 1995 7637 7641
5. M.P Belvin Y Jin K.V Anderson Cactus protein degradation mediates Drosophila dorsal-ventral signaling Genes Dev. 9 1995 783 793
6. J.A Brockman D.C Scherer S.M Hall T.A McKinsey X Qi W.Y Lee D.W Ballard Coupling of a signal-response domain in IκBα to multiple pathways for NF-κB activation Mol. Cell. Biol. 15 1995 2809 2818
7. K Brown S Gerstberger L Carlson G Franzoso U Siebenlist Control of IκB-α proteolysis by site-specific, signal- induced phosphorylation Science 267 1995 1485 1491
8. V Chau J.W Tobias A Bachmair D Marriott D.J Ecker D.K Gonda A Varshavsky A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein Science 243 1989 1576 1583
9. P Chen P Johnson T Sommer S Jentsch M Hochstrasser Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor Cell 74 1993 357 369
10. Z.J Chen J Hagler V.J Palombella F Melandri D Scherer D Ballard T Maniatis Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway Genes Dev. 9 1995 1586 1597
11. A Ciechanover The ubiquitin–proteasome proteolytic pathway Cell 79 1994 13 21
12. J.A DiDonato F Mercurio M Karin Phosphorylation of IκB precedes but is not sufficient for its dissociation from NF-κB Mol. Cell. Biol. 15 1995 1302 1311
13. T.S Finco A.S Baldwin Jr. Mechanistic aspects of NF-κB regulation the emerging role of phosphorylation and proteolysis Immunity 3 1995 263 272
14. T.S Finco A.A Beg A.S Baldwin Jr. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors Proc. Natl. Acad. Sci. USA 91 1994 11884 11888
15. S Ghosh D Baltimore Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB Nature 344 1990 678 682
16. A.L Goldberg Functions of the proteasome the lysis at the end of the tunnel Science 268 1995 522 523
17. A.L Haas P.M Bright The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates J. Biol. Chem. 250 1985 12464 12473
18. A.L Haas P.M Bright The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes J. Biol. Chem. 263 1988 13258 13267
19. S Haskill A.A Beg S.N Tompkins J.S Morris A.D Yurochko A Sampson-Johannes K Mondal P Ralph A.S Baldwin Jr. Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activities Cell 65 1991 1281 1289
20. A Hershko H Heller Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates Biochem. Biophys. Res. Commun. 128 1985 1079 1086
21. A Hershko H Heller E Eytan Y Reiss The protein substrate binding site of the ubiquitin-protein ligase system J. Biol. Chem. 261 1986 11992 11999
22. J.M Huibregtse M Scheffner S Beaudenon P Howley A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase Proc. Natl. Acad. Sci. USA 92 1995 2563 2567
23. R.W King J.-M Peters S Tugendreich M Rolfe P Hieter M.W Kirschner A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B Cell 81 1995 279 288
24. A Kumar J Haque J Lacoste J Hiscott B Williams Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB Proc. Natl. Acad. Sci. USA 91 1994 6288 6292
25. K Kuno Y Ishikawa M.K Ernst M Ogata N.R Rice N Mukaida K Matsushima Identification of an IκBα-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on IκBα J. Biol. Chem. 270 1995 27914 27919
26. W.-C Lin S Desiderio Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation Science 260 1993 953 959
27. Y.-C Lin K Brown U Siebenlist Activation of NF-κB requires proteolysis of the inhibitor IκB-α signal-induced phosphorylation of IκB-α alone does not release active NF-κB Proc. Natl. Acad. Sci. USA 92 1995 552 556
28. S.D Menon S Qin G.R Guy Y.H Tan Differential induction of nuclear NF-κB by protein phosphatase inhibitors in primary and transformed human cells J. Biol. Chem. 268 1993 26805 26812
29. S Miyamoto M Maki M.J Schmitt M Hatanaka I.M Verma Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB Proc. Natl. Acad. Sci. USA 91 1994 12740 12744
30. 2 in Mos EMBO J. 12 1993 4021 4027
31. A Orian S Whiteside A Israel I Stancovski A.L Schwartz A Ciechanover Ubiquitin-mediated processing of NF-κB transcriptional activator precursor p105 J. Biol. Chem. 270 1995 21707 21714
32. M Pagano S.W Tam A.M Theodoras P Beer-Romero G Del Sal V Chau P Renee Yew G.F Draetta M Rolfe Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 Science 269 1995 682 685
33. V.J Palombella O.J Rando A.L Goldberg T Maniatis The ubiquitin–proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB Cell 78 1994 773 785
34. C.M Pickart I.A Rose Functional heterogeneity of ubiquitin carrier proteins J. Biol. Chem. 260 1985 1573 1581
35. M Scheffner J.M Huibregtse R.D Vierstra P.M Howley The HPV-16 E6 and E6-AP complex functions as a ubiquitin–protein ligase in the ubiquitination of p53 Cell 75 1993 495 505
36. D.C Scherer J.A Brockman Z.J Chen T Maniatis D Ballard Signal-induced degradation of IκBα requires site-specific ubiquitination Proc. Natl. Acad. Sci. USA 92 1995 11259 11263
37. R Schreck P Rieber P.A Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1 EMBO J. 10 1991 2247 2258
38. SIC1 controls the G1 to S transition in S. cerevisiae Cell 79 1994 233 244
39. W Seufert S Jentsch Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins EMBO J. 9 1990 543 550
40. U Siebenlist G Franzoso K Brown Structure, regulation and function of NF-κB Annu. Rev. Cell Biol. 10 1994 405 455
41. J Spence S Sadis A.L Haas D Finley A ubiquitin mutant with specific defects in DNA repair and multiubiquitination Mol. Cell. Biol. 15 1995 1265 1273
42. V Sudakin D Ganoth A Dahan H Heller J Hershko F.C Luca J.V Ruderman A Hershko The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis Mol. Biol. Cell 6 1995 185 198
43. D Thanos T Maniatis NF-κB a lesson in family values Cell 80 1995 529 532
44. E.B.-M Traenckner S Wilk P.A Baeuerle A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB EMBO J. 13 1994 5433 5441
45. E.B.-M Traenckner H.L Pahl T Henkel K.N Schmidt S Wilk P.A Baeuerle Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli EMBO J. 14 1995 2876 2883
46. I.M Verma J.K Stevenson E.M Schwarz D Van Antwerp S Miyamoto Rel/NF-κB/IκB family intimate tales of association and dissociation Genes Dev. 9 1995 2723 2735
47. S.T Whiteside M.K Ernst O LeBail C Laurent-Winter N Rice A Israel N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-κB activity Mol. Cell. Biol. 15 1995 5339 5345
48. cdc28-mediated control of Cln3 cyclin degradation Mol. Cell. Biol. 15 1995 731 741