Checkpoint signaling: Epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase

BioEssays

Volumn 25, Issue 7, 2003, Pages 627-630

  Abraham, Robert T ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; MONOMER;

ARTICLE; CELL FUNCTION; CHROMATIN STRUCTURE; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENOME; HUMAN; IONIZING RADIATION; PROTEIN DOMAIN; PROTEIN FUNCTION; RADIATION EXPOSURE; SIGNAL TRANSDUCTION;

CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; LEUCINE ZIPPERS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 0037829284     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10310     Document Type: Article

References (16)

1. Bakkenist CJ, Kastan MB DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421:499-506.
2. Zhou BBS, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-439.
3. Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996;274:1664-1672.
4. Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 2003;3:155-168.
5. Tibbetts RS, Abraham RT. PI3K-related kinases - Roles in cell-cycle regulation and DNA damage responses: signaling networks and cell cycle control: the molecular basis of cancer and other diseases. 2000; 5:267-301.
6. Shiloh Y. ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev 2001;11:71-77.
7. Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 1995;83:1-4.
8. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001;15:2177-2196.
9. Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev 1997;11:3471-3481.
10. Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-1677.
11. Ruiz de Almodovar JM, Bush C, Peacock JH, Steel GG, Whitaker SJ, McMillan TJ. Dose-rate effect for DNA damage induced by ionizing radiation in human tumor cells. Radiation Res 1994;138:S93-S96.
12. Cedervall B, Wong R, Albright N, Dynlacht J, Lambin P, Dewey WC. Methods for the quantification of DNA double-strand breaks determined from the distribution of DNA fragment sizes measured by pulsed-field gel electrophoresis. Radiation Res 1995;143:8-16.
13. Erixon K, Cedervall B. Linear induction of DNA double-strand breakage with X-ray dose, as determined from DNA fragment size distribution. Radiation Res 1995;142:153-162.
14. Koziov S, Gueven N, Keating K, Ramsay J, Lavin MF. ATP activates ataxia-telangiectasia mutated (ATM) in vitro - Importance of autophosphorylation. J Biol Chem 2003;278:9309-9317.
15. Cunliffe VT. Memory by modification: the influence of chromatin structure on gene expression during vertebrate development. Gene 2003;305: 141-150.
16. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genetics 2002;3:415-428.