Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status

Current Medicinal Chemistry

Volumn 17, Issue 10, 2010, Pages 929-956

  Rodrigues, T ^a   Lopes, F ^a   Moreira, R ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

bc1 complex; Dihydroorotate dehydrogenase; Electron transport chain; Malaria; Mitochondria; Succinate dehydrogenase; Type II NADH dehydrogenase

Indexed keywords

AABLAQUINE; ACRIDONE DERIVATIVE; ANTIMALARIAL AGENT; ATOVAQUONE; AURACHIN A; AURACHIN B; AURACHIN C; AURACHIN D; BREQUINAR; CHALCONE DERIVATIVE; DIHYDROOROTATE DEHYDROGENASE; FUNICULOSIN; GW 308678; GW 844520; LEFLUNOMIDE; MYXOTHIAZOL; NAPHTHOQUINONE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIDONE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STIGMATELLIN A; STIGMATELLIN B; SUCCINATE DEHYDROGENASE; TAFENOQUINE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; MAMMAL; METABOLIC INHIBITION; MULTIDRUG RESISTANCE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; RESPIRATORY CHAIN; REVIEW; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANTIMALARIALS; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; MITOCHONDRIA; NADH DEHYDROGENASE; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PYRIMIDINES; SUCCINATE DEHYDROGENASE;

EID: 77950637685     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790820660     Document Type: Review

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