Malarial dihydroorotate dehydrogenase: Substrate and inhibitor specificity

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 41827-41834

  Baldwin, Jeffrey ^a,b,c   Farajallah, Azizeh M ^b   Malmquist, Nicholas A ^b   Rathod, Pradipsinh K ^b   Phillips, Margaret A ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CELLS; DISEASES; DRUG PRODUCTS; GENETIC ENGINEERING; MICROORGANISMS; OXIDATION; PH EFFECTS;

CATALYTIC EFFICIENCY;

ENZYMES;

DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTIC ACID DERIVATIVE; FLAVINE MONONUCLEOTIDE; ISOPRENOID; LAWSONE; MENADIONE; OROTIC ACID; PYRIMIDINE; TERIFLUNOMIDE; UBIQUINONE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; IC 50; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PLASMODIUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; SEQUENCE ALIGNMENT; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANILINE COMPOUNDS; ANIMALS; BINDING SITES; BIPHENYL COMPOUNDS; CATALYSIS; CLONING, MOLECULAR; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYBUTYRATES; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; SUBSTRATE SPECIFICITY; UBIQUINONE;

ESCHERICHIA COLI; MAMMALIA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036830528     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206854200     Document Type: Article

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