Molecular Basis for Atovaquone Resistance in Pneumocystis jirovecii Modeled in the Cytochrome bc1 Complex of Saccharomyces cerevisiae

Journal of Biological Chemistry

Volumn 279, Issue 4, 2004, Pages 2817-2824

  Kessl, Jacques J ^a   Hill, Philip ^b   Lange, Benjamin B ^a   Meshnick, Steven R ^c   Meunier, Brigitte ^b   Trumpower, Bernard L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ANALYSIS; ENZYMES; MALARIA CONTROL; MICROORGANISMS; MOLECULAR STRUCTURE; MUTAGENS; OXIDATION; SUBSTITUTION REACTIONS; YEAST;

CYTOCHROMES;

BIOCHEMISTRY;

ATOVAQUONE; NAPHTHOQUINONE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CYTOCHROME B GENE; GENE; GENE MUTATION; MALARIA; MITOCHONDRIAL MEMBRANE; NONHUMAN; PLASMODIUM FALCIPARUM; PNEUMOCYSTIS; PNEUMONIA; PRIORITY JOURNAL; PROPHYLAXIS; PROTOZOAL INFECTION; PSEUDOMONAS JIROVECII; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; TARGET ORGAN;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; ATOVAQUONE; BINDING SITES; DRUG RESISTANCE, FUNGAL; ELECTRON TRANSPORT COMPLEX III; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NAPHTHOQUINONES; PNEUMOCYSTIS JIROVECI; PROTEIN BINDING; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE;

NEGIBACTERIA; PLASMODIUM FALCIPARUM; PNEUMOCYSTIS; PNEUMOCYSTIS JIROVECII; PSEUDOMONAS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 1642535428     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309984200     Document Type: Article

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