Modeling the Qo site of crop pathogens in Saccharomyces cerevisiae cytochrome b

European Journal of Biochemistry

Volumn 271, Issue 11, 2004, Pages 2264-2271

  Fisher, Nicholas ^a   Brown, Amanda C ^a   Sexton, Graham ^b   Cook, Alison ^b   Wimdass, John ^b   Meunier, Brigitte ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

bc1 complex; Cytochrome b; Inhibitors; Plant pathogens; Qo; Resistance

Indexed keywords

CYTOCHROME B; MYXOTHIAZOL; ANTIFUNGAL AGENT; HYDROQUINONE DERIVATIVE; UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; GENETIC RESISTANCE; MOLECULAR DYNAMICS; NONHUMAN; OOMYCETES; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; CROP; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MUTATION; PATHOGENICITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

BLUMERIA GRAMINIS; ERYSIPHE; OOMYCETES; PHYTOPHTHORA; PHYTOPHTHORA MEGASPERMA; PODOSPHAERA FULIGINEA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; VENTURIA INAEQUALIS;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; BINDING SITES; CELL DIVISION; CROPS, AGRICULTURAL; CYTOCHROMES B; DRUG RESISTANCE, FUNGAL; ELECTRON TRANSPORT COMPLEX III; HYDROQUINONES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 2942511339     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04169.x     Document Type: Article

References (13)

1. Gisi, U., Sierotzki, H., Cook, A. & McCaffery, A. (2002) Mechanisms influencing the evolution of resistance to Qo inhibitor fungicides. Pest Manag. Sci. 58, 859-867.
2. P inhibitors. Eur. J. Biochem. 235, 54-63.
3. Hill, P., Kessl, J.J., Meshnick, S.R., Trumpower, B.L. & Meunier. B. (2003) Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci. Antimicrob. Agents Chemother. 47, 2725-2731.
4. Vanneste, W.H. (1966) Molecular proportion of the fixed cytochrome components of the respiratory chain of Keilin-Hartree particles and beef heart mitochondria. Biochim. Biophys. Acta 113, 175-178.
5. Cornish-Bowden, A. (1995) Fundamentals of Enzyme Kinetics. Portland Press, London.
6. 1. Nature 392, 677-684.
7. Kazanjian, P., Armstrong, W., Hossler, P.A., Huang, L., Beard, C.B., Carter, J., Crane, L., Duchin, J., Burman, W., Richardson, J. & Meshnick, S.R. (2001) Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. J. Infect. Dis. 183, 819-822.
8. 1 complex. J. Biol. Chem. 278, 31312-31318.
9. Howell, N. & Gilbert, K. (1988) Mutational analysis of the mouse mitochondrial cytochrome b gene. J. Mol. Biol. 203, 607-618.
10. Chin, K.M., Chavaillaz, D., Kaesbohrer, M., Staub, T. & Felsenstein, F.G. (2001) Characterizing resistance risk of Erysiphe graminis f.sp. tritici to strobilurins. Crop Protection 20, 87-96.
11. 1 enzyme comples of Mycosphaerella fijiensis field isolates. Pest Manag. Sci. 56, 833-841.
12. 1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure Fold. Des. 8, 669-684.
13. Humphrey, W., Dalke, A. & Schulten, K. (1996) VMD - visual molecular dynamics. J. Mol. Graph. 14, 33-38.