Quinolones and their N-oxides as inhibitors of mitochondrial complexes I and III

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1318, Issue 1-2, 1997, Pages 291-298

  Reil, Ellen ^a   Höfle, Gerhard ^b   Draber, Wilfried ^c   Oettmeier, Walter ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c NONE   (Germany)

Author keywords

Beef heart; Cytochrome bc1 complex; NADH:Ubiquinone oxidoreductase; Oxidant induced reduction; Q(p) site inhibitor; Rhodospirillum rubrum; Structure activity relationship

Indexed keywords

QUINOLONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HEART MITOCHONDRION; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RHODOSPIRILLUM RUBRUM; SUBMITOCHONDRIAL PARTICLE;

ANIMALS; BINDING SITES; CATTLE; CYTOCHROME B GROUP; CYTOCHROMES C1; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; KINETICS; MITOCHONDRIA; MITOCHONDRIA, HEART; NAD(P)H DEHYDROGENASE (QUINONE); QUINOLONES; RHODOSPIRILLUM RUBRUM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; BOS TAURUS; RHODOSPIRILLUM RUBRUM;

EID: 0343907259     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2728(96)00150-8     Document Type: Article

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