Current status of malaria control

Current Medicinal Chemistry

Volumn 12, Issue 22, 2005, Pages 2643-2659

  Tripathi, R P ^a   Mishra, R C ^a   Dwivedi, N ^a   Tewari, N ^a   Verma, S S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimalarial agents; Artemesinines; Chloroquine; Combination chemotherapy; Drug resistance; Pentamidines; Peroxides; Quinines; Vaccines

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; ATOVAQUONE; AZITHROMYCIN; CHLOROQUINE; CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; FOLIC ACID; FOSMIDOMYCIN; GLYCEROPHOSPHOLIPID; GLYCOSYLPHOSPHATIDYLINOSITOL; HALOFANTRINE; HEME; MALARIA VACCINE; MEFLOQUINE; MEPACRINE; OXIDOREDUCTASE INHIBITOR; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; PROGUANIL; PROTEINASE; QUININE; QUINOLONE DERIVATIVE; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; TETANUS TOXOID; THIOLACTOMYCIN; TRICLOSAN; UNINDEXED DRUG;

ABDOMINAL PAIN; ACUTE DISEASE; ANTIMALARIAL ACTIVITY; APICOPLAST; BIOCHEMISTRY; BRAIN DISEASE; CELL METABOLISM; CHEMOTHERAPY; CLINICAL TRIAL; DIARRHEA; DRUG CONJUGATION; DRUG COST; DRUG EFFICACY; DRUG ERUPTION; DRUG HALF LIFE; DRUG INDUSTRY; DRUG RESEARCH; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTRON TRANSPORT; ENZYME METABOLISM; ERYTHROCYTE; GLYCOLYSIS; HOST PARASITE INTERACTION; HUMAN; IMMUNOTHERAPY; LIFE CYCLE; LIPID METABOLISM; MALARIA; MALARIA CONTROL; MEDICAL LITERATURE; MENTAL DISEASE; MITOCHONDRION; MOLECULAR LIBRARY; MORTALITY; MOSQUITO; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PARASITE VECTOR; PARASITOSIS; PATHOGENESIS; PLASMODIUM; PRURITUS; REVIEW; VACCINATION; VALIDATION PROCESS;

ANIMALS; ANTIMALARIALS; GENOMICS; HUMANS; IMMUNOTHERAPY; MALARIA; PHOSPHATIDYLINOSITOLS; PLASMODIUM MALARIAE;

EID: 26844528909     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986705774370673     Document Type: Review

References (180)

1. Looareesu Walsh J.A. Ann N.Y. Acad Sci 1989, 569, 1-16.
2. (a) Sachs, J.; Malaney, P. Nature 2002, 415, 680-685.
3. (b) Greenwood, B.; Mutabingwa, T. Nature 2002, 415, 670-672 and references cited therein
4. Ridley, R. G. Nature 2002, 415, 686-693.
5. Wirth, D. F. Nature 2002, 419, 495-496.
6. R. Ross. Studies on Malaria, John Murray Publishers, London, 1928.
7. Oaks, S. C.; Mitchell, V. S.; Pearson, G. W.; Carpenter, C. C. J. eds.; Malaria: obstacles and opportunities Washington: National Academy Press; 1991.
8. Foye, W. O. In Principles of Medicinal Chemistry; Foye, W. O., Lemke, T. L., Williams, D. A., eds.; Williams & Wilkins: Philadelphia, 1995, ch. 32.
9. Balter, M.; Marshall, E.; Vogel, G.; Taubes, G.; Pennisi, E.; Enserink, M. Science 2000, 290, 428-441.
10. Lopez-Antinano, F. J.; Schmunis, G. A. Academic: New York, 1993, 5, 146-169.
11. Daviss, B. Malaria, Science and Social Responsibilies The Scientist 2005, 19(6), 42
12. Oaks, S. C., Mitchel, V. S., Pearson, G. W., Carpenter, C. C. J., Eds.; National Academy: Washington, DC, 1991.
13. Raynes, K. Int J. Parasitol. 1999, 29, 367-79 and references cited therein.
14. Snow, R. W.; Omombo, J. A.; Lowe. B.; Molyneux, C. S.; Obiero. J. O.; Palmer. A.; Heber. M. H.; Pinder, M.; Nahlem. B.; Obonyo, C.; Newbold, C.; Gupta. S.; Marsk, K. Lancet 1997, 349, 1650-1654.
15. Warrell, D. A.; Molyneux., M. E.; Beales. P. F. Trans. R. Soc. Trop. Med. Hyg. 1990, 84, 1-65.
16. Wernsdorfer, W. H.; and Mc Gregor, I. Malaria: Principles and Practice of Malariology London: Churchill Livingstone, 1988.
17. Bone, R. C. Crit. Care Med. 1996, 24, 163-172.
18. Beeson, J. G.; Brown, G. V. Cell Mol. Life Sci. 2002, 59, 258-271.
19. Mons, B. Parasitology 1985, 91, 423-430,
20. Dondorp, A. M.; Nyanoti, M.; Kager, P. A.; Mithwani, S.; Vreeken, J.; Marsh, K. Trans. R. Soc. Trop. Med. Hyg. 2002, 96, 282-286.
21. Kroeger. A.; Manecheno. M.; Alareno, J.; Pesse, K. Am. J. Trop. Med. Hyg. 1995, 53, 313-323.
22. Lyimo, E. O.; Msuya, F. H. M.; Rwegoshora, R. T.; Nicholson, E. A.; Mnzava, A. E. P.; Lines, J. D.; Curtis, C. F. Acta Trop. 1991, 49, 157-163
23. Alonso, P L.; Lindsay. S. W.; Armstrong. J. R. M.; Conteh, M.; Hill, A. G.; David, P. H.; Fegan. G.; Francisco, A. D.; Hall, A. J.; Shenton, F. C.; Cham, K.; Greenwood, B. M. Lancet, 1991, 337, 1499-1502
24. Mitchel, C. J. Environmental management for vector control In The Biology of disease Vectors. Eds. Beaty and W.C. Marquardt. University of Colorado, Colorado, p. 492, 1996.
25. Vector control for malaria and mosquito home diseases, report of a WHO study group, WHO Geneva, 1995.
26. Mitchel, C. J. Environmental management for vector control in: The biology of disease vectors Edts B.J. Beaty and Marquardt W.C. University of Colorado, Colorado, 492, 1996.
27. Mendis, K. N.; Sina, B. J.; Marchesini, P.; Carter, R. Am. J. Trop. Med. Hyg. 2001, 64, 97-106.
28. Hisaeda, H.; Stowers, A. W.; Tsuboi, T.; Collins, W. E.; Sattabongkot, J. S.; Suwanabun, N.; Torii, M.; Kaslow, D. C. Infect. Immun. 2000, 68, 6618-6623.
29. Offman, S. L. ASM Press, 1996, Malaria Vaccine Development: A Multi-immune Response Approach. Washington, DC
30. Migasena, S.; Heppner, D. G.; Kyle, D. E.; Chongsuphajaisiddhi, T.; Gordon, D. M.; Suntharasamai, P.; Permpanich, B.; Brockman, A.; Pitiuttutham, P.; Wongsrichanalai; C.; Srisuriya, P.; Phonrat, B.; Pavanand, K.; Viravan, C.; Ballou, W. R. Acta Trop. 1997, 67, 215-27.
31. (a) Graves, P.; Gelband, H. Rev. Cochrane Database Syst. Rev. 2003, (1):CD000129.
32. (b) al-Yaman, F.; Genton, B.; Taraika, J.; Anders, R.; Alpers, M. P. Parasit. Immunol. 1997, 19, 207-14.
33. Tine, J. A.; Lanar, D. E.; Smith, D. M.; Wellde, B. T.; Schultheiss, P.; Ware, L. A.; Kaufman, E. B.; Wirtz, R. A.; De Taisne, C.; Hui, G. S.; Chang, S. P.; Church, P.; Hollingdale, M. R.; Kaslow, D. C.; Hoffman, S.; Guito, K. P.; Ballou, W. R.; Sadoff, J. C.; Paoletti, E. Infect. Immun. 1996, 64, 3833-44.
34. (a) Bojang, K. A.; Milligan, P. J.; Pinder, M.; Vigneron, L.; Alloueche, A.; Kester, K. E.; Ballou, W. R.; Conway, D. J.; Reece, W. H.; Gothard, P.; Yamuah, L.; Delchambre, M.; Voss, G.; Greenwood, B. M.; Hill, A.; McAdam, K. P.; Tornieporth, N.; Cohen, J. D.; Doherty, T. Lancet, 2001, 358. 1927-1934.
35. (b) Alonso, P. L.; Sacarlal, J.; Aponte, J. J.; Leach, A.; Macete, E.; Milman, J.; Mandomando, I.; Spiessens, B.; Guinovart, C.; Espasa, M.; Bassat, Q.; Aide, P.; Ofori-Anyinam, O.; Navia, M. M.; Corachan, S.; Ceuppens, M.; Dubois, M. C.; Demoitie, M. A.; Dubovsky, F.; Menendez, C.; Tornieporth, N.; Ballou, W. R.; Thompson, R.; Cohen, J. Lancet. 2004, 16, 364, 1380-3.
36. Williamson, K. C. Parasite Immunol 2003, 25, 351-359 and references cited therein)
37. (a) Tuteja, R. Crit. Rev. Biochem. Mol. Biol. 2002, 37, 29-54.
38. (b) Hedstrom, R. C.; Doolan, D. L.; Wang, R.; Gardner, M. J.; Kumar, A.; Sedegah, M.; Gramzinski, R. A.; Sacci, J. B. Jr.; Charoenvit, Y.; Weiss, W. R.; Margalith, M.; Norman, J. A.; Hobart, P.; Hoffman, S. L. Springer Semin Immunopathol. 1997, 19, 147-59.
39. (a) Cohen, S.; McGregor, I. A.; Carrington, S. Nature 1961, 192, 733-737
40. (b) Goldring, J. P. Immunonol. Cell Biol. 2004, 82(4), 447-452
41. (a) Hoffman, I. F.; Jere, C. S.; Taylor, T. E.; Munthali, P.; Dyer, J. R.; Hassan-King, M.; Frodisham, A.; Bennet, S.; Hill, A. V. S.; Whittle, H. Nature 1997, 352, 595-600.
42. (b) McConkey, S. J.; Reece, W. H.; Moorthy, V. S.; Webster, D.; Dunachie, S.; Butcher, G.; Vuola, J. M.; Blanchard, T. J.; Gothard, P.; Watkins, K. Nat. Med. 2003. 9, 729-735.
43. Sabchareon, A.; Burnouf, T.; Ouattara, D.; Attanath, P.; Bouharoun- Tayoun, H.; Chantavanich, P.; Foucault, C.; Chongsuphajaisiddhi, T.; Druilhe, P. Am. J. Trop. Med. Hyg. 1991, 45, 297-308.
44. Cohen, S.; McGregor, I. A.; Carrington, S. Nature 1961, 192, 733-737.
45. (a) Schofield, L.; Vivas, L.; Hackett, F.; Gerold, P.; Schwarz, R. T.; Tachado, S. Ann. Trop. Med. Parasitol 1993, 87, 617-626.
46. (b) Altman, J. D.; Moss, Goulder, P. A.; Barouch, P. J.; McHeyzer-Williams, D. H.; Bell, M. G.; McMichael, J. I.; Davis, M. M. Science 1996, 274, 94-96.
47. Herr, W.; Schneider, J.; Lohse, A. W.; Meyer zum Buschenfelde, K. H.; Wolfel, T. J. Immunol. Methods 1996, 191, 131-142.
48. Murali-Krishna, K.; Altman, J. D.; Suresh, M.; Sourdive, D. J.; Zajac, A. J.; Miller, J. D.; Slansky, J.; Ahmed, R. Immunity 1998, 8, 177-187.
49. De Jager, W.; Te Velthuis, H.; Prakken, B. J.; Kuis, W.; Rijkers, G. T. Clin. Diagnost. Lab. Immunol. 2003, 10, 133-139.
50. The Lancet editorial, Malaria after the genomes The Lancet 2002, 360, 1107.
51. Horrocks, P.; Bowman, S.; Kyes, S.; Waters, A.; Craig, A. Bull. World Health Organisation. 2000, 78, 1424-1437.
52. Buysse, J. Curr. Med. Chem. 2001, 8, 1763-1776.
53. Gardner, M. J.; Hall, N.; Fung, E.; White, O.; Berriman, M.; Hyman, R. W.; Carlton, J. M.; Pain, A.; Nelson, K. E.; Bowman, S.; Paulsen, I. T.; James, K.; Eisen, J. A.; Rutherford, K.; Salzberg, S. L.; Craig A.; Kyes, S.; Chan, M. S.; Nene, V.; Shallom, S. J.; Suh, B.; Peterson, J.; Angiuoli, S.; Pertea, M.; Allen, J.; Selengut, J.; Haft, D.; Mather, M. W.; Vaidya, A. B.; Martin, D. M.; Fairlamb, A. H.; Fraunholz, M. J.; Roos, D. S.; Ralph, S. A.; McFadden, G. I.; Cummings, L. M.; Subramanian, G. M.; Mungall, C.; Venter, J. C.; Carucci, D. J.; Hoffman, S. L.; Newbold, C.; Davis, R. W.; Fraser, C. M.; Barrell, B. Nature 2002, 419, 498-511.
54. Banniste, R. L.; Parasitol. Today 2000, 16, 427-433.
55. Fry, M.; Beesley, J. Parasitol. Today 1999, 102, 17-26.
56. Krungkrai, J.; Krungkrai S. R.; Suraveratum, N.; Prapunwattana, P. Biochem. Mol. Biol. Int. 1997, 42, 007-14.
57. Vaidya, A. in Antimalarial Chemotherapy, Mechanism of action, Resistance and new directions in Drug Discovery (ed. Rosenthal P.) Totawa, N J, Humana Press 2001, pp. 203-218.
58. Alzeer. I.; Collet. J.; Hemze., K.; Hebschwerbn, C.; Matile, H.; Ridley, R. G. J. Med. Chem. 2000, 43, 560-568.
59. (a) Woodrow, C. J.; Penny, J. I.; Krishna, S. J. Biol. Chem. 1999, 274, 7272-7277 and refrences cited therein
60. (b) Fry, M.; Webb, E.; Pudney, M., Comp. Biochem. Physiolo B, 1990, 96, 775-782
61. Roth, E.; Rosa, R. Blood 1988, 71, 1408-1413 and references cited therein
62. Brady. R. L. Current Drugs 2004, 5, 137-149.
63. Vander, J. D. L.; Hansdkn. L. A.; Heidrech, J. E.; Mol. Biochem. Parasitol. 1981, 4, 255-264.
64. Rastelli, G.; Sirawaraporn, W.; Sompornpisut, P.; Vilaivan, K. S.; Quarrel, R.; Lowe, G.; Thebtaranonth, Y.; Yuthavong, Y. Bioorg. Med. Chem. 2000, 8, 1117.
65. Clough, B.; Wilson, R. J. M. Antibiotics and the plasmodial plastic organelle. In Antimalarial Chemotherapy (ed. P. J. Rosenthal), Totawa, T.; Humana, N. J. Press otawa, N J, Humana Press. 2001, pp. 287-312.
66. Canfield, C. J.; Pudney, M.; Gutteridge, W. E. Exp. Parasitol. 1995, 80, 505-516
67. Francis, S.; Sullivam, D. J.; Goldberg, D. Annu. Rev. Microbiol. 1997, 51, 97-123.
68. Combs, G. H.; Golberg, D. E.; Klemba, M.; Berry. C.; Kay, J.; Mottram, J. C. Trends in Parasitol. 2001, 17, 532-537.
69. Shenai, B.; Sijwali, P.; Singh, A.; Rosenthal, P. J. Biol. Chem. 2000, 275, 29000-29010.
70. Eggelson, K.; Duttin, K.; Gloldberg, D. J. Biol. Chem. 1999, 274, 32411-32417
71. McKerrow, J. H.; Sun, E.; Rosenthal, P. J.; Bouvier, J. Annu Rev Microbiol 1993. 47, 821-53.
72. Noteberg, D.; Hamelink, E.; Hulten, J.; Wahlgren, M.; Vrang, L.; Samuelsson, B.; Hallberg, A. J Med Chem. 2003, 46, 734-46.
73. Silva, A. M.; Lee, A. Y.; Gulnik, S. V.; Maier, P.; Collins, H.; Bhat, T. N.; Collins, P. J.; Cachau, R. E.; Luker, K. E.; Gluzman, I. Y.; Francis, S. E.; Oksman, A.; Goldberg, D. E.; Erickson, J. W. Proc. Natl. Acad. Sci. USA. 1996, 93, 10034-9.
74. Rosenthal, P. J.; Meshnick, S. R. Mol. Biochem. Parasitol. 1996, 83, 131-9.
75. Slater, A. F. G. Exp. Parasitol. 1992, 74, 362-5.
76. Bond, J. S.; Butler, P. E. Annu. Rev. Biochem. 1987, 56, 333-64.
77. Gluzman, I. Y.; Francis, S. E.; Oksman, A.; Smith, C. E.; Duffin, K. L.; Goldberg D. E. J. Clin. Invest. 1994, 93, 1602-8.
78. Chow, A.; Cherti, R.; Fitch, C. Biochemistry, 1980, 19, 1543-1549.
79. Sullivan, D. J.; Gluzerman, I.; Russel, D.; Goldberg, D. Proc. Natl. Acad. Sciences 1996, 93, 11865-11870.
80. Bray, P.; Mungthin, M.; Ridley, R.; Ward, S. Mol. Pharmacol. 1998, 54, 170-179.
81. Mungthin, M.; Bray, P.; Ridley, R.; Ward, S. Antimicrob. Agents. Chemother. 1998, 42, 2973-2977.
82. Sullivan, D. J.; Matile, H.; Ridlley, R.; Goldberg, D. A J. Biol. Chem. 1998, 273, 31103-31107.
83. Meshnik, S.; Talor, T.; Komchonwongpaison, S. Microbiol. Rev. 1996, 60, 301-315.
84. Meshnik, S. in Antimalarial chemotherapy, Mechanism of Action, Resistance and new directions in drug discovery (ed. Rosenthal P) 191-202 (Humana, Totowa, New Jersy, 2001).
85. Foth, B. J.; Ralph, S. A.; Tonkin, C. J.; Struck, N. S.; Fraunholz, M.; Roos, D. S.; Cowman, A. F.; McFadden, G. I. Science 2003 299, 705-708.
86. Ralph, S. A.; D'Ombrain, M. C.; McFadden, G. I. Drug Resist. Update 2001, 4, 145-151.
87. Roos, D. S.; Crawford, M. J.; Donald, R. G.; Fraunholz, M.; Harb, O. S.; He, C. Y.; Kissinger, J. C.; Shaw, M. K.; Striepen, B. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2002, 357, 35-46.
88. Jones, S. M.; Urch, J. E.; Brun, R.; Harwood, J. L.; Berry, C.; Gilbert, I. H. Bioorganic Med Chem. 2004, 12, 683-692 and references cited therein.
89. Surolia, N.; Surolia, A. Nature Med. 2001, 7, 167-173.
90. Jornna, H.; Wiesner, J.; Sandarbrand, S.; Altincicek, B.; Weidemeyer, C.; Hintz, N.; Turvaehova, I.; Eberal, M.; Zeidler, J.; Lichtenthaler, H. K.; Soldati, D.; Beck., E. Science 1999, 285, 1573-1576.
91. Wiesner, J.; Borrmann, S.; Jomaa, H. Parasitol Res. 2003, June: 90 Suppl. 2:S71-76.
92. Gerold, P.; Dieckmann-Schuppert, A.; Schwarz, R. T. J Biol. Chem. 1994, 269, 2597-2606.
93. Gowda, D. C.; Gupta, P.; Davidson, E. A. J. Biol. Chem. 1997, 272, 6428-6439.
94. Eckert, V.; Gerold, P.; Schwarz, R. T.; GPI-anchors: structure and functions, in: H. J. Gabius, S. Gabius (Eds.), Glycosciences,, Chapman & Hall, Weinheim,, Germany, 1997, pp. 223-243.
95. Schofield, L.; Tachado, S. D. Immunol. Cell Biol. 1996, 74, 555-563.
96. Gerold, P.; Jung, N.; Azzouz, N.; Frieberg, N.; Kobe, S.; Schwarz, R. T. Biochem. J. 1999, 344, 731-738 and references cited therein.
97. Vial, H. J.; Thuet M. J.; Broussal, J. L.; Philippot, J. R. J. Parasitol 1982, 68, 379-391.
98. Hsiao, L. L.; Howard, R. J.; Aikawa, M.; Taraschi, T. F. Biochem. J. 1991, 274 121-132.
99. Mitamura, T.; Palacpac, N. M. Q. Microbes and Infection 2003, 5, 545-552.
100. Matesanz, F.; Duran-Chica, I; Alcina, A. J. Mol. Biol. 1999, 291, 59-70.
101. Meinnel, T. Biochimie 1993, 75, 1061-75
102. Meinnel, T. Parasioloy Today 2001, 16(4), 165-68.
103. Rogers, M. J.; Cundliffe, E.; Mc Cutehan, T. F. Antimicrob. Agents. Chemother. 1998, 42, 715-716.
104. Meinnel, T.; Patiny, N.; Ragusa, S.; Blanquet, S. Biochemistry 1999, 38, 4287-4295.
105. (a) Hynes, J. B.; Hack, L. G. J Med Chem. 1972, 15, 194-6.
106. (b) Mishra, R. C.; Tripathi, Renu; Katiyar, D.; Tewari, N.; Singh, D.; and Tripathi, R. P. Bioorg. Med. Chem., 2003, 11, 5363-5374.
107. Scheibel, L. W.; Adler, A.; Trager, W. Proc. Natl. Acad. Sci. USA 1979, 76, 5303-5307
108. Becker, K.; Rahlfs, S.; Nickel, C.; Schirmer, R. H.; Biol. Chem. 2003, 348, 551-566.
109. Rainer, M. L.; James, H. M.; Kenneth, T. D.; Micheal J. D.; Janet, V. J. Enzyme inhibition 1998, 13, 327-345.
110. White, J. J. N.; Engl J Med, 1996, 335, 800-806.
111. Luzzi, G. A.; Peto, T. E. A. Drug Safety, 1993, 8, 295-311.
112. (a) Keystone, J. S.; Drugs, 1990, 39, 337-354.
113. (b) Meinnel, T. Parasitology Today, 2000, 16, 165-68.
114. Ridley, R. C. Nature 2002, 415, 686-693.
115. Report no WHO/CDS/RBM/2001.33 (World Health Organization, Geneva 2001.)
116. Report no WHO/CDS/RBM/2001.35 (World Health Organization, Geneva 2001.
117. Report no WHO/MAL/98.1086 (World Health Organization, Geneva 1998.)
118. Winstanley, P. Lancet, 1996, 348, 1196-1201.
119. Skinner-Adams, T.; Davis, T. M. E. Antimicrob. Agents Chemother 1999, 43, 1304-1306.
120. Panisko, D. M.; Keystone, J. S. Drugs 1990, 39, 160-189.
121. Price, E. J.; Bevan, J. S.; Rees, A.; Br. J. Clin. Pract. 1992, 36, 138-139
122. Gottschall, J. L.; Elliot, W.; Lianos, E.; Farland, J. G. M.; Biolfmeyer, K.; Aster, R. H. Blood 1991, 77, 306-310.113.
123. Glynne, P. Am. J. Kidney Dis. 1999, 33, 1333-1337.
124. Dollery, C. ed. Chloroquin, in therapeutic drugs (2nd edition) pp. C177-C182, Churchil Livingston, 1999.
125. Wernsdorfer, W. H. Parasitol. Today, 1991, 7, 297-303 and references cited therein.
126. Bruce-Chwatt, L. J.; Black; R. H.; Canfield, C. J.; Clyde, D. F.; Peters, W.; Wernsdorfer, W. H.; (Eds.) Chemotherapy of Malaria 2nd edition, WHO; Geneva 1986.
127. Dollery, C. Eds. Chloroquin, in therapeutic drugs (2nd edition 1999) Mefloquin pp M24-M30, Churchil Livingston.
128. Winstanley, P. A. Br. J. Clin. Pharmacol. 1996, 42, 411-414.
129. Dollery, C., ed. Chloroquin, in therapeutic drugs (2nd edition 1999) Halofrantin, H1-H2 Churchil Livingston.
130. Milton, K.; Edward, G.; Hard, S. A.; orme, M.L.; Breckenridge., A. M.; Br. J. Clin. Pharmacol. 1989, 27, 671-672.
131. Monlun, E.; Leenhardt, A.; Pillet, O.; Gaston, R.; Receveur, M. C.; Bouabdallah, K.; Longy-Boursier, M.; Favarel-Garrigues, J. C.; Le Bras, M.; Bull. Soc. Path. Exot. 1993, 86, 365-368.
132. Puri, S. K.; Singh, N. Exp Parasitol. 2000, 94, 8-14.
133. Winstanley, P. A. Parasitol. Today 2000, 16, 146-153
134. De Vries, P. J.; Dien, T. K. Drugs 1996, 52, 818-36.
135. (a)Tan, Y.; Dong, Y.; Vennestrom, J. L.; Med. Res. Rev. 2004, 24, 425-448 and references cited therein.
136. (b) Bostnik, K., Paik, I. H.; Sapairo, T.A.; Posner, G. H. Int. J. Parasitol. 2002, 32, 1661-1667.
137. (c) Dong, Y. Mini. Rev. Med. Chem. 2002, 2, 113-1123.
138. (d) Vroman, J. A.; Alvin-Gaston, M.; Avery, M. A. Curr. Pharm. Des. 1999, 5, 101-138.
139. (e) Jefford, C. W. Adv. Drug Res. 1997, 29, 271-325.
140. (f) Jefoord, C. W. Curr. Med. Chem. 2001, 8, 1803-1826.
141. Teja-Isavadharm, P.; James O. P.; Thomas G. B.; Nicholas J. W.; Webster H. K.; Dennis E. K. Antimicrob Agents Chemother. 2004, 48, 954-960.
142. Van Hensbroek, M. B.; Tran T. H.; Nicholas, P. J.; Day. Nguyen Hoen Nguyen Thi Hoang Mai.; Tran Thi H. C.; Dinhxuan, S.; Ly Van, C.; Ha vinh, Deborah, W.; Timonthy. E. A.; Peto, D.; Phil, B. M.; Nicholas. J. W. New. Engl. J. Med. 1996, 335, 76-83.
143. Hieh, T. New Engl. J. Med. 1996, 335, 76-83.
144. Murphy, S.; English. M,; Waruiru, C. X; Mwangi, I.; Amukoye. E.; Crawley, J.; Newton, C.; Winstanley, P.; Peshu, N.; Marsk. K. Trans. R. Soc. Trop. Med. Hyg. 1996, 90, 298-301.
145. Pittler, M. H.; Ernst, E. Clin. Infect. Dis. 1999, 28, 597-601.
146. Murphy, S. A.; Mberu, E.; Mahia, D.; English. M.; Crawley. J.; Waruiru, C.; Lowe. B.; Newton. C. R. J.; HInstanley, P.; Marsh, K.; Watkins. W. M. Trans. R. Soc. Trop. Med. Hyg. 1997, 91, 331-334.
147. Foote, S. J.; Cowman, A. F. Acta Trop. 1994, 56, 157-171
148. Peters, W. 1987, Chemotherapy and drug resistance in malaria, 2nd ed. Academic Press, London, United Kingdom.
149. Pudney, M. Soc. Gen. Microbiol. 1994, 53, 229-247.
150. Bunnag, D.; Viravan, C.; Looareesuwan, S. Karbwang, J.; Harinasuta, T. Southeast Asian J. Trop. Med. Public Health 1991, 22, 380-385.
151. Murphy, G. S.; Basri, H.; Purnomo, A. E. M.; Bangs, M. J.; Mount, D. L.; Gorden, J.; Lal, A. A.; Purwokusumo, A. R.; Harjosuwarno, S. Lancet 1993, 341, 96-100.
152. Price, R. N.; Nosten, F.; Luxemburger, C.; van Vugt, M.; Phaipun, L.; Chongsuphajaisiddhi, T.; White, N. J. Trans. R. Soc. Trop. Med. Hyg. 1997, 91, 574-577.
153. White, N. J. J. Antimicrob. Chemother. 1992, 30, S71-S78
154. Schuurkamp, G. J.; Spicer, P. E.; Keren, R. K.; Bulungol, P. K.; Rieckmann, K. H. Trans. R. Soc. Trop. Med. Hyg. 1992, 86, 121-122
155. Bloland, P. B.; Kazembe, P. N.; Watkins, W. M.; Doumbo, O. K.; Nwanyanwu, O. C.; Ruebush, T. K. Lancet, 1997, 350, 1624-1625 and references cited therein
156. Winstanley, P.; Watkins, W, Muhia, D.; Szwandt, S.; Amukoye, E.; Marsh, K. Trans. R. Soc. Trop. Med. Hyg. 1997, 91, 322-327
157. (a) Salako, L. A.; Adio, R. A.; Sowunmi, A.; Walker, O. Trans. Royal Soc. Trop. Med. Hyg. 1990, 84, 641-643.
158. (b) Hellgren, U.; Kihamia, C. M.; Bergqvist, Y.; Lebbad, M.; Premji, Z.; Rombo, L. Trans. R. Soc. Trop. Med. Hyg. 1990, 84, 469-73
159. Toovey, A.; Nettleton, G. Travel Med. Infect. Dis. 2003, 1, 177-179.
160. Kuemmerle, H. P.; Murakawa, T.; Soneoka, K.; Konishi, T. Int. J. Clin. Pharmacol. Ther. Toxicol. 1995, 23, 515-520.
161. Clyde, D. F.; Gilman, R.; McCarthy, H. Am. J. Trop. Med. Hyg. 1975, 24, 3659-370.
162. Lell, B.; Kremsner, P. G. Antimicrob. Agents and Chemother. 2002, 476, 2315-20 and references cited therein.
163. Bagley, A.; Bashford, M. C.; Hesketh, K. E.; Moody, C. J. J. Am. Chem. Soc., 2000, 122, 3301-3313.
164. Moody, C. J.; Bagley, M. C. J. Chem. Soc., Perkin Trans. 1 1998, 601-607.
165. Chawanee, S.; Chakapong, I.; Sumalee, K.; Jarunee, V.; Yodhathai, T.; Yongyuth, Y. J. Med. Chem. 2004, 47(2), 345-354.
166. Timothy, J.; Egan, K.; Koch, R.; Paul, L.; Swan, C. C.; Donlley, A.; Van Schalkwyk; Smith, P. J. S. J. Med. Chem. 2004, 47, 2926-2934.
167. Annie, M.; Jean, J.; Vanden, E.; Fran, M.; Krogstad, Donald, J.; Krogstad, Melanie, T.; Cushion, Tien L. H. J. Med Chem. 47, 2004, 2700-2705.
168. (a) Colin, W.; Wright, J. A. K.; Anthony, G. B.; Brown, J. E.; Cox, M. F.; Croft S. L.; Gökçek, Y.; Kendrick, H.; Phillips, R. M.; Pollet, Pamela, L. J. Med. Chem, 2001, 44(19), 3187-3194.
169. (b) Jonckers, T. H. M.; Miert, van S. K. C.; Bailly, C.; Colson, P. G.; Claire De, P. M.; van den, H. H.; Claeys, M.; Lemière, F.; Esmans, E. L.; Rozenski, J.; Quirijnen, L.; Maes, L.; Dommisse, R.; Lemière, Guy L. F.; Vlietinck, A.; Pieters, L. J. Med. Chem. 2002, 45(16), 3497-3508.
170. Shuren, Z.; Thomas H. H.; Dennis E. K.; Lin, A. J. J. Med. Chem. 2002, 45(16), 3491 -3496.
171. Jian G.; Dennis E. K.; Lucia G.; Zhang, Q.; Milhous, W. K.; Lin, A. J. J. Med. Chem. 2002, 45, 2741-2748.
172. Anthony D. W.; Eva, G.; König, G. M.; Kaminsky, R. J. Med. Chem. 2002, 45, 3067 -3072.
173. Arzel, E.; Rocca, Philippe, P.; Mehdi, G. L.; Frappier, F.; Françoise, G.; Christiane, G.; Francis, M.; Alain G.; Quéguiner, G. J. Med. Chem. 2001, 44, 949-960.
174. Paul, M. O'Neill.; Mukhtar, A.; Paul A. S.; Randle, L. E.; Stephen, H.; Stephen, A.; Ward, R. C. S.; Jamie F. B.; Ian A. O'Neil.; James L. M.; Ruth H. H.; Peter A. W.; Patrick G. B.; Kevin P. B. J. Med. Chem. 2003, 46, 4933-4945.
175. Muhammad, I.; Li, Xing-C.; Jacob, M R.; Tekwani, B. L.; Dunbar, D. C.; Ferreira, D.; J. Nat. Prod. 2003, 66, 804-909.
176. Hu, Jin-F., John A. Schetz.; Michelle K.; Jiang-Nan Peng Kenny, K. H.; Ang, H. F.; Chung Y. L.; Siew, B. N.; Antony, D. B.; Scott, P. W.; Mark, T. H. J. Nat. Prod. 2002, 65, 476-480.
177. Zhang, H. J.; Pamela, A. T.; Hoang, V. D.; Tan, G. T.; Hung, N. V.; Xuan, L. T.; Huong, L. M.; Thao, N. M. C. D.; Thi, D.; Soejarto, D.; Fong, H. H. S.; Pezzuto, J. M. J. Nat. Prod. 2001, 64, 772-777
178. Dominguez, J. N.; Charris, J. F.; Lobo, G.; Domingez, de N. G.; Moreno, M. M.; Riggione, F.; Sanchez, E.; Olson, J. Rosenthal, P. J. Eur. J. Med. Chem. 2001, 36, 555-560
179. Giancarlo, A. B.; Eric, R.; Patrick G. B.; Michèle, C,; Henri, V.; Stephen, A. W. Antimicrob. Agents and Chemother. 2003, 47., 2584-2589.
180. Herbert Rodrigues Goulart, Emília A. Kimura, Valnice J. Peres, Alicia S. Couto, Fulgencio A. Aquino Duarte, and Alejandro M. Katzin Antimicrobial Agents and Chemotherap, 2004, 48, 2502-2509.