Proton pumping in the bc1 complex: A new gating mechanism that prevents short circuits

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1757, Issue 8, 2006, Pages 1019-1034

  Crofts, Antony R ^a   Lhee, Sangmoon ^a   Crofts, Stephanie B ^a   Cheng, Jerry ^a   Rose, Stuart ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

PEWY span; bc1 complex; Proton circuit; Q cycle; Qo site; Rhodobacter sphaeroides; Superoxide

Indexed keywords

CITRININ; CYTOCHROME C; HEME; HYDROQUINONE; IRON SULFUR PROTEIN; PROTON PUMP; SEMIQUINONE; STIGMATELLIN; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; BACTERIAL PROTEIN; PROTON;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BINDING SITE; CHANNEL GATING; DRUG MECHANISM; ELECTRON TRANSPORT; ENZYME METABOLISM; ENZYME STABILITY; HYDROGEN BOND; MATHEMATICAL COMPUTING; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; THERMODYNAMICS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; RHODOBACTER SPHAEROIDES; TRANSPORT AT THE CELLULAR LEVEL;

RHODOBACTER SPHAEROIDES;

BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; ELECTRON TRANSPORT COMPLEX III; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTONS; RHODOBACTER SPHAEROIDES;

EID: 33748913718     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2006.02.009     Document Type: Review

References (98)

1. 1 complex: what is there left to argue about?. In: Wikstrom M. (Ed). Biophysical and Structural Aspects of Bioenergetics (2005), Royal Society of Chemistry, Cambridge 121-155
2. 1 complex. FEBS Lett. 545 (2003) 39-46
3. 6f complex. Biochemistry 43 (2004) 5921-5929
4. Crofts A.R. The Q-cycle-A personal perspective. Photosynth. Res. 80 (2003) 223-243
5. 1 complex. Biochemistry 41 (2002) 7866-7874
6. 1 complex. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10021-10026
7. Wikström M.K.F., and Berden J. Oxidoreduction of cytochrome b in the presence of antimycin. Biochim. Biophys. Acta 283 (1972) 403-420
8. Slater E.C. The cytochrome b paradox, the BAL-labile factor and the Q-cycle. In: Skulachev V.P., and Hinkle P.C. (Eds). Chemiosmotic Proton Circuits in Biological Membranes (1981), Addison-Wesley Publ. Co., Reading, Mass 69-104
9. 1 complex in the respiratory chain: proton motive ubiquinone cycle. FEBS Lett. 56 (1975) 1-6
10. Mitchell P. Possible molecular mechanisms of the protonmotive function of cytochrome systems. J. Theor. Biol. 62 (1976) 327-367
11. Garland P.B., Clegg R.A., Boxer D., Downie J.A., and Haddock B.A. Proton-translocating nitrate reductase of Escherichia coli. In: Quagliariello E., Papa S., Palmieri F., Slater E.C., and Siliprandi N. (Eds). Electron Transfer Chains and Oxidative Phosphorylation (1975), North-Holland Publishing Co., Amsterdam, The Netherlands 351-358
12. Crofts A.R., Meinhardt S.W., Jones K.R., and Snozzi M. The role of the quinone pool in the cyclic electron-transfer chain of Rhodopseudomonas sphaeroides A modified Q-cycle mechanism. Biochim. Biophys. Acta (BBA)-Bioenergetics 723 (1983) 202-218
13. Crofts A.R. The mechanism of ubiquinol:cytochrome c oxidoreductases of mitochondria and of Rhodopseudomonas sphaeroides. In: Martonosi A.N. (Ed). The Enzymes of Biological Membranes (1985), Plenum Publ. Corp., New York 347-382
14. 1 complex. J. Biol. Chem. 278 (2003) 36191-36201
15. 1 complex from bovine heart mitochondria. Science 277 (1997) 60-66
16. 1. Nature (London) 392 (1998) 677-684
17. 1 complex-function in the context of structure. Annu. Rev. Physiol. (2004) 689-733
18. Jackson J.B., and Crofts A.R. The high energy state in chromatophores from Rhodopseudomonas spheroides. FEBS Lett. 4 (1969) 185-189
19. Jackson J.B., and Crofts A.R. The kinetics of light induced carotenoid changes in Rhodopseudomonas spheroides and their relation to electrical field generation across the chromatophore membrane. Eur. J. Biochem. 18 (1971) 120-130
20. 2 oxidoreductase complex of Rhodopseudomonas sphaeroides. Biochim. Biophys. Acta (BBA)-Bioenergetics 766 (1984) 322-333
21. Venturoli G., Virgili M., Melandri B.A., and Crofts A.R. Kinetic measurements of electron transfer in coupled chromatophores from photosynthetic bacteria: a method of correction for the electrochromic effects. FEBS Lett. 219 (1987) 477-484
22. 2 oxidoreductase of R. sphaeroides: a steady state approach. PhD thesis Biophysics, pp. 143, University of Illinois at Urbana-Champaign 1989.
23. 2 oxidoreductase of Rb. sphaeroides in the steady state. In: Baltscheffsky M. (Ed). Current Research in Photosynthesis vol. III (1990), Kluwer Academic Publishers, Dordrecht 287-290
24. 2 oxidoreductase of Rhodobacter sphaeroides. In: Lenaz G., Barnabei O., Rabbi A., and Battino M. (Eds). Highlights in Ubiquinone Research (1990), Taylor and Francis, London 98-103
25. Lemasters J.J., and Billica W.H. Non-equilibrium thermodynamics of oxidative phosphorylation by inverted inner membrane vesicles of rat liver mitochondria. J. Biol. Chem. 256 (1981) 12949-12957
26. 1 complex in Rhodobacter sphaeroides. J. Biol. Chem. 274 (1999) 33931-33944
27. 2 oxidoreductase?. Photosynth. Res. 22 (1989) 69-87
28. 1 and its implications for energy conversion. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4567-4572
29. 1 complex. J. Biol. Chem. 274 (1999) 7146-7152
30. 1 complex. J. Biol. Chem. 273 (1998) 27953-27959
31. 1 complex. Biochemistry 42 (2003) 1499-1507
32. 1 complex: the role of the iron sulfur protein, and its mobility. Biochemistry 38 (1999) 15791-15806
33. 1 complex. Biochemistry 38 (1999) 15827-15839
34. 1 complex. Biophys. J. 77 (1999) 1753-1768
35. 1 complex: effects of pH, temperature, and driving force. J. Biol. Chem. 277 (2002) 31072-31078
36. 1 complex: the different domains of the quinol binding pocket, and their role in mechanism, and the binding of inhibitors. Biochemistry 38 (1999) 15807-15826
37. 1 complex. J. Biol. Chem. 277 (2002) 2464-3470
38. 1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition. Biochemistry 41 (2002) 11692-11702
39. 1 complex. Science 281 (1998) 64-71
40. o site inhibitor bound. J. Biol. Chem. 278 (2003) 31303-31311
41. 1 complex. FEBS Lett. 555 (2003) 13-20
42. 2 in Rhodopseudomonas sphaeroides. Biochim. Biophys. Acta (BBA)-Bioenergetics 592 (1980) 445-460
43. Link T.A., Haase U., Brandt U., and von Jagow G. What information do inhibitors provide about the structure of the hydroquinone oxidation site of ubiquinol:cytochrome c oxidoreductase. J. Bioenerg. Biomembranes 25 (1993) 221-232
44. o site model. Biochemistry 31 (1992) 3144-3158
45. 1 complex: is the mechanism spring-loaded?. Biochim. Biophys. Acta 1555 (2002) 48-53
46. o-site: what type of mechanism can account for the high activation barrier?. Biochim. Biophys. Acta 1459 (2000) 456-466
47. 1 complex controls the rate of ubihydroquinone oxidation. Biochim. Biophys. Acta 1655 (2004) 77-92
48. i site. Biochemistry 42 (2003) 9067-9080
49. 1 complex. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10021-10026
50. v fragment. Structure 8 (2000) 669-684
51. 1 complex and in membranes. FEBS Lett. 440 (1998) 409-413
52. 1 complexes containing site-directed mutants of the Rieske iron-sulfur protein. Biochim. Biophys. Acta 1365 (1998) 125-134
53. 1 complex by ATR-FTIR spectroscopy. Biochemistry 44 (2005) 4230-4237
54. Evans E.H., and Crofts A.R. In situ characterization of photosynthetic electron transport in Rhodopseudomonas capsulata. Biochim. Biophys. Acta 357 (1974) 89-102
55. 2, and its coupled reactions. Biochim. Biophys. Acta 462 (1977) 731-747
56. Snozzi M., and Crofts A.R. Electron transport in chromatophores from Rhodopseudomonas sphaeroides GA fused with liposomes. Biochim. Biophys. Acta (BBA)-Bioenergetics 766 (1984) 451-463
57. 1 complex by blocking a protonatable group. J. Biol. Chem. 270 (1995) 25001-25006
58. Brandt U., and Okun J.G. Role of deprotonation events in ubihydroquinone: cytochrome c oxidoreductase from bovine heart and yeast mitochondria. Biochemistry 36 (1997) 11234-11240
59. 1 complex. Biochemistry 39 (2000) 7436-7444
60. Gurbiel R.J., Ohnishi T., Robertson D., Daldal F., and Hoffman B.M. Q-Band ENDOR spectra of the Rieske protein from Rhodobacter capsulatus ubiquinol-cytochrome c oxidoreductase show two histidines coordinated to the [2Fe-2S] cluster. Biochemistry 30 (1991) 11579-11584
61. 1 complex determined by MAD phasing at 1.5 Å resolution. Structure 4 (1996) 567-579
62. Rich P.R. In: Kotyk A., et al. (Ed). Highlights of Modern Biochemistry (1989), V.S.P. Publishers, Prague 903-912
63. o site inhibitors: consequences for ubiquinone and ubiquinol affinity and catalysis. Biochemistry 29 (1990) 11249-11260
64. 1 complex). J. Biol. Chem. 266 (1991) 19958-19964
65. 1 complex, probed by 1D and 2D Electron Spin Echo Envelope Modulation. J. Biol. Chem. 277 (2002) 4605-4608
66. 1 complex. Biochemistry 38 (1999) 14973-14980
67. Cooley J.W., Roberts A.G., Bowman M.K., Kramer D.M., and Daldal F. The raised midpoint potential of the [2Fe2S] cluster of cytochrome bc1 is mediated by both the Q(o) site occupants and the head domain position of the Fe-S protein subunit. Biochemistry 43 (2004) 2217-2227
68. 1 complex. Biochemistry 41 (2002) 14372-14382
69. 1 complex. J. Biol. Chem. 277 (2002) 3464-3470
70. Boveris A. Determination of the production of superoxide radicals and hydrogen-peroxide in mitochondria. Methods Enzymol. 105 (1984) 429-435
71. Muller F. The nature and mechanism of superoxide production by the electron transport chain: its relevance to aging. J. Am. Aging Assoc. 23 (2000) 227-253
72. Turrens J.F., Alexandre A., and Lehninger A.L. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 237 (1985) 408-414
73. Moser C.C., and Dutton P.L. Engineering protein structure for electron transfer function in photosynthetic reaction centers. Biochim. Biophys. Acta 1101 (1992) 171-176
74. Osyczka A., Moser C.C., and Dutton P.L. Fixing the Q-cycle. Trends Biochem. Sci. 30 (2005) 176-182
75. Osyczka A., Moser C.C., Daldal F., and Dutton P.L. Reversible redox energy coupling in electron transfer chains. Nature 427 (2004) 607-612
76. Denke E., Merbitzzahradnik T., Hatzfeld O.M., Snyder C.H., Link T.A., and Trumpower B.L. Alteration of the midpoint potential of the Rieske iron-sulfur protein by changes of amino acids forming H-bonds to the iron-sulfur cluster. J. Biol. Chem. 273 (1998) 9085-9093
77. 1 complex of Paracoccus denitrificans. Eur. J. Biochem. 255 (1998) 100-106
78. 1 complex. Biochim. Biophys. Acta 1275 (1996) 61-69
79. 1 complex: the "proton-gated affinity change" mechanism. FEBS Lett. 412 (1997) 257-264
80. 1 complex by proton-gated charge transfer. FEBS Lett. 387 (1996) 1-6
81. Zu Y., Manon M.-J., Couture M.M.-J., Kolling D.R.J., Crofts A.R., Eltis L.D., Fee J.A., and Hirst J. The reduction potentials of Rieske clusters: the importance of the coupling between oxidation state and histidine protonation state. Biochemistry 42 (2003) 12400-12408
82. Korshunov S.S., Skulachev V.P., and Starkov A.A. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416 (1997) 15-18
83. 1 complex probed by superoxide production. Biochemistry 42 (2003) 6493-6499
84. 1 complex. Biochim. Biophys. Acta 1555 (2002) 166-173
85. 1 complex. Biochim. Biophys. Acta 1555 (2002) 65-70
86. 1 complex. J. Biol. Chem. 275 (2000) 13535-13554
87. 1 complex. Biochim. Biophys. Acta 1365 (1998) 261-268
88. 1 and the voltage generation. Biochim. Biophys. Acta 1553 (2002) 177-182
89. 1 complex: reaction mechanism and prevention of short-circuiting. Biochim. Biophys. Acta 1709 (2005) 5-34
90. 1 complex from bovine heart. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 8026-8033
91. 1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 2800-2805
92. 1 complex. Biochemistry 44 (2005) 10520-10532
93. 1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern. J. Mol. Biol. 351 (2005) 573-597
94. 1 complex-Mechanistic and physiological implications. J. Biol. Chem. 280 (2005) 34654-34660
95. Rich P.R. The quinone chemistry of bc complexes. Biochim. Biophys. Acta 1658 (2004) 165-171
96. Zhang L., Li Z., Quinn B., Yu L., and Yu C.-A. Nonoxidizable ubiquinol derivatives that are suitable for the study of the ubiquinol oxidation site in the cytochrome bc1 complex. Biochim. Biophys. Acta 1556 (2002) 226-232
97. Meinhardt S.W., and Crofts A.R. The role of cytochrome b-566 in the electron transfer chain of Rhodopseudomonas sphaeroides. Biochim. Biophys. Acta 723 (1983) 219-230
98. G. Lenaz, M. Degli Esposti, Physical properties of ubiquinones in model systems and membranes. In G. Lenaz (Ed.), Coenzyme Q, Wiley and Sons, Ltd., Chichester, U.K, pp. 83-105.