Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone

Molecular and Biochemical Parasitology

Volumn 104, Issue 2, 1999, Pages 185-194

  Syafruddin, D ^a,b   Siregar, Josephine E ^a   Marzuki, Sangkot ^a  

^a EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^b HASANUDDIN UNIVERSITY   (Indonesia)

Author keywords

Atovaquone resistance; Cytochrome b gene mutation; Plasmodium berghei

Indexed keywords

ATOVAQUONE; CYTOCHROME B; MITOCHONDRIAL DNA; OXIDOREDUCTASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CLONE; CONTROLLED STUDY; DRUG RESISTANCE; EXPERIMENTAL INFECTION; GENE MUTATION; GENE SEQUENCE; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITEMIA; PLASMODIUM BERGHEI; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; ATOVAQUONE; BASE SEQUENCE; CYTOCHROME B GROUP; DNA, MITOCHONDRIAL; DNA, PROTOZOAN; DRUG RESISTANCE; GENES, PROTOZOAN; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; NAPHTHOQUINONES; PLASMODIUM BERGHEI; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ANALYSIS, DNA;

MAMMALIA; PLASMODIUM BERGHEI;

EID: 0032738420     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00148-6     Document Type: Article

References (23)

1. Ellis J.E. Coenzyme Q homologs in parasitic protozoa as target for chemotherapeutic attack. Parasitol. Today. 10:1994;296-302.
2. Araujo F.G., Huskinson J., Remington J.S. Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii. Antimicrob. Agent. Chemother. 35:1991;293-299.
3. Gay F., Bustos D., Traore B., Jardinel C., Southammavong M., Ciceron L. et al. In vitro response of Plasmodium falciparum to atovaquone and correlation with other antimalarials: comparison between African and Asian strains. Am. J. Trop. Med. Hyg. 56:1997;315-317.
4. Looareesuwan S., Viravan C., Webster H.K., Kyle D.E., Hutchinson D.B., Canfield C.J. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54:1996;62-66.
5. Roberts H., Choo W.M., Smith S.C., Marzuki S., Linnane A.W., Porter T.H. et al. The site of inhibition of mitochondrial electron transfer by coenzyme Q analogues. Arch. Biochem. Biophys. 191:1978;306-315.
6. Fry M., Pudney M. The site of action of the antimalarial hydroxynaphthoquinones 2-{trans-4(4′-chlorophenyl)cyclohexyl}-3-hydroxy-1,4-naphthoquinone (566C80). Biochem. Pharmacol. 43:1992;1545-1553.
7. Srivastava I.K., Rottenberg H., Vaidya A.B. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J. Biol. Chem. 272:1997;3961-3966.
8. Colson A.M. Random mutant generation and its utility in uncovering structural and functional features of cytochrome b in Saccharomyces cerevisiae. J. Bioenerg. Biomembr. 25:1993;211-220.
9. Vaidya AB, Akella R, Suplick K. Sequences similar to genes for two mitochondrial proteins and portions of ribosomal RNA in tandemly arrayed 6-kilobase-pair DNA of a malarial parasite, Mol Biochem Parasitol 1989;35:97-108; Corrigendum Mol Biochem Parasitol 1990;39:295-296.
10. Vaidya AB, Akella R, Suplick K. Sequences similar to genes for two mitochondrial proteins and portions of ribosomal RNA in tandemly arrayed 6-kilobase-pair DNA of a malarial parasite, Mol Biochem Parasitol 1989;35:97-108; Corrigendum Mol Biochem Parasitol 1990;39:295-296.
11. Suplick K., Akella R., Saul A., Vaidya A.B. Molecular cloning and partial sequence of a 5.8-kilobase-pair repetitive DNA from Plasmodium falciparum. Mol. Biochem. Parasitol. 30:1988;289-290.
12. Feagin J.E., Werner E., Gardner M.J., Williamson D.H., Wilson R.J.M. The 6-kb element of Plasmodium falciparum encodes mitochondrial cytochrome gene. Nucleic Acids. Res. 20:1992;879-887.
13. Vaidya A.B., Lashgari M.S., Pologe L.G., Morrisey J. Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones. Mol. Biochem. Parasitol. 58:1993;33-42.
14. Geary T.G., Divo A.A., Jensen J.B. An in vitro assay system for the identification of potential antimalarial drug. J. Parasitol. 69:1983;577-583.
15. Zuckerman A., Spira D., Hamburger J. A procedure for harvesting of mammalian plasmodia. Bull. WHO. 37:1967;431-436.
16. Trumpower B.L., Gennis R.B. Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: The enzymology coupling electron transfer reactions to transmembrane proton translocation. Annu. Rev. Biochem. 63:1994;675-716.
17. Brasseur R. Calculation of the three-dimensional structure of Saccharomyces cerevisiae cytochrome b inserted in a lipid matrix. J. Biol. Chem. 263:1988;12571-12575.
18. i site in the mitochondrial ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae. J. Biol. Chem. 263:1988;12564-12570.
19. di Rago J.P., Coppee J.Y., Colson A.M. Molecular basis for resistance to myxothiazol, mucidin (strobilurin A), and stigmatellin. Cytochrome b inhibitors acting at the center o of the mitochondrial ubiquinol-cytochrome c-reductase in Saccharomyces cerevisiae. J. Biol. Chem. 264:1989;14543-14548.
20. Howell N., Gilbert K. Mutational analysis of the mouse mitochondrial cytochrome b gene. J. Mol. Biol. 203:1988;607-618.
21. di Rago J.P., Perera J., Colson A.M. DNA sequence analysis of diuron-resistant mutations in the mitochondrial cytochrome b gene of Saccharomyces cerevisiae. FEBS Lett. 208:1986;208-210.
22. 1 comlex of Rhodobacter capsulatus. EMBO J. 8:1989;3951-3963.
23. 1 complexes. Arch. Biochem. Biophys. 200:1980;387-395.