Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 1945-1967

  Boa, Andrew N ^a   Canavan, Shane P ^a   Hirst, Paul R ^a,c   Ramsey, Christopher ^b   Stead, Andrew M W ^b,d   McConkey, Glenn A ^b  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c Onyx Scientific Limited   (United Kingdom)

^d UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 PHENYL 3H FURO[3,4 C]QUINOLIN 1 ONE; 6 (1 HYDROXY 2 MORPHOLIN 4 YLETHYL) 2 PHENYLQUINOLINE 4 CARBOXYLIC ACID DIISOPROPYLAMIDE; 6 (2 DIETHYLAMINO 1 HYDROXYETHYL) 2 PHENYLQUINOLINE 4 CARBOXYLIC ACID DIISOPROPYLAMIDE; 8 MORPHOLIN 4 YLMETHYL 2 PHENYLQUINOLINE 4 CARBOXYLIC ACID ETHYL ESTER; ANTIMALARIAL AGENT; BREQUINAR; CARBOXYLIC ACID; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 13844317355     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.017     Document Type: Article

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