Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 8, 2002, Pages 2435-2441

  Peters, Jennifer M ^a   Chen, Nanhua ^a   Gatton, Michelle ^a   Korsinczky, Michael ^a   Fowler, Elizabeth V ^a   Manzetti, Sergio ^a   Saul, Allan ^a   Cheng, Qin ^a  

^a AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; CYTOCHROME B; NAPHTHOQUINONE; PROTOZOAL DNA; UBIQUINONE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FITNESS; GENE MUTATION; MALARIA; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHROMOSOME MAP; DNA FINGERPRINTING; DNA SEQUENCE; DRUG EFFECT; DRUG RESISTANCE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SUBSTITUTION; ANIMAL; ANTIMALARIALS; BINDING SITES; CHROMOSOME MAPPING; CYTOCHROME B; DNA FINGERPRINTING; DNA, PROTOZOAN; DRUG RESISTANCE; MODELS, MOLECULAR; MUTATION; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; UBIQUINONE; ANIMALS; ATOVAQUONE; CYTOCHROME B GROUP;

EID: 0035991833     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.8.2435-2441.2002     Document Type: Article

References (38)

1. Plasmodium falciparum parasites in French Guiana: Limited genetic diversity and high selfing rate
2. Unstable malaria in Sudan: The influence of the dry season: Clone multiplicity of Plasmodium falciparum infections in individuals exposed to variable levels of disease transmission
3. Three molecules of ubiquinone bind specifically to mitochondrial cytochrome bc1 complex
4. GROMACS: A message-passing parallel molecular dynamics implementation
5. Molecular dynamics with coupling to an external bath
6. Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis
7. Measurement of Plasmodium falciparum growth rate in vivo: A test of malaria vaccines
8. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
9. Physicochemical aspects of the movement of the Rieske iron sulfur protein during quinol oxidation by the bc(1) complex from mitochondria and photosynthetic bacteria
10. Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations
11. A molecular marker for chloroquine-resistant falciparum malaria
12. Plasmodium vivax synonymous substitution frequencies, evolution and population structure deduced from diversity in AMA 1 and MSP 1
13. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
14. Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4′-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566c80)
15. Features of recrudescent choloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control
16. Development and validation of a genetic algorithm for flexible docking
17. Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum
18. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located in a putative drug-binding site
19. Synchronization of Plasmodium falciparum erythrocytic stages in culture
20. 7H8/6, a multicopy DNA probe for distinguishing isolates of Plasmodium falciparum
21. GROMACS 3.0: A package for molecular simulation and trajectory analysis
22. Changes in the resistance of Plasmodium falciparum to chloroquine in Hainan, China
23. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
24. Gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in West Africa
25. Persistence of drug-resistant malaria parasites
26. Numerical integration of the Cartesian equations of motion of a system with constraints; molecular dynamics of n-alkanes
27. Purification of mature schizonts of Plasmodium falciparum on colloidal silica gradients
28. Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis
29. The GROMOS biomolecular simulation program package
30. Effect of pyrimethamine resistance on sporogony in a Plasmodium berghei/Anopheles stephensi model
31. Atovaquone, a broad-spectrum antiparasitic drug, collapses mitochondria membrane potential in a malaria parasite
32. Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern Vietnam
33. Human malaria parasites in continuous culture
34. Relative fitness of three organophosphate-resistant strains of Culex pipiens pallens (Diptera: Culicidae)
35. Chloroquine resistance of Plasmodium falciparum: A biological advantage?
36. Preventing antimalarial drug resistance through combinations
37. Role of ribosomal protein S12 in peptide chain elongation: Analysis of pleiotropic, streptomycine-resistant mutants of Escherichia coli