Aminonaphthoquinones - A novel class of compounds with potent antimalarial activity against Plasmodium falciparum

Pharmacological Research

Volumn 43, Issue 4, 2001, Pages 363-367

  Kapadia, Govind J ^a   Azuine, Magnus A ^a   Balasubramanian, Venkataraman ^a   Sridhar, Rajagopalan ^b  

^a HOWARD UNIVERSITY   (United States)

^b HOWARD UNIVERSITY CANCER CENTER   (United States)

Author keywords

Amino 1,2 naphthoquinones; Amino 1,4 naphthoquinones; Antimalarials

Indexed keywords

2 AMINO 3 CHLORO 1,4 NAPHTHOQUINONE; AMINONAPHTHOQUINONE DERIVATIVE; NAPHTHOQUINONE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; HIGH RISK POPULATION; IC 50; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; VECTOR CONTROL;

EID: 0034964684     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2000.0791     Document Type: Article

References (24)

1. Malaria
2. Antimalarial drug resistance and combination chemotherapy
3. Impact of chloroquine resistance on malaria mortality
4. Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy
5. Chloroquine in Africa: Critical assessment and recommendations for monitoring and evaluating chloroquine therapy efficacy in sub-Saharan Africa
6. Atovaquone - A novel broad-spectrum anti-infective drug
7. In vitro response of Plasmodium falciparum to atovaquone and correlation with other antimalarials: Comparison between African and Asian strains
8. In vitro activity of atovaquone against the African isolates and clones of Plasmodium falciparum
9. Naphthoquinone antimalarials. I. General survey
10. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity
11. In vitro activity of 2-cycloalkyl-3-hydroxy-1,4-naphthoquinones against Theilera, Eimeria and Plasmodia species
12. Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr eariy antigen activation assay and in mouse skin carcinogenesis
13. Quantitative assessment of antimicrobial activity by semiautomated microdilution technique
14. In vitro activities of and mechanisms of resistance to antifol antimalarial drugs
15. Akuammine: An antimalarial indolemonoterpene alkaloid of Picralma nitida seeds
16. Malaria disaster in Africa
17. Lapinone, menoctone, hydroxyquinolines and similar structures
18. The fungicidal activity of substituted 1,4-naphthoquinones. Part II: Alkoxy, phenoxy and acryloxy derivatives
19. The fungicidal activity of substituted 1,4-naphthoquinones. Part III: Amino, anilino and acylamino derivatives
20. Potential antimalariai agents. Derivatives of 2-chloro-1,4-naphthoquinone
21. Antiprotozoal quinones. II. Synthesis of 4-amino-1,2-naphthoquinones and related compounds as potential antimalarials