Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells

Biochemical Pharmacology

Volumn 73, Issue 3, 2007, Pages 427-439

  González Aragón, David ^a   Ariza, Julia ^a   Villalba, José M ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Cell cycle; Dicoumarol; Mitochondria; NQO1; Pyrimidines biosynthesis; Superoxide

Indexed keywords

5 METHOXY 1,2 DIMETHYL 3 [(4 NITROPHENOL)METHYL]INDOLE 4,7 DIONE; CYTOCHROME B560; DECYLUBIQUINOL; DICOUMAROL; DIHYDROOROTATE DEHYDROGENASE; ES 936; OROTIC ACID; PYRIMIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) INHIBITOR; SUCCINIC ACID; SUPEROXIDE; THENOYLTRIFLUOROACETONE; UBIQUINOL CYTOCHROME C REDUCTASE; URIDINE;

ARTICLE; BINDING SITE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL STRAIN HL 60; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MYELOID LEUKEMIA; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS;

DICUMAROL; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); PYRIMIDINES; S PHASE; SUPEROXIDES; THENOYLTRIFLUOROACETONE;

EID: 33845757115     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.10.016     Document Type: Article

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