Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1761, Issue 2, 2006, Pages 205-212

  Bisogno, Tiziana ^a   Cascio, Maria Grazia ^a,c   Saha, Bijali ^b   Mahadevan, Anu ^b   Urbani, Paolo ^c   Minassi, Alberto ^d   Appendino, Giovanni ^d   Saturnino, Carmela ^c   Martin, Billy ^e   Razdan, Raj ^b   Di Marzo, Vincenzo ^a  

^a CNR   (Italy)

^b ORGANIX INC   (United States)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Arachidonoylglycerol; Cannabinoid; Diacylglycerol; Inhibitor; Lipase

Indexed keywords

1 OLEOYL 2 ARACHIDONOYLGLYCEROL; 2 ARACHIDONOYLGLYCEROL; 2 METHYL 4 HYDROXYBENZYL N ARACHIDONOYLETHANOLAMINE; 4 HYDROXYBENZIL N OLEOYLETHANOLAMIDE; ACYLGLYCEROL LIPASE; ACYLPHOSPHATIDYLETHANOLAMINE; ANANDAMIDE; ARACHIDONOYL 5 HYDROXYTRYPTAMINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ENDOCANNABINOID; ESTER DERIVATIVE; FATTY ACID AMIDASE; LIPOPROTEIN LIPASE; LIVER ENZYME; METHYLARACHIDONOYLFLUOROPHOSPHONATE; O 3453; O 3640; O 3696; O 3841; O ETHYL O 4 NITROPHENYLOLEYLPHOSPHONATE; O ETHYL O OLEYLOLEYLPHOSPHONATE; O ETHYLOLEYLPHOSPHONATE; O,O DIETHYLOLEYLPHOSPHONATE; OCTADEC 9 ENOIC ACID 1 (FLUOROMETHOXYPHOSPHINOYLMETHYL)HEXYL ESTER; OCTADEC 9 ENOIC ACID 1 (FLUOROMETHYLPHOSPHORYLOXYMETHYL)PROPYL ESTER; OCTADEC 9 ENOIC ACID 1 METHOXYMETHYL 2 (FLUOROMETHYLPHOSPHORYLOXYMETHYL) PROPYL ESTER; OCTADEC 9 ENOIC ACID 2 (METHOXYFLUOROPHOSPHINOYL) 1 OCTADEC 9 ENOYLOXYMETHYLETHYL ESTER; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE D; PHOSPHONIC ACID DERIVATIVE; RECOMBINANT ENZYME; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; UP 100; UP 101; UP 104; UP 99;

ARTICLE; BIOSYNTHESIS; CELL FRACTIONATION; CELL MEMBRANE; CELL STRAIN COS1; CYTOSOL; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME ACTIVITY; ENZYME SUBSTRATE; EVALUATION; GENE OVEREXPRESSION; IC 50; PRIORITY JOURNAL; WILD TYPE;

AMIDOHYDROLASES; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENDOCANNABINOIDS; HUMANS; LACTONES; LIPASE; LIPOPROTEIN LIPASE; LIVER; MOLECULAR STRUCTURE; MONOACYLGLYCEROL LIPASES; OLEIC ACIDS; PHOSPHOLIPASE D; RATS; RECOMBINANT PROTEINS;

EID: 33646472897     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2005.12.009     Document Type: Article

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