-
1
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W.G. and Ratcliffe, P.J. (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
2
-
-
35048875691
-
Evaluation of HIF-1 inhibitors as anticancer agents
-
Semenza, G.L. (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today 12, 853-859
-
(2007)
Drug Discov. Today
, vol.12
, pp. 853-859
-
-
Semenza, G.L.1
-
3
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong, H., De Marzo, A.M., Laughner, E., Lim, M., Hilton, D.A., Zagzag, D., Buechler, P., Isaacs, W.B., Semenza, G.L. and Simons, J.W. (1999) Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59, 5830-5835
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
5
-
-
22244440847
-
Proline hydroxylation and gene expression
-
Kaelin, W.G. (2005) Proline hydroxylation and gene expression. Annu. Rev. Biochem. 74, 115-128
-
(2005)
Annu. Rev. Biochem
, vol.74
, pp. 115-128
-
-
Kaelin, W.G.1
-
6
-
-
33646175288
-
The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling
-
Berra, E., Ginouvès, A. and Pouysségur, J. (2006) The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. EMBO Rep. 7, 41-45
-
(2006)
EMBO Rep
, vol.7
, pp. 41-45
-
-
Berra, E.1
Ginouvès, A.2
Pouysségur, J.3
-
7
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K.I. and Myllyharju, J. (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278, 30772-30780
-
(2003)
J. Biol. Chem
, vol.278
, pp. 30772-30780
-
-
Hirsilä, M.1
Koivunen, P.2
Günzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
8
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
Taylor, M.S. (2001) Characterization and comparative analysis of the EGLN gene family. Gene 275, 125-132
-
(2001)
Gene
, vol.275
, pp. 125-132
-
-
Taylor, M.S.1
-
9
-
-
17944375360
-
-
Epstein, A.C., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O'Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A. et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54
-
Epstein, A.C., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O'Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A. et al. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54
-
-
-
-
11
-
-
44349091967
-
Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member
-
Hughes, B.T. and Espenshade, P.J. (2008) Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J. 27, 1491-1501
-
(2008)
EMBO J
, vol.27
, pp. 1491-1501
-
-
Hughes, B.T.1
Espenshade, P.J.2
-
12
-
-
34249824288
-
Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly
-
Keskiaho, K., Hieta, R., Sormunen, R. and Myllyharju, J. (2007) Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly. Plant Cell 19, 256-269
-
(2007)
Plant Cell
, vol.19
, pp. 256-269
-
-
Keskiaho, K.1
Hieta, R.2
Sormunen, R.3
Myllyharju, J.4
-
13
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
-
Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D. and Pouyssègur, J. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22, 4082-4090
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouvès, A.3
Volmat, V.4
Roux, D.5
Pouyssègur, J.6
-
14
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff, R.J., Tian, Y.M., Raval, R.R., Turley, H., Harris, A.L., Pugh, C.W., Ratcliffe, P.J. and Gleadle, J.M. (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 279, 38458-38465
-
(2004)
J. Biol. Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
Pugh, C.W.6
Ratcliffe, P.J.7
Gleadle, J.M.8
-
15
-
-
32244434382
-
An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity
-
Cervera, A.M., Apostolova, N., Luna-Crespo, F., Sanjuan-Pla, A., Garcia-Bou, R. and McCreath, K.J. (2006) An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity. Cancer Lett. 233, 131-138
-
(2006)
Cancer Lett
, vol.233
, pp. 131-138
-
-
Cervera, A.M.1
Apostolova, N.2
Luna-Crespo, F.3
Sanjuan-Pla, A.4
Garcia-Bou, R.5
McCreath, K.J.6
-
16
-
-
33745525617
-
Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation
-
Tian, Y.M., Mole, D.R., Ratcliffe, P.J. and Gleadle, J.M. (2006) Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. Biochem. J. 397, 179-186
-
(2006)
Biochem. J
, vol.397
, pp. 179-186
-
-
Tian, Y.M.1
Mole, D.R.2
Ratcliffe, P.J.3
Gleadle, J.M.4
-
17
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak, M.A., Armour, S.M., MacKenzie, E.D., Boulahbel, H., Watson, D.G., Mansfield, K.D., Pan, Y., Simon, M.C., Thompson, C.B. and Gottlieb, E. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7, 77-85
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
18
-
-
34247553146
-
Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
-
MacKenzie, E.D., Selak, M.A., Tennant, D.A., Payne, L.J., Crosby, S., Frederiksen, C.M., Watson, D.G. and Gottlieb, E. (2007) Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 27, 3282-3289
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 3282-3289
-
-
MacKenzie, E.D.1
Selak, M.A.2
Tennant, D.A.3
Payne, L.J.4
Crosby, S.5
Frederiksen, C.M.6
Watson, D.G.7
Gottlieb, E.8
-
19
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G. and Thompson, C.B. (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
20
-
-
34347402459
-
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
-
Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R. and Lazebnik, Y. (2007) Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J. Cell Biol. 178, 93-105
-
(2007)
J. Cell Biol
, vol.178
, pp. 93-105
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
-
21
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., Loewith, R. and Hall, M.N. (2006) TOR signaling in growth and metabolism. Cell 124, 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
22
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D.A. and Sabatini, D.M. (2007) Defining the role of mTOR in cancer. Cancer Cell 12, 9-22
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
23
-
-
36749047009
-
Amino acids and mTOR signalling in anabolic function
-
Proud, C.G. (2007) Amino acids and mTOR signalling in anabolic function. Biochem. Soc. Trans. 35, 1187-1190
-
(2007)
Biochem. Soc. Trans
, vol.35
, pp. 1187-1190
-
-
Proud, C.G.1
-
24
-
-
27544500981
-
Growing roles for the mTOR pathway
-
Sarbassov, D.D., Ali, S.M. and Sabatini, D.M. (2005) Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603
-
(2005)
Curr. Opin. Cell Biol
, vol.17
, pp. 596-603
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
25
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M.A., Hall, A. and Hall, M.N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Rüegg, M.A.5
Hall, A.6
Hall, M.N.7
-
26
-
-
28844434558
-
mTOR-RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R.C. and Mueckler, M. (2005) mTOR-RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406-40416
-
(2005)
J. Biol. Chem
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
27
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long, X., Ortiz-Vega, S., Lin, Y. and Avruch, J. (2005) Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
Avruch, J.4
-
28
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
Findlay, G.M., Yan, L., Procter, J., Mieulet, V. and Lamb, R.F. (2007) A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem. J. 403, 13-20
-
(2007)
Biochem. J
, vol.403
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
29
-
-
42649112409
-
2+/CaM signaling to hVps34
-
2+/CaM signaling to hVps34. Cell Metab. 7, 456-465
-
(2008)
Cell Metab
, vol.7
, pp. 456-465
-
-
Gulati, P.1
Gaspers, L.D.2
Dann, S.G.3
Joaquin, M.4
Nobukuni, T.5
Natt, F.6
Kozma, S.C.7
Thomas, A.P.8
Thomas, G.9
-
30
-
-
44149127993
-
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
-
Juhász, G., Hill, J.H., Yan, Y., Sass, M., Baehrecke, E.H., Backer, J.M. and Neufeld, T.P. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J. Cell Biol. 181, 655-666
-
(2008)
J. Cell Biol
, vol.181
, pp. 655-666
-
-
Juhász, G.1
Hill, J.H.2
Yan, Y.3
Sass, M.4
Baehrecke, E.H.5
Backer, J.M.6
Neufeld, T.P.7
-
31
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak, Y., Peterson, T.R., Shaul, Y.D., Lindquist, R.A., Thoreen, C.C., Bar-Peled, L. and Sabatini, D.M. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
32
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T.P. and Guan, K.L. (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10, 935-945
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
|