메뉴 건너뛰기




Volumn 395, Issue 1-2, 2008, Pages 1-5

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases

Author keywords

Alcohol dehydrogenase; Aldehyde dehydrogenase; Cancer

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; TUMOR MARKER;

EID: 47649089494     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2008.05.001     Document Type: Review
Times cited : (151)

References (50)
  • 2
    • 0002887141 scopus 로고    scopus 로고
    • Alcoholic beverages and cancers of the digestive tract and larynx
    • MacDonald I. (Ed), MPG Books, Bodmin Cornwall
    • Doll R., Forman D., and La Vecchia C. Alcoholic beverages and cancers of the digestive tract and larynx. In: MacDonald I. (Ed). Health Issues Related to Alcohol Consumption. 2nd ed. (1999), MPG Books, Bodmin Cornwall 351-393
    • (1999) Health Issues Related to Alcohol Consumption. 2nd ed. , pp. 351-393
    • Doll, R.1    Forman, D.2    La Vecchia, C.3
  • 4
    • 0348048480 scopus 로고    scopus 로고
    • Pathogenic mechanism of upper aerodigestive tract cancer in alcoholics
    • Seitz H.K., Stickel F., and Homann N. Pathogenic mechanism of upper aerodigestive tract cancer in alcoholics. Int J Cancer 108 (2004) 483-487
    • (2004) Int J Cancer , vol.108 , pp. 483-487
    • Seitz, H.K.1    Stickel, F.2    Homann, N.3
  • 5
    • 0034785672 scopus 로고    scopus 로고
    • Alcohol and upper gastrointestinal tract cancer: the role of local acetaldehyde production
    • Homann N. Alcohol and upper gastrointestinal tract cancer: the role of local acetaldehyde production. Addict Biol 6 (2001) 309-323
    • (2001) Addict Biol , vol.6 , pp. 309-323
    • Homann, N.1
  • 6
    • 0027248652 scopus 로고
    • Induction of cytochrome P450 2E1during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high
    • Badger T.M., Huang J., Ronis M., and Lumpkin C.K. Induction of cytochrome P450 2E1during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem Biophys Res Comm 190 (1993) 780-785
    • (1993) Biochem Biophys Res Comm , vol.190 , pp. 780-785
    • Badger, T.M.1    Huang, J.2    Ronis, M.3    Lumpkin, C.K.4
  • 7
    • 0033665540 scopus 로고    scopus 로고
    • Alcohol and retinoid metabolism
    • Seitz H.K. Alcohol and retinoid metabolism. Gut 47 (2000) 748-750
    • (2000) Gut , vol.47 , pp. 748-750
    • Seitz, H.K.1
  • 8
    • 0029863799 scopus 로고    scopus 로고
    • Kinetic and specificity of human liver aldehyde dehydrogenase toward aliphatic, aromatic, and fused polycyclic aldehydes
    • Klyosov A.A. Kinetic and specificity of human liver aldehyde dehydrogenase toward aliphatic, aromatic, and fused polycyclic aldehydes. Biochemistry 35 (1996) 4457-4467
    • (1996) Biochemistry , vol.35 , pp. 4457-4467
    • Klyosov, A.A.1
  • 9
    • 0026070195 scopus 로고
    • Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects
    • Baraona E., Yokoyama A., Ishii H., et al. Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects. Life Sci 49 (1991) 1929-1934
    • (1991) Life Sci , vol.49 , pp. 1929-1934
    • Baraona, E.1    Yokoyama, A.2    Ishii, H.3
  • 10
    • 0035090650 scopus 로고    scopus 로고
    • Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics
    • Yokoyama A., Muramatsu T., Yokoyama T., et al. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis 22 (2001) 433-439
    • (2001) Carcinogenesis , vol.22 , pp. 433-439
    • Yokoyama, A.1    Muramatsu, T.2    Yokoyama, T.3
  • 11
    • 0028678247 scopus 로고
    • Alcohol dehydrogenases: a family of isozymes with differential functions
    • Holmes R.S. Alcohol dehydrogenases: a family of isozymes with differential functions. Alcohol Alcohol 2 (1994) 127-130
    • (1994) Alcohol Alcohol , vol.2 , pp. 127-130
    • Holmes, R.S.1
  • 12
    • 0033058051 scopus 로고    scopus 로고
    • Distribution of alcohol dehydrogenase isoenzymes in human liver acinus
    • Maly I.P., Toranelli M., and Sasse D. Distribution of alcohol dehydrogenase isoenzymes in human liver acinus. Histochem Cell Biol 111 (1999) 391-397
    • (1999) Histochem Cell Biol , vol.111 , pp. 391-397
    • Maly, I.P.1    Toranelli, M.2    Sasse, D.3
  • 13
    • 0030908953 scopus 로고    scopus 로고
    • Mammalian class II alcohol dehydrogenase. A highly variable enzyme
    • Höög J.O., and Svensson S. Mammalian class II alcohol dehydrogenase. A highly variable enzyme. Adv Exp Med Biol 414 (1997) 303-311
    • (1997) Adv Exp Med Biol , vol.414 , pp. 303-311
    • Höög, J.O.1    Svensson, S.2
  • 14
    • 0024422072 scopus 로고
    • Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase
    • Koivusalo M., Baumann M., and Uotila L. Evidence for the identity of glutathione-dependent formaldehyde dehydrogenase and class III alcohol dehydrogenase. FEBS Lett 257 (1989) 105-109
    • (1989) FEBS Lett , vol.257 , pp. 105-109
    • Koivusalo, M.1    Baumann, M.2    Uotila, L.3
  • 15
    • 0028856593 scopus 로고
    • Upstream structure of human ADH 7 gene and the organ distribution of its expression
    • Yokoyama H., Baraona E., and Lieber C.S. Upstream structure of human ADH 7 gene and the organ distribution of its expression. Biochem Biophys Res Comm 216 (1995) 216-222
    • (1995) Biochem Biophys Res Comm , vol.216 , pp. 216-222
    • Yokoyama, H.1    Baraona, E.2    Lieber, C.S.3
  • 16
    • 0034736060 scopus 로고    scopus 로고
    • Human class V alcohol dehydrogenase (ADH5): a complex transcription unit generates C-terminal multiplicity
    • Strömberg P., and Höög J.O. Human class V alcohol dehydrogenase (ADH5): a complex transcription unit generates C-terminal multiplicity. Biochem Biophys Res Comm 278 (2000) 544-549
    • (2000) Biochem Biophys Res Comm , vol.278 , pp. 544-549
    • Strömberg, P.1    Höög, J.O.2
  • 17
    • 0035969856 scopus 로고    scopus 로고
    • Mammalian alcohol dehydrogenase of higher classes: analyses of human ADH5 and rat ADH6
    • Höög J.O., Brandt M., Hedberg J.J., and Stromberg P. Mammalian alcohol dehydrogenase of higher classes: analyses of human ADH5 and rat ADH6. Chem-Biolog Interact 130 (2001) 395-405
    • (2001) Chem-Biolog Interact , vol.130 , pp. 395-405
    • Höög, J.O.1    Brandt, M.2    Hedberg, J.J.3    Stromberg, P.4
  • 18
    • 0035139107 scopus 로고    scopus 로고
    • Mammalian alcohol dehydrogenases - functional and structural implications
    • Höög J.O., Hedberg J.J., Stromberg P., and Svensson S. Mammalian alcohol dehydrogenases - functional and structural implications. J Biomed Sci 8 (2001) 71-76
    • (2001) J Biomed Sci , vol.8 , pp. 71-76
    • Höög, J.O.1    Hedberg, J.J.2    Stromberg, P.3    Svensson, S.4
  • 19
    • 0032831815 scopus 로고    scopus 로고
    • Interactions of retinoid binding proteins and enzymes in retinoid metabolism
    • Napoli J.L. Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochem Biophys Acta 1440 (1999) 139-162
    • (1999) Biochem Biophys Acta , vol.1440 , pp. 139-162
    • Napoli, J.L.1
  • 20
    • 0031440184 scopus 로고    scopus 로고
    • Enzymology of ethanol and acetaldehyde metabolism in mammals
    • Riveros-Rosas H., Julian-Sanchez A., and Pina E. Enzymology of ethanol and acetaldehyde metabolism in mammals. Arch Med Res 28 (1997) 453-471
    • (1997) Arch Med Res , vol.28 , pp. 453-471
    • Riveros-Rosas, H.1    Julian-Sanchez, A.2    Pina, E.3
  • 21
    • 31644447882 scopus 로고    scopus 로고
    • In vivo contribution of class III alcohol dehydrogenase (ADH3) to alcohol metabolism through activation by cytoplasmic solution hydrophobicity
    • Haseba T., Duester G., Shimizu A., Yamamoto I., Kameyama K., and Ohno Y. In vivo contribution of class III alcohol dehydrogenase (ADH3) to alcohol metabolism through activation by cytoplasmic solution hydrophobicity. Bioch Biophys Acta 1762 (2006) 276-283
    • (2006) Bioch Biophys Acta , vol.1762 , pp. 276-283
    • Haseba, T.1    Duester, G.2    Shimizu, A.3    Yamamoto, I.4    Kameyama, K.5    Ohno, Y.6
  • 22
    • 17744401818 scopus 로고    scopus 로고
    • Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance
    • Yin S.J., Chou C.F., Lai C.L., Lee S.L., and Han C.L. Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance. Chem-Biolog Interact 143 (2003) 219-227
    • (2003) Chem-Biolog Interact , vol.143 , pp. 219-227
    • Yin, S.J.1    Chou, C.F.2    Lai, C.L.3    Lee, S.L.4    Han, C.L.5
  • 24
    • 0031570328 scopus 로고    scopus 로고
    • Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion
    • Steinmetz C.G., Xie P., Weiner H., and Hurley T.D. Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. Structure 5 (1997) 701-711
    • (1997) Structure , vol.5 , pp. 701-711
    • Steinmetz, C.G.1    Xie, P.2    Weiner, H.3    Hurley, T.D.4
  • 25
    • 33646840890 scopus 로고    scopus 로고
    • Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action
    • Wall T.L. Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. Ther Drug Monit 27 (2005) 700-703
    • (2005) Ther Drug Monit , vol.27 , pp. 700-703
    • Wall, T.L.1
  • 26
    • 0027058140 scopus 로고
    • Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase
    • Yoshida A., Hsu L.C., and Davé V. Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. Enzyme 46 (1992) 239-244
    • (1992) Enzyme , vol.46 , pp. 239-244
    • Yoshida, A.1    Hsu, L.C.2    Davé, V.3
  • 27
    • 0026100542 scopus 로고
    • Clinical pharmacokinetics of cyclophosphamide
    • Moore M.J. Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 20 (1991) 194-208
    • (1991) Clin Pharmacokinet , vol.20 , pp. 194-208
    • Moore, M.J.1
  • 28
    • 0032859206 scopus 로고    scopus 로고
    • Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping
    • Vasiliou V., Bairoch A., Tipton K.F., and Nebert D.W. Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. Pharmacogenetics 9 (1999) 421-434
    • (1999) Pharmacogenetics , vol.9 , pp. 421-434
    • Vasiliou, V.1    Bairoch, A.2    Tipton, K.F.3    Nebert, D.W.4
  • 29
    • 0025194121 scopus 로고
    • Alcohol and aldehyde dehydrogenase
    • Ehrig T., Bosron W.F., and Li T.K. Alcohol and aldehyde dehydrogenase. Alcohol Alcohol 25 (1990) 105-116
    • (1990) Alcohol Alcohol , vol.25 , pp. 105-116
    • Ehrig, T.1    Bosron, W.F.2    Li, T.K.3
  • 30
    • 3042551383 scopus 로고
    • Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
    • Vasiliou V., Pappa A., and Estey T. Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism. Drug Met Rev 36 (1994) 279-299
    • (1994) Drug Met Rev , vol.36 , pp. 279-299
    • Vasiliou, V.1    Pappa, A.2    Estey, T.3
  • 31
    • 47649128982 scopus 로고    scopus 로고
    • Jelski W, Zalewski B, Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig Dis Sci in press.
    • Jelski W, Zalewski B, Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig Dis Sci in press.
  • 32
    • 44949242628 scopus 로고    scopus 로고
    • Jelski W, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. J Clin Lab Anal 2008;22:204-9.
    • Jelski W, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. J Clin Lab Anal 2008;22:204-9.
  • 33
    • 3543041839 scopus 로고    scopus 로고
    • The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the colorectal cancer
    • Jelski W., Zalewski B., Chrostek L., and Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the colorectal cancer. Dig Dis Sci 49 (2004) 977-981
    • (2004) Dig Dis Sci , vol.49 , pp. 977-981
    • Jelski, W.1    Zalewski, B.2    Chrostek, L.3    Szmitkowski, M.4
  • 34
    • 38149056496 scopus 로고    scopus 로고
    • The activity of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with colorectal cancer
    • Jelski W., Zalewski B., Chrostek L., and Szmitkowski M. The activity of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with colorectal cancer. Clin Exp Med 7 (2007) 154-157
    • (2007) Clin Exp Med , vol.7 , pp. 154-157
    • Jelski, W.1    Zalewski, B.2    Chrostek, L.3    Szmitkowski, M.4
  • 35
    • 0027428440 scopus 로고
    • Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, ω-hydroxy fatty acids, and retinoids
    • Boleda M.D., Saubi N., Farres J., and Pares X. Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, ω-hydroxy fatty acids, and retinoids. Arch Biochem Biophys 307 (1993) 85-90
    • (1993) Arch Biochem Biophys , vol.307 , pp. 85-90
    • Boleda, M.D.1    Saubi, N.2    Farres, J.3    Pares, X.4
  • 36
    • 33846805973 scopus 로고    scopus 로고
    • The activity of class I, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the gastric cancer
    • Jelski W., Chrostek L., and Szmitkowski M. The activity of class I, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the gastric cancer. Dig Dis Sci 52 (2007) 531-535
    • (2007) Dig Dis Sci , vol.52 , pp. 531-535
    • Jelski, W.1    Chrostek, L.2    Szmitkowski, M.3
  • 37
    • 47649083057 scopus 로고    scopus 로고
    • Jelski W, Kozlowski M, Laudanski J, Niklinski J. Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in esophageal cancer. Dig Dis Sci in press.
    • Jelski W, Kozlowski M, Laudanski J, Niklinski J. Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in esophageal cancer. Dig Dis Sci in press.
  • 38
    • 47649120120 scopus 로고    scopus 로고
    • Jelski W, Chrostek L, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with gastric cancer. Dig Dis Sci in press.
    • Jelski W, Chrostek L, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with gastric cancer. Dig Dis Sci in press.
  • 39
    • 47649119615 scopus 로고    scopus 로고
    • Jelski W, Kozlowski M, Laudanski J, Niklinski J, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with esophageal cancer. Dig Dis Sci in press.
    • Jelski W, Kozlowski M, Laudanski J, Niklinski J, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with esophageal cancer. Dig Dis Sci in press.
  • 40
    • 34447520110 scopus 로고    scopus 로고
    • The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the pancreatic cancer
    • 2007
    • Jelski W., Chrostek L., and Szmitkowski M. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the pancreatic cancer. Pancreas 35 (2007) 142-146 2007
    • (2007) Pancreas , vol.35 , pp. 142-146
    • Jelski, W.1    Chrostek, L.2    Szmitkowski, M.3
  • 41
  • 42
    • 0020455493 scopus 로고
    • Acute effect of ethanol metabolite concentrations of dog pancreas in vivo
    • Guynn R.W., Kuo Y.J., and Shanbour L.L. Acute effect of ethanol metabolite concentrations of dog pancreas in vivo. Alcohol Clin Exp Res 6 (1982) 469-474
    • (1982) Alcohol Clin Exp Res , vol.6 , pp. 469-474
    • Guynn, R.W.1    Kuo, Y.J.2    Shanbour, L.L.3
  • 43
    • 0032192527 scopus 로고    scopus 로고
    • Metabolism of ethanol by rat pancreatic acinar cells
    • Haber P.S., Apte M.V., Applegate T.L., et al. Metabolism of ethanol by rat pancreatic acinar cells. J Lab Clin Med 132 (1998) 294-302
    • (1998) J Lab Clin Med , vol.132 , pp. 294-302
    • Haber, P.S.1    Apte, M.V.2    Applegate, T.L.3
  • 44
    • 0345059397 scopus 로고    scopus 로고
    • Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas
    • Lugea A., Gukovsky I., Gukovskaya A.S., and Pandol S.J. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Gastroenterology 125 (2003) 1845-1859
    • (2003) Gastroenterology , vol.125 , pp. 1845-1859
    • Lugea, A.1    Gukovsky, I.2    Gukovskaya, A.S.3    Pandol, S.J.4
  • 45
    • 47649117061 scopus 로고    scopus 로고
    • Jelski W, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. Dig Dis Sci in press.
    • Jelski W, Zalewski B, Szmitkowski M. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. Dig Dis Sci in press.
  • 46
    • 0025880967 scopus 로고
    • Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
    • De Luca L.M. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J 5 (1991) 2924-2933
    • (1991) FASEB J , vol.5 , pp. 2924-2933
    • De Luca, L.M.1
  • 48
    • 33745699075 scopus 로고    scopus 로고
    • The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the breast cancer
    • Jelski W., Chrostek L., Szmitkowski M., and Markiewicz W. The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the breast cancer. Clin Exp Med 6 (2006) 89-93
    • (2006) Clin Exp Med , vol.6 , pp. 89-93
    • Jelski, W.1    Chrostek, L.2    Szmitkowski, M.3    Markiewicz, W.4
  • 49
    • 0033785030 scopus 로고    scopus 로고
    • A prospective study of the effect on alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk
    • Hines L.M., Hankinson S.E., Smith-Warner S.A., et al. A prospective study of the effect on alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiol Biomarkers Prev 9 (2000) 1099-1105
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 1099-1105
    • Hines, L.M.1    Hankinson, S.E.2    Smith-Warner, S.A.3
  • 50
    • 33744794904 scopus 로고    scopus 로고
    • The activity of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with breast cancer
    • Jelski W., Chrostek L., Markiewicz W., and Szmitkowski M. The activity of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with breast cancer. J Clin Lab Anal 20 (2006) 105-108
    • (2006) J Clin Lab Anal , vol.20 , pp. 105-108
    • Jelski, W.1    Chrostek, L.2    Markiewicz, W.3    Szmitkowski, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.