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Volumn 49, Issue , 2008, Pages 169-194

Fatty acid synthase activity in tumor cells

Author keywords

Cancer; Fatty acid synthase; Lipogenesis

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; FATTY ACID SYNTHASE; PALMITIC ACID;

EID: 58149308842     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4020-8831-5_7     Document Type: Article
Times cited : (37)

References (157)
  • 2
    • 10644239801 scopus 로고    scopus 로고
    • Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
    • Adams, C. M., Reitz, J., De Brabander, J. K., Feramisco, J. D., Li, L., Brown, M. S. and Goldstein, J. L., Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs, J Biol Chem 279 (2004) 52772-52780.
    • (2004) J Biol Chem , vol.279 , pp. 52772-52780
    • Adams, C.M.1    Reitz, J.2    De Brabander, J.K.3    Feramisco, J.D.4    Li, L.5    Brown, M.S.6    Goldstein, J.L.7
  • 3
    • 12444252156 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
    • Alli, P. M., Pinn, M. L., Jaffee, E. M., McFadden, J. M. and Kuhajda, F. P., Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice, Oncogene 24 (2005) 39-46.
    • (2005) Oncogene , vol.24 , pp. 39-46
    • Alli, P.M.1    Pinn, M.L.2    Jaffee, E.M.3    McFadden, J.M.4    Kuhajda, F.P.5
  • 7
    • 0030063936 scopus 로고    scopus 로고
    • Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients
    • Alo, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C. and Di Tondo, U., Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients, Cancer 77 (1996) 474-482.
    • (1996) Cancer , vol.77 , pp. 474-482
    • Alo, P.L.1    Visca, P.2    Marci, A.3    Mangoni, A.4    Botti, C.5    Di Tondo, U.6
  • 10
    • 0024996710 scopus 로고
    • Molecular cloning of the mammalian fatty acid synthase gene and identification of the promoter region
    • Amy, C. M., Williams-Ahlf, B., Naggert, J. and Smith, S., Molecular cloning of the mammalian fatty acid synthase gene and identification of the promoter region, Biochem J 271 (1990) 675-679.
    • (1990) Biochem J , vol.271 , pp. 675-679
    • Amy, C.M.1    Williams-Ahlf, B.2    Naggert, J.3    Smith, S.4
  • 13
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C. and Thompson, C. B., ATP citrate lyase is an important component of cell growth and transformation, Oncogene 24 (2005) 6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 14
    • 34548580317 scopus 로고    scopus 로고
    • Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
    • Beckers, A., Organe, S., Timmermans, L., Scheys, K., Peeters, A., Brusselmans, K., Verhoeven, G. and Swinnen, J. V., Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells, Cancer Res 67 (2007) 8180-8187.
    • (2007) Cancer Res , vol.67 , pp. 8180-8187
    • Beckers, A.1    Organe, S.2    Timmermans, L.3    Scheys, K.4    Peeters, A.5    Brusselmans, K.6    Verhoeven, G.7    Swinnen, J.V.8
  • 17
    • 23044482013 scopus 로고    scopus 로고
    • RNA Interference- Mediated Silencing of the Acetyl-CoA-Carboxylase-(alpha) Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells
    • Brusselmans, K., De Schrijver, E., Verhoeven, G. and Swinnen, J. V., RNA Interference- Mediated Silencing of the Acetyl-CoA-Carboxylase-(alpha) Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells, Cancer Res 65 (2005) 6719-6725.
    • (2005) Cancer Res , vol.65 , pp. 6719-6725
    • Brusselmans, K.1    De Schrijver, E.2    Verhoeven, G.3    Swinnen, J.V.4
  • 18
    • 0019313048 scopus 로고
    • Fatty acid synthesis in the perfused rat lung
    • Buechler, K. F. and Rhoades, R. A., Fatty acid synthesis in the perfused rat lung, Biochim Biophys Acta 619 (1980) 186-195.
    • (1980) Biochim Biophys Acta , vol.619 , pp. 186-195
    • Buechler, K.F.1    Rhoades, R.A.2
  • 20
    • 0037403024 scopus 로고    scopus 로고
    • Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: An interinstitutional study
    • Camassei, F. D., Jenkner, A., Rava, L., Bosman, C., Francalanci, P., Donfrancesco, A., Alo, P. L. and Boldrini, R., Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study, Med Pediatr Oncol 40 (2003b) 302-308.
    • (2003) Med Pediatr Oncol , vol.40 , pp. 302-308
    • Camassei, F.D.1    Jenkner, A.2    Rava, L.3    Bosman, C.4    Francalanci, P.5    Donfrancesco, A.6    Alo, P.L.7    Boldrini, R.8
  • 21
    • 33744808464 scopus 로고    scopus 로고
    • Acetyl-CoA Carboxylase (alpha) Is Essential to Breast Cancer Cell Survival
    • Chajes, V., Cambot, M., Moreau, K., Lenoir, G. M. and Joulin, V., Acetyl-CoA Carboxylase (alpha) Is Essential to Breast Cancer Cell Survival, Cancer Res 66 (2006) 5287-5294.
    • (2006) Cancer Res , vol.66 , pp. 5287-5294
    • Chajes, V.1    Cambot, M.2    Moreau, K.3    Lenoir, G.M.4    Joulin, V.5
  • 24
    • 0023664688 scopus 로고
    • Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells
    • Chalbos, D., Chambon, M., Ailhaud, G. and Rochefort, H., Fatty acid synthetase and its mRNA are induced by progestins in breast cancer cells, J Biol Chem 262 (1987) 9923-9926.
    • (1987) J Biol Chem , vol.262 , pp. 9923-9926
    • Chalbos, D.1    Chambon Ailhaud G., M.2    Rochefort, H.3
  • 25
    • 30844448578 scopus 로고    scopus 로고
    • KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
    • Chang, Y., Wang, J., Lu, X., Thewke, D. P. and Mason, R. J., KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells, J Lipid Res 46 (2005) 2624-2635.
    • (2005) J Lipid Res , vol.46 , pp. 2624-2635
    • Chang, Y.1    Wang, J.2    Lu, X.3    Thewke, D.P.4    Mason, R.J.5
  • 26
    • 0037637624 scopus 로고    scopus 로고
    • Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
    • Chirala, S. S., Chang, H., Matzuk, M., Abu-Elheiga, L., Mao, J., Mahon, K., Finegold, M. and Wakil, S. J., Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero, Proc Natl Acad Sci USA 100 (2003) 6358-6363.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6358-6363
    • Chirala, S.S.1    Chang, H.2    Matzuk, M.3    Abu-Elheiga, L.4    Mao, J.5    Mahon, K.6    Finegold, M.7    Wakil, S.J.8
  • 28
    • 0038418257 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    • De Schrijver, E., Brusselmans, K., Heyns, W., Verhoeven, G. and Swinnen, J. V., RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells, Cancer Res 63 (2003) 3799-3804.
    • (2003) Cancer Res , vol.63 , pp. 3799-3804
    • De Schrijver, E.1    Brusselmans, K.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 29
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • Deberardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S. and Thompson, C. B., Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc Natl Acad Sci USA 104 (2007) 19345-19350.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 31
    • 0028875706 scopus 로고
    • OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate
    • Epstein, J. I., Carmichael, M. and Partin, A. W., OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate, Urology 45 (1995) 81-86.
    • (1995) Urology , vol.45 , pp. 81-86
    • Epstein, J.I.1    Carmichael, M.2    Partin, A.W.3
  • 32
    • 0026783692 scopus 로고
    • Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue.Arole for glucose 6-phosphate
    • Foufelle, F., Gouhot, B., Pegorier, J. P., Perdereau, D., Girard, J. and Ferre, P., Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue.Arole for glucose 6-phosphate, J Biol Chem 267 (1992) 20543-20546.
    • (1992) J Biol Chem , vol.267 , pp. 20543-20546
    • Foufelle, F.1    Gouhot, B.2    Pegorier, J.P.3    Perdereau, D.4    Girard, J.5    Ferre, P.6
  • 33
    • 33847076262 scopus 로고    scopus 로고
    • Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes
    • Freeman, M. R., Cinar, B., Kim, J., Mukhopadhyay, N. K., Di Vizio, D., Adam, R. M. and Solomon, K. R., Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes, Steroids 72 (2007) 210-217.
    • (2007) Steroids , vol.72 , pp. 210-217
    • Freeman, M.R.1    Cinar, B.2    Kim, J.3    Mukhopadhyay, N.K.4    Di Vizio, D.5    Adam, R.M.6    Solomon, K.R.7
  • 34
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • Freeman, M. R., Cinar, B. and Lu, M. L., Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer, Trends Endocrinol Metabol 16 (2005) 273-279.
    • (2005) Trends Endocrinol Metabol , vol.16 , pp. 273-279
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 35
    • 0033104963 scopus 로고    scopus 로고
    • Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats
    • Fukuda, H., Iritani, N., Sugimoto, T. and Ikeda, H., Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats, Eur J Biochem 260 (1999) 505-511.
    • (1999) Eur J Biochem , vol.260 , pp. 505-511
    • Fukuda, H.1    Iritani Sugimoto T., N.2    Ikeda, H.3
  • 37
    • 0031427126 scopus 로고    scopus 로고
    • Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis
    • Furuya, Y., Akimoto, S., Yasuda, K. and Ito, H., Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis, Anticancer Res 17 (1997) 4589-4593.
    • (1997) Anticancer Res , vol.17 , pp. 4589-4593
    • Furuya, Y.1    Akimoto Yasuda K., S.2    Ito, H.3
  • 38
    • 0035133059 scopus 로고    scopus 로고
    • Increased fatty acid synthase is a therapeutic target in mesothelioma
    • Gabrielson, E. W., Pinn, M. L., Testa, J. R. and Kuhajda, F. P., Increased fatty acid synthase is a therapeutic target in mesothelioma, Clin Cancer Res 7 (2001) 153-157.
    • (2001) Clin Cancer Res , vol.7 , pp. 153-157
    • Gabrielson, E.W.1    Pinn, M.L.2    Testa, J.R.3    Kuhajda, F.P.4
  • 39
    • 0031007392 scopus 로고    scopus 로고
    • Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
    • Gansler, T. S., Hardman, W., 3rd, Hunt, D. A., Schaffel, S. and Hennigar, R. A., Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival, Hum Pathol 28 (1997) 686-692.
    • (1997) Hum Pathol , vol.28 , pp. 686-692
    • Gansler, T.S.1    Hardman, W.2    Hunt, D.A.3    Schaffel, S.4    Hennigar, R.A.5
  • 40
    • 33751179018 scopus 로고    scopus 로고
    • Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma
    • Gao, Y., Lin, L. P., Zhu, C. H., Chen, Y., Hou, Y. T. and Ding, J., Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma, Cancer Biol Ther 5 (2006) 978-985.
    • (2006) Cancer Biol Ther , vol.5 , pp. 978-985
    • Gao, Y.1    Lin, L.P.2    Zhu, C.H.3    Chen, Y.4    Hou, Y.T.5    Ding, J.6
  • 44
    • 0034791515 scopus 로고    scopus 로고
    • Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory elementbinding protein pathway
    • Heemers, H., Maes, B., Foufelle, F., Heyns, W., Verhoeven, G. and Swinnen, J. V., Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory elementbinding protein pathway, Mol Endocrinol 15 (2001) 1817-1828.
    • (2001) Mol Endocrinol , vol.15 , pp. 1817-1828
    • Heemers, H.1    Maes, B.2    Foufelle, F.3    Heyns, W.4    Verhoeven, G.5    Swinnen, J.V.6
  • 47
    • 0036733979 scopus 로고    scopus 로고
    • Key role of mitochondria in ceruleninmediated apoptosis
    • Heiligtag, S. J., Bredehorst, R. and David, K. A., Key role of mitochondria in ceruleninmediated apoptosis, Cell Death Differ 9 (2002) 1017-1025.
    • (2002) Cell Death Differ , vol.9 , pp. 1017-1025
    • Heiligtag, S.J.1    Bredehorst, R.2    David, K.A.3
  • 49
    • 0028855519 scopus 로고
    • Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis
    • Hillgartner, F. B., Salati, L. M. and Goodridge, A. G., Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis, Physiol Rev 75 (1995) 47-76.
    • (1995) Physiol Rev , vol.75 , pp. 47-76
    • Hillgartner, F.B.1    Salati, L.M.2    Goodridge, A.G.3
  • 50
    • 35248870232 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspasedependent apoptosis in human melanoma A-375 cells
    • Ho, T. S., Ho, Y. P., Wong, W. Y., Chi-Ming Chiu, L., Wong, Y. S. and Eng-Choon Ooi, V., Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspasedependent apoptosis in human melanoma A-375 cells, Biomed Pharmacother 61 (2007) 578-587.
    • (2007) Biomed Pharmacother , vol.61 , pp. 578-587
    • Ho, T.S.1    Ho, Y.P.2    Wong, W.Y.3    Chi-Ming Chiu, L.4    Wong, Y.S.5    Eng-Choon Ooi, V.6
  • 52
    • 0028146621 scopus 로고
    • Coordination of membrane phospholipid synthesis with the cell cycle
    • Jackowski, S., Coordination of membrane phospholipid synthesis with the cell cycle, J Biol Chem 269 (1994) 3858-3867.
    • (1994) J Biol Chem , vol.269 , pp. 3858-3867
    • Jackowski, S.1
  • 53
    • 33646018341 scopus 로고    scopus 로고
    • Fatty acid elongases in mammals: Their regulation and roles in metabolism
    • Jakobsson, A., Westerberg, R. and Jacobsson, A., Fatty acid elongases in mammals: their regulation and roles in metabolism, Prog Lipid Res 45 (2006) 237-249.
    • (2006) Prog Lipid Res , vol.45 , pp. 237-249
    • Jakobsson Westerberg R., A.1    Jacobsson, A.2
  • 55
    • 0029346969 scopus 로고
    • The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer
    • Jensen, V., Ladekarl, M., Holm-Nielsen, P., Melsen, F. and Soerensen, F. B., The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer, J Pathol 176 (1995) 343-352.
    • (1995) J Pathol , vol.176 , pp. 343-352
    • Jensen, V.1    Ladekarl, M.2    Holm-Nielsen, P.3    Melsen, F.4    Soerensen, F.B.5
  • 56
    • 35748952524 scopus 로고    scopus 로고
    • Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion
    • Joseph, J. W., Odegaard, M. L., Ronnebaum, S. M., Burgess, S. C., Muehlbauer, J., Sherry, A. D. and Newgard, C. B., Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion, J Biol Chem 282 (2007) 31592-31600.
    • (2007) J Biol Chem , vol.282 , pp. 31592-31600
    • Joseph, J.W.1    Odegaard, M.L.2    Ronnebaum, S.M.3    Burgess, S.C.4    Muehlbauer, J.5    Sherry, A.D.6    Newgard, C.B.7
  • 57
    • 0028214097 scopus 로고
    • Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids
    • Jump, D. B., Clarke, S. D., Thelen, A. and Liimatta, M., Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids, J Lipid Res 35 (1994) 1076-1084.
    • (1994) J Lipid Res , vol.35 , pp. 1076-1084
    • Jump, D.B.1    Clarke, S.D.2    Thelen, A.3    Liimatta, M.4
  • 58
    • 24044480642 scopus 로고    scopus 로고
    • Fatty acid synthase expression in cutaneous melanocytic neoplasms
    • Kapur, P., Rakheja, D., Roy, L. C. and Hoang, M. P., Fatty acid synthase expression in cutaneous melanocytic neoplasms, Mod Pathol 18 (2005) 1107-1112.
    • (2005) Mod Pathol , vol.18 , pp. 1107-1112
    • Kapur, P.1    Rakheja, D.2    Roy, L.C.3    Hoang, M.P.4
  • 59
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B. and Wahli, W., Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting, J Clin Invest 103 (1999) 1489-1498.
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 60
    • 3142713030 scopus 로고    scopus 로고
    • A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
    • Knowles, L. M., Axelrod, F., Browne, C. D. and Smith, J. W., A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2, J Biol Chem 279 (2004) 30540-30545.
    • (2004) J Biol Chem , vol.279 , pp. 30540-30545
    • Knowles, L.M.1    Axelrod, F.2    Browne, C.D.3    Smith, J.W.4
  • 61
    • 1542720382 scopus 로고    scopus 로고
    • Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    • Kridel, S. J., Axelrod, F., Rozenkrantz, N. and Smith, J. W., Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity, Cancer Res 64 (2004) 2070-2075.
    • (2004) Cancer Res , vol.64 , pp. 2070-2075
    • Kridel, S.J.1    Axelrod, F.2    Rozenkrantz, N.3    Smith, J.W.4
  • 62
    • 36048956529 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors: New directions for oncology
    • Kridel, S. J., Lowther, W. T. and Pemble, C. W., Fatty acid synthase inhibitors: new directions for oncology, Expert Opin Investig Drugs 16 (2007) 1817-1829.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1817-1829
    • Kridel, S.J.1    Lowther, W.T.2    Pemble, C.W.3
  • 63
    • 0034002793 scopus 로고    scopus 로고
    • Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
    • Kuhajda, F. P., Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology, Nutrition 16 (2000) 202-208.
    • (2000) Nutrition , vol.16 , pp. 202-208
    • Kuhajda, F.P.1
  • 64
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • Kuhajda, F. P., Fatty acid synthase and cancer: new application of an old pathway, Cancer Res 66 (2006) 5977-5980.
    • (2006) Cancer Res , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 66
    • 2642689204 scopus 로고
    • Expression of haptoglobin-related protein and its potential role as a tumor antigen
    • Kuhajda, F. P., Katumuluwa, A. I. and Pasternack, G. R., Expression of haptoglobin-related protein and its potential role as a tumor antigen, Proc Natl Acad Sci USA 86 (1989a) 1188-1192.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1188-1192
    • Kuhajda, F.P.1    Katumuluwa, A.I.2    Pasternack, G.R.3
  • 67
    • 0024453198 scopus 로고
    • Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease
    • Kuhajda, F. P., Piantadosi, S. and Pasternack, G. R., Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease, N Engl J Med 321 (1989b) 636-641.
    • (1989) N Engl J Med , vol.321 , pp. 636-641
    • Kuhajda, F.P.1    Piantadosi, S.2    Pasternack, G.R.3
  • 69
    • 0037226462 scopus 로고    scopus 로고
    • Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis
    • Kumar-Sinha, C., Ignatoski, K. W., Lippman, M. E., Ethier, S. P. and Chinnaiyan, A. M., Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis, Cancer Res 63 (2003) 132-139.
    • (2003) Cancer Res , vol.63 , pp. 132-139
    • Kumar-Sinha, C.1    Ignatoski, K.W.2    Lippman, M.E.3    Ethier, S.P.4    Chinnaiyan, A.M.5
  • 70
    • 0034011584 scopus 로고    scopus 로고
    • Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells
    • Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T. and Suzuki, T., Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells, J Histochem Cytochem 48 (2000) 613-622.
    • (2000) J Histochem Cytochem , vol.48 , pp. 613-622
    • Kusakabe, T.1    Maeda, M.2    Hoshi, N.3    Sugino, T.4    Watanabe Fukuda T., K.5    Suzuki, T.6
  • 71
    • 0036151105 scopus 로고    scopus 로고
    • Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach
    • Kusakabe, T., Nashimoto, A., Honma, K. and Suzuki, T., Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach, Histopathology 40 (2002) 71-79.
    • (2002) Histopathology , vol.40 , pp. 71-79
    • Kusakabe, T.1    Nashimoto Honma K., A.2    Suzuki, T.3
  • 73
    • 0035866378 scopus 로고    scopus 로고
    • Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53
    • Li, J.N.,Gorospe, M.,Chrest, F. J.,Kumaravel, T. S., Evans,M. K.,Han,W.F. and Pizer,E. S., Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53, Cancer Res 61 (2001) 1493-1499.
    • (2001) Cancer Res , vol.61 , pp. 1493-1499
    • Li, J.N.1    Gorospe, M.2    Chrest, F.J.3    Kumaravel, T.S.4    Evans, M.K.5    Han, W.F.6    Pizer, E.S.7
  • 74
    • 33847034466 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
    • Little, J. L., Wheeler, F. B., Fels, D. R., Koumenis, C. and Kridel, S. J., Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells, Cancer Res 67 (2007) 1262-1269.
    • (2007) Cancer Res , vol.67 , pp. 1262-1269
    • Little, J.L.1    Wheeler, F.B.2    Fels, D.R.3    Koumenis, C.4    Kridel, S.J.5
  • 75
    • 33645462548 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/ Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis
    • Liu, X., Shi, Y., Giranda, V. L. and Luo, Y., Inhibition of the phosphatidylinositol 3-kinase/ Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis, Mol Cancer Ther 5 (2006) 494-501.
    • (2006) Mol Cancer Ther , vol.5 , pp. 494-501
    • Liu, X.1    Shi, Y.2    Giranda, V.L.3    Luo, Y.4
  • 77
    • 12644314084 scopus 로고    scopus 로고
    • Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
    • Magana, M. M. and Osborne, T. F., Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter, J Biol Chem 271 (1996) 32689-32694.
    • (1996) J Biol Chem , vol.271 , pp. 32689-32694
    • Magana, M.M.1    Osborne, T.F.2
  • 78
    • 33644697200 scopus 로고    scopus 로고
    • Architecture of mammalian fatty acid synthase at 4.5 A resolution
    • Maier, T., Jenni, S. and Ban, N., Architecture of mammalian fatty acid synthase at 4.5 A resolution, Science 311 (2006) 1258-1262.
    • (2006) Science , vol.311 , pp. 1258-1262
    • Maier Jenni S., T.1    Ban, N.2
  • 80
    • 22344436414 scopus 로고    scopus 로고
    • The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival
    • Menendez, J. A., Oza, B. P., Colomer, R. and Lupu, R., The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival, Int J Oncol 26 (2005a) 1507-1515.
    • (2005) Int J Oncol , vol.26 , pp. 1507-1515
    • Menendez, J.A.1    Oza, B.P.2    Colomer, R.3    Lupu, R.4
  • 81
    • 23044480300 scopus 로고    scopus 로고
    • Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
    • Menendez, J. A., Vellon, L. and Lupu, R., Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene, Ann Oncol 16 (2005b) 1253-1267.
    • (2005) Ann Oncol , vol.16 , pp. 1253-1267
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 82
    • 3242685815 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
    • Menendez, J. A., Vellon, L., Mehmi, I., Oza, B. P., Ropero, S., Colomer, R. and Lupu, R., Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells, Proc Natl Acad Sci USA 101 (2004) 10715-10720.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10715-10720
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3    Oza, B.P.4    Ropero, S.5    Colomer, R.6    Lupu, R.7
  • 83
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum, L. Z., Witters, L. A., Pasternack, G. R. and Kuhajda, F. P., Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma, Clin Cancer Res 3 (1997) 2115-2120.
    • (1997) Clin Cancer Res , vol.3 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 84
    • 0036245227 scopus 로고    scopus 로고
    • Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
    • Moon, Y. S., Latasa, M. J., Griffin, M. J. and Sul, H. S., Suppression of fatty acid synthase promoter by polyunsaturated fatty acids, J Lipid Res 43 (2002) 691-698.
    • (2002) J Lipid Res , vol.43 , pp. 691-698
    • Moon, Y.S.1    Latasa, M.J.2    Griffin, M.J.3    Sul, H.S.4
  • 86
    • 0027936018 scopus 로고
    • Identification of an insulin response element in the fatty acid synthase promoter
    • Moustaid, N., Beyer, R. S. and Sul, H. S., Identification of an insulin response element in the fatty acid synthase promoter, J Biol Chem 269 (1994) 5629-5634.
    • (1994) J Biol Chem , vol.269 , pp. 5629-5634
    • Moustaid, N.1    Beyer, R.S.2    Sul, H.S.3
  • 87
    • 0025998802 scopus 로고
    • Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine
    • Moustaid, N. and Sul, H. S., Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine, J Biol Chem 266 (1991) 18550-18554.
    • (1991) J Biol Chem , vol.266 , pp. 18550-18554
    • Moustaid, N.1    Sul, H.S.2
  • 88
    • 30944461586 scopus 로고    scopus 로고
    • PTEN and GSK3beta: Key regulators of progression to androgen-independent prostate cancer
    • Mulholland, D. J., Dedhar, S., Wu, H. and Nelson, C. C., PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer, Oncogene 25 (2006) 329-337.
    • (2006) Oncogene , vol.25 , pp. 329-337
    • Mulholland, D.J.1    Dedhar, S.2    Wu, H.3    Nelson, C.C.4
  • 89
    • 0035131412 scopus 로고    scopus 로고
    • Fatty acid synthase: An early molecular marker of progression of prostatic adenocarcinoma to androgen independence
    • Myers, R. B., Oelschlager, D. K., Weiss, H. L., Frost, A. R. and Grizzle, W. E., Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence, J Urol 165 (2001) 1027-1032.
    • (2001) J Urol , vol.165 , pp. 1027-1032
    • Myers, R.B.1    Oelschlager, D.K.2    Weiss, H.L.3    Frost, A.R.4    Grizzle, W.E.5
  • 90
    • 0035789570 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma
    • Nemoto, T., Terashima, S., Kogure, M., Hoshino, Y., Kusakabe, T., Suzuki, T. and Gotoh, M., Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma, Pathobiology 69 (2001) 297-303.
    • (2001) Pathobiology , vol.69 , pp. 297-303
    • Nemoto, T.1    Terashima, S.2    Kogure, M.3    Hoshino, Y.4    Kusakabe Suzuki T., T.5    Gotoh, M.6
  • 91
    • 32844456752 scopus 로고    scopus 로고
    • Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component
    • Ogino, S., Brahmandam, M., Cantor, M., Namgyal, C., Kawasaki, T., Kirkner, G., Meyerhardt, J. A., Loda, M. and Fuchs, C. S., Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component, Mod Pathol 19 (2006) 59-68.
    • (2006) Mod Pathol , vol.19 , pp. 59-68
    • Ogino, S.1    Brahmandam, M.2    Cantor, M.3    Namgyal, C.4    Kawasaki, T.5    Kirkner, G.6    Meyerhardt, J.A.7    Loda, M.8    Fuchs, C.S.9
  • 92
    • 34248170638 scopus 로고    scopus 로고
    • Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    • Ogino, S., Kawasaki, T., Ogawa, A., Kirkner, G. J., Loda, M. and Fuchs, C. S., Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype, Hum Pathol 38 (2007) 842-849.
    • (2007) Hum Pathol , vol.38 , pp. 842-849
    • Ogino, S.1    Kawasaki, T.2    Ogawa, A.3    Kirkner, G.J.4    Loda, M.5    Fuchs, C.S.6
  • 93
    • 0021466891 scopus 로고
    • Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
    • Ookhtens, M., Kannan, R., Lyon, I. and Baker, N., Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor, Am J Physiol Regul Integr Comp Physiol 247 (1984) R146-R153.
    • (1984) Am J Physiol Regul Integr Comp Physiol , vol.247 , pp. R146-R153
    • Ookhtens, M.1    Kannan Lyon I., R.2    Baker, N.3
  • 96
    • 0142106795 scopus 로고    scopus 로고
    • Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
    • Pflug, B. R., Pecher, S. M., Brink, A. W., Nelson, J. B. and Foster, B. A., Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model, Prostate 57 (2003) 245-254.
    • (2003) Prostate , vol.57 , pp. 245-254
    • Pflug, B.R.1    Pecher, S.M.2    Brink, A.W.3    Nelson, J.B.4    Foster, B.A.5
  • 97
    • 0032532655 scopus 로고    scopus 로고
    • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    • Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A. and Han, W. F., Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines, Cancer Res 58 (1998a) 4611-4615.
    • (1998) Cancer Res , vol.58 , pp. 4611-4615
    • Pizer, E.S.1    Chrest, F.J.2    DiGiuseppe, J.A.3    Han, W.F.4
  • 98
    • 0029949512 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
    • Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E. and Kuhajda, F. P., Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells, Cancer Res 56 (1996a) 2745-2747.
    • (1996) Cancer Res , vol.56 , pp. 2745-2747
    • Pizer, E.S.1    Jackisch, C.2    Wood, F.D.3    Pasternack, G.R.4    Davidson, N.E.5    Kuhajda, F.P.6
  • 99
    • 0030965924 scopus 로고    scopus 로고
    • Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium
    • Pizer, E. S., Kurman, R. J., Pasternack, G. R. and Kuhajda, F. P., Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium, Int J Gynecol Pathol 16 (1997) 45-51.
    • (1997) Int J Gynecol Pathol , vol.16 , pp. 45-51
    • Pizer, E.S.1    Kurman, R.J.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 100
    • 0032147199 scopus 로고    scopus 로고
    • Fatty acid synthase expression in endometrial carcinoma: Correlation with cell proliferation and hormone receptors
    • Pizer, E. S., Lax, S. F., Kuhajda, F. P., Pasternack, G. R. and Kurman, R. J., Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors, Cancer 83 (1998b) 528-537.
    • (1998) Cancer , vol.83 , pp. 528-537
    • Pizer, E.S.1    Lax, S.F.2    Kuhajda, F.P.3    Pasternack, G.R.4    Kurman, R.J.5
  • 101
    • 0035341888 scopus 로고    scopus 로고
    • Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression
    • Pizer, E. S., Pflug, B. R., Bova, G. S., Han, W. F., Udan, M. S. and Nelson, J. B., Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression, Prostate 47 (2001) 102-110.
    • (2001) Prostate , vol.47 , pp. 102-110
    • Pizer, E.S.1    Pflug, B.R.2    Bova, G.S.3    Han, W.F.4    Udan, M.S.5    Nelson, J.B.6
  • 102
    • 0034650757 scopus 로고    scopus 로고
    • Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer, E.S., Thupari, J.,Han,W. F., Pinn,M. L.,Chrest, F. J., Frehywot,G. L., Townsend, C. A. and Kuhajda, F. P., Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts, Cancer Res 60 (2000) 213-218.
    • (2000) Cancer Res , vol.60 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3    Pinn, M.L.4    Chrest, F.J.5    Frehywot, G.L.6    Townsend, C.A.7    Kuhajda, F.P.8
  • 103
    • 0029971427 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
    • Pizer, E. S.,Wood, F.D.,Heine, H. S.,Romantsev, F. E., Pasternack, G.R. andKuhajda, F. P., Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer, Cancer Res 56 (1996b) 1189-1193.
    • (1996) Cancer Res , vol.56 , pp. 1189-1193
    • Pizer, E.S.1    Wood, F.D.2    Heine, H.S.3    Romantsev, F.E.4    Pasternack, G.R.5    Kuhajda, F.P.6
  • 104
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann, T., Griffiths, B., Chung, Y. L., Delpuech, O., Griffiths, J. R., Downward, J. and Schulze, A., PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP, Oncogene 24 (2005) 6465-6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.L.3    Delpuech, O.4    Griffiths, J.R.5    Downward, J.6    Schulze, A.7
  • 105
    • 0032567344 scopus 로고    scopus 로고
    • Fatty acid synthase dimers containing catalytically active beta-ketoacyl synthase or malonyl/acetyltransferase domains in only one subunit can support fatty acid synthesis at the acyl carrier protein domains of both subunits
    • Rangan, V. S., Joshi, A. K. and Smith, S., Fatty acid synthase dimers containing catalytically active beta-ketoacyl synthase or malonyl/acetyltransferase domains in only one subunit can support fatty acid synthesis at the acyl carrier protein domains of both subunits, J Biol Chem 273 (1998) 34949-34953.
    • (1998) J Biol Chem , vol.273 , pp. 34949-34953
    • Rangan, V.S.1    Joshi, A.K.2    Smith, S.3
  • 106
    • 0035845638 scopus 로고    scopus 로고
    • Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro
    • Rangan, V. S., Joshi, A. K. and Smith, S., Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro, Biochemistry 40 (2001) 10792-10799.
    • (2001) Biochemistry , vol.40 , pp. 10792-10799
    • Rangan, V.S.1    Joshi, A.K.2    Smith, S.3
  • 107
    • 0030026643 scopus 로고    scopus 로고
    • Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP
    • Rangan, V. S., Oskouian, B. and Smith, S., Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP, J Biol Chem 271 (1996) 2307-2312.
    • (1996) J Biol Chem , vol.271 , pp. 2307-2312
    • Rangan, V.S.1    Oskouian, B.2    Smith, S.3
  • 109
    • 33750266831 scopus 로고    scopus 로고
    • Trafficking and signaling by fatty-acylated and prenylated proteins
    • Resh, M. D., Trafficking and signaling by fatty-acylated and prenylated proteins, Nat Chem Biol 2 (2006) 584-590.
    • (2006) Nat Chem Biol , vol.2 , pp. 584-590
    • Resh, M.D.1
  • 111
    • 0035877604 scopus 로고    scopus 로고
    • Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription
    • Rufo, C., Teran-Garcia, M., Nakamura, M. T., Koo, S. H., Towle, H. C. and Clarke, S. D., Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription, J Biol Chem 276 (2001) 21969-21975.
    • (2001) J Biol Chem , vol.276 , pp. 21969-21975
    • Rufo, C.1    Teran-Garcia, M.2    Nakamura, M.T.3    Koo, S.H.4    Towle, H.C.5    Clarke, S.D.6
  • 112
    • 0014076991 scopus 로고
    • Control of lipid metabolism in hepatomas: Insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control
    • Sabine, J. R., Abraham, S. and Chaikoff, I. L., Control of lipid metabolism in hepatomas: insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control, Cancer Res 27 (1967) 793-799.
    • (1967) Cancer Res , vol.27 , pp. 793-799
    • Sabine, J.R.1    Abraham, S.2    Chaikoff, I.L.3
  • 113
    • 0032489460 scopus 로고    scopus 로고
    • S., Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavageactivating Protein
    • Sakai, J., Nohturfft, A., Goldstein, J. L. and Brown, M. S., Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavageactivating Protein. Evidence from in vivo competition studies, J Biol Chem 273 (1998) 5785-5793.
    • (1998) Evidence from in vivo competition studies, J Biol Chem , vol.273 , pp. 5785-5793
    • Sakai, J.1    Nohturfft, A.2    Goldstein, J.L.3    Brown, M.4
  • 114
    • 30944435119 scopus 로고    scopus 로고
    • The fate and intermediary metabolism of stearic acid
    • Sampath, H. and Ntambi, J. M., The fate and intermediary metabolism of stearic acid, Lipids 40 (2005) 1187-1191.
    • (2005) Lipids , vol.40 , pp. 1187-1191
    • Sampath, H.1    Ntambi, J.M.2
  • 116
  • 117
    • 0029829119 scopus 로고    scopus 로고
    • Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer
    • Shurbaji, M. S., Kalbfleisch, J. H. and Thurmond, T. S., Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer, Hum Pathol 27 (1996) 917-921.
    • (1996) Hum Pathol , vol.27 , pp. 917-921
    • Shurbaji, M.S.1    Kalbfleisch, J.H.2    Thurmond, T.S.3
  • 118
    • 0026649789 scopus 로고
    • Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator
    • Shurbaji, M. S., Kuhajda, F. P., Pasternack, G. R. and Thurmond, T. S., Expression of oncogenic antigen 519 (OA-519) in prostate cancer is a potential prognostic indicator, Am J Clin Pathol 97 (1992) 686-691.
    • (1992) Am J Clin Pathol , vol.97 , pp. 686-691
    • Shurbaji, M.S.1    Kuhajda, F.P.2    Pasternack, G.R.3    Thurmond, T.S.4
  • 119
    • 42949097680 scopus 로고    scopus 로고
    • ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes
    • Silva, S. D., Perez, D. E., Alves, F. A., Nishimoto, I. N., Pinto, C. A. L., Kowalski, L. P. and Graner, E., ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes, Oral Oncol 44(5) (2008) 484-490.
    • (2008) Oral Oncol , vol.44 , Issue.2008 , pp. 484-490
    • Silva, S.D.1    Perez, D.E.2    Alves, F.A.3    Nishimoto, I.N.4    Pinto, C.A.L.5    Kowalski, L.P.6    Graner, E.7
  • 120
    • 33644687879 scopus 로고    scopus 로고
    • Architectural options for a fatty acid synthase
    • Smith, S., Architectural options for a fatty acid synthase, Science 311 (2006) 1251-1252.
    • (2006) Science , vol.311 , pp. 1251-1252
    • Smith, S.1
  • 121
    • 0037411269 scopus 로고    scopus 로고
    • Structural and functional organization of the animal fatty acid synthase
    • Smith, S., Witkowski, A. and Joshi, A. K., Structural and functional organization of the animal fatty acid synthase, Prog Lipid Res 42 (2003) 289-317.
    • (2003) Prog Lipid Res , vol.42 , pp. 289-317
    • Smith, S.1    Witkowski, A.2    Joshi, A.K.3
  • 123
    • 0030936232 scopus 로고    scopus 로고
    • Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP
    • Swinnen, J. V., Esquenet, M., Goossens, K., Heyns, W. and Verhoeven, G., Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP, Cancer Res 57 (1997a) 1086-1090.
    • (1997) Cancer Res , vol.57 , pp. 1086-1090
    • Swinnen, J.V.1    Esquenet, M.2    Goossens, K.3    Heyns, W.4    Verhoeven, G.5
  • 124
    • 0034718771 scopus 로고    scopus 로고
    • Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
    • Swinnen, J. V., Heemers, H., Deboel, L., Foufelle, F., Heyns, W. and Verhoeven, G., Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway, Oncogene 19 (2000a) 5173-5181.
    • (2000) Oncogene , vol.19 , pp. 5173-5181
    • Swinnen, J.V.1    Heemers, H.2    Deboel, L.3    Foufelle, F.4    Heyns, W.5    Verhoeven, G.6
  • 125
    • 0036497907 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    • Swinnen, J. V., Roskams, T., Joniau, S., Van Poppel, H., Oyen, R., Baert, L., Heyns, W. and Verhoeven, G., Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer, Int J Cancer 98 (2002) 19-22.
    • (2002) Int J Cancer , vol.98 , pp. 19-22
    • Swinnen, J.V.1    Roskams, T.2    Joniau, S.3    Van Poppel, H.4    Oyen, R.5    Baert, L.6    Heyns, W.7    Verhoeven, G.8
  • 126
    • 0030666828 scopus 로고    scopus 로고
    • Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins
    • Swinnen, J. V., Ulrix, W., Heyns, W. and Verhoeven, G., Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins, Proc Natl Acad Sci USA 94 (1997b) 12975-12980.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12975-12980
    • Swinnen, J.V.1    Ulrix, W.2    Heyns, W.3    Verhoeven, G.4
  • 129
    • 0018769394 scopus 로고
    • Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast
    • Szutowicz, A., Kwiatkowski, J. and Angielski, S., Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast, Br J Cancer 39 (1979) 681-687.
    • (1979) Br J Cancer , vol.39 , pp. 681-687
    • Szutowicz Kwiatkowski J., A.1    Angielski, S.2
  • 130
    • 0038176163 scopus 로고    scopus 로고
    • Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas
    • Takahiro, T., Shinichi, K. and Toshimitsu, S., Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas, Clin Cancer Res 9 (2003) 2204-2212.
    • (2003) Clin Cancer Res , vol.9 , pp. 2204-2212
    • Takahiro Shinichi K., T.1    Toshimitsu, S.2
  • 131
    • 33947261702 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): Evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c
    • Teran-Garcia, M., Adamson, A. W., Yu, G., Rufo, C., Suchankova, G., Dreesen, T. D., Tekle, M., Clarke, S. D. and Gettys, T. W., Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c, Biochem J 402 (2007) 591-600.
    • (2007) Biochem J , vol.402 , pp. 591-600
    • Teran-Garcia, M.1    Adamson, A.W.2    Yu, G.3    Rufo, C.4    Suchankova, G.5    Dreesen, T.D.6    Tekle, M.7    Clarke, S.D.8    Gettys, T.W.9
  • 132
    • 0021924147 scopus 로고
    • Biosynthesis of fatty acids by lactating human breast epithelial cells: An evaluation of the contribution to the overall composition of human milk fat
    • Thompson, B. J. and Smith, S., Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat, Pediatr Res 19 (1985) 139-143.
    • (1985) Pediatr Res , vol.19 , pp. 139-143
    • Thompson, B.J.1    Smith, S.2
  • 133
    • 3042781707 scopus 로고    scopus 로고
    • Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass
    • Thupari, J. N., Kim, E. K., Moran, T. H., Ronnett, G. V. and Kuhajda, F. P., Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass, Am J Physiol Endocrinol Metab 287 (2004) E97-E104.
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. E97-E104
    • Thupari, J.N.1    Kim, E.K.2    Moran, T.H.3    Ronnett, G.V.4    Kuhajda, F.P.5
  • 134
    • 0037047112 scopus 로고    scopus 로고
    • C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
    • Thupari, J. N., Landree, L. E., Ronnett, G. V. and Kuhajda, F. P., C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity, Proc Natl Acad Sci USA 99 (2002) 9498-9502.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9498-9502
    • Thupari, J.N.1    Landree, L.E.2    Ronnett, G.V.3    Kuhajda, F.P.4
  • 135
    • 33646012970 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase by polyphenols
    • Tian, W. X., Inhibition of fatty acid synthase by polyphenols, Curr Med Chem 13 (2006) 967-977.
    • (2006) Curr Med Chem , vol.13 , pp. 967-977
    • Tian, W.X.1
  • 136
    • 11144228934 scopus 로고    scopus 로고
    • C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure
    • Tu, Y., Thupari, J. N., Kim, E. K., Pinn, M. L., Moran, T. H., Ronnett, G. V. and Kuhajda, F. P., C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure, Endocrinology 146 (2005) 486-493.
    • (2005) Endocrinology , vol.146 , pp. 486-493
    • Tu, Y.1    Thupari, J.N.2    Kim, E.K.3    Pinn, M.L.4    Moran, T.H.5    Ronnett, G.V.6    Kuhajda, F.P.7
  • 138
    • 0036469122 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 30-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    • Van de Sande, T., De Schrijver, E., Heyns, W., Verhoeven, G. and Swinnen, J. V., Role of the phosphatidylinositol 30-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells, Cancer Res 62 (2002) 642-646.
    • (2002) Cancer Res , vol.62 , pp. 642-646
    • Van de Sande, T.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 139
    • 19944398464 scopus 로고    scopus 로고
    • High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
    • Van de Sande, T., Roskams, T., Lerut, E., Joniau, S., Van Poppel, H., Verhoeven, G. and Swinnen, J. V., High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB, J Pathol 206 (2005) 214-219.
    • (2005) J Pathol , vol.206 , pp. 214-219
    • Van de Sande, T.1    Roskams, T.2    Lerut, E.3    Joniau, S.4    Van Poppel, H.5    Verhoeven, G.6    Swinnen, J.V.7
  • 142
    • 0016605028 scopus 로고
    • Hormonal regulation of fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver
    • Volpe, J. J. and Marasa, J. C., Hormonal regulation of fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver, Biochim Biophys Acta 380 (1975) 454-472.
    • (1975) Biochim Biophys Acta , vol.380 , pp. 454-472
    • Volpe, J.J.1    Marasa, J.C.2
  • 143
    • 0024315871 scopus 로고
    • Fatty acid synthase, a proficient multifunctional enzyme
    • Wakil, S. J., Fatty acid synthase, a proficient multifunctional enzyme, Biochemistry 28 (1989) 4523-4530.
    • (1989) Biochemistry , vol.28 , pp. 4523-4530
    • Wakil, S.J.1
  • 144
    • 0020643469 scopus 로고
    • Fatty acid synthesis and its regulation
    • Wakil, S. J., Stoops, J. K. and Joshi, V. C., Fatty acid synthesis and its regulation, Annu Rev Biochem 52 (1983) 537-579.
    • (1983) Annu Rev Biochem , vol.52 , pp. 537-579
    • Wakil, S.J.1    Stoops, J.K.2    Joshi, V.C.3
  • 145
    • 14444286453 scopus 로고    scopus 로고
    • S., Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway
    • Wang, D. and Sul, H. S., Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt, J Biol Chem 273 (1998) 25420-25426.
    • (1998) Involvement of protein kinase B/Akt, J Biol Chem , vol.273 , pp. 25420-25426
    • Wang, D.1    Sul, H.2
  • 146
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • Wang, H. Q.,Altomare, D.A., Skele, K. L., Poulikakos, P. I., Kuhajda, F. P., Di Cristofano, A. and Testa, J. R., Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells, Oncogene 24 (2005) 3574-3582.
    • (2005) Oncogene , vol.24 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di Cristofano, A.6    Testa, J.R.7
  • 148
    • 0032475841 scopus 로고    scopus 로고
    • Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein
    • Worgall, T. S., Sturley, S. L., Seo, T., Osborne, T. F. and Deckelbaum, R. J., Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein, J Biol Chem 273 (1998) 25537-25540.
    • (1998) J Biol Chem , vol.273 , pp. 25537-25540
    • Worgall, T.S.1    Sturley, S.L.2    Seo, T.3    Osborne, T.F.4    Deckelbaum, R.J.5
  • 151
    • 11844282154 scopus 로고    scopus 로고
    • C75 [4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic Acid] Activates Carnitine Palmitoyltransferase- 1 in Isolated Mitochondria and Intact Cells without Displacement of Bound Malonyl CoA
    • Yang, N., Kays, J. S., Skillman, T. R., Burris, L., Seng, T. W. and Hammond, C., C75 [4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic Acid] Activates Carnitine Palmitoyltransferase- 1 in Isolated Mitochondria and Intact Cells without Displacement of Bound Malonyl CoA, J Pharmacol Exp Ther 312 (2005) 127-133.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 127-133
    • Yang, N.1    Kays, J.S.2    Skillman, T.R.3    Burris, L.4    Seng, T.W.5    Hammond, C.6
  • 152
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang, Y. A., Han, W. F., Morin, P. J., Chrest, F. J. and Pizer, E. S., Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase, Exp Cell Res 279 (2002) 80-90.
    • (2002) Exp Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 153
    • 0033545848 scopus 로고    scopus 로고
    • From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    • Yeh, S., Lin, H.-K., Kang, H.-Y., Thin, T. H., Lin, M.-F. and Chang, C., From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells, Proc Natl Acad Sci USA 96 (1999) 5458-5463.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5458-5463
    • Yeh, S.1    Lin, H.-K.2    Kang, H.-Y.3    Thin, T.H.4    Lin, M.-F.5    Chang, C.6
  • 154
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • Yoon, S., Lee, M. Y., Park, S. W., Moon, J. S., Koh, Y. K., Ahn, Y. H., Park, B. W. and Kim, K. S., Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells, J Biol Chem 282 (2007) 26122-26131.
    • (2007) J Biol Chem , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3    Moon, J.S.4    Koh, Y.K.5    Ahn, Y.H.6    Park, B.W.7    Kim, K.S.8


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