Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET

Nuclear Medicine and Biology

Volumn 36, Issue 7, 2009, Pages 771-777

  Yoshii, Yukie ^a   Waki, Atsuo ^a   Furukawa, Takako ^b   Kiyono, Yasushi ^a   Mori, Tetsuya ^a,c   Yoshii, Hiroshi ^a   Kudo, Takashi ^a   Okazawa, Hidehiko ^a   Welch, Michael J ^c   Fujibayashi, Yasuhisa ^a,b  

^a UNIVERSITY OF FUKUI   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetate; Acetyl CoA synthetase; Hypoxia; PET; Tumor

Indexed keywords

ACETIC ACID; ACETIC ACID [1 C14]; ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE; MITOCHONDRIAL ENZYME; OXYGEN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; HYPOXIA; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; TUMOR CELL; TUMOR CELL LINE; TUMOR DIAGNOSIS; UPREGULATION;

ACETATE-COA LIGASE; ACETATES; ANIMALS; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CELL HYPOXIA; CELL LINE, TUMOR; CYTOSOL; GENE EXPRESSION REGULATION, NEOPLASTIC; ISOTOPE LABELING; MICE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVITY; TIME FACTORS;

EID: 69249232029     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.05.006     Document Type: Article

References (33)

1. Porenta G., Cherry S., Czernin J., Brunken R., Kuhle W., Hashimoto T., et al. Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging. Eur J Nucl Med 26 (1999) 1465-1474
2. Schelbert H.R. PET contributions to understanding normal and abnormal cardiac perfusion and metabolism. Ann Biomed Eng 28 (2000) 922-929
3. Henes C.G., Bergmann S.R., Walsh M.N., Sobel B.E., and Geltman E.M. Assessment of myocardial oxidative metabolic reserve with positron emission tomography and carbon-11 acetate. J Nucl Med 30 (1989) 1489-1499
4. Choi Y., Huang S.C., Hawkins R.A., Hoh C.K., Krivokapich J., Buxton D.B., et al. A refined method for quantification of myocardial oxygen consumption rate using mean transit time with carbon-11-acetate and dynamic PET. J Nucl Med 34 (1993) 2038-2043
5. Fujino T., Kondo J., Ishikawa M., Morikawa K., and Yamamoto T.T. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem 276 (2001) 11420-11426
6. Beinert H., Green D.E., Hele P., Hift H., Von Korff R.W., Ramakrishnan C.V., et al. The acetate activating enzyme system of heart muscle. J Biol Chem 203 (1953) 35-45
7. Hele P. The acetate activating enzyme of beef heart. J Biol Chem 206 (1954) 671-676
8. Brown M., Marshall D.R., Sobel B.E., and Bergmann S.R. Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation 76 (1987) 687-696
9. Buxton D.B., Nienaber C.A., Luxen A., Ratib O., Hansen H., Phelps M.E., et al. Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography. Circulation 79 (1989) 134-142
10. Klein L.J., Visser F.C., Knaapen P., Peters J.H., Teule G.J., Visser C.A., et al. Carbon-11 acetate as a tracer of myocardial oxygen consumption. Eur J Nucl Med 28 (2001) 651-668
11. Tamaki N., Magata Y., Takahashi N., Kawamoto M., Torizuka T., Yonekura Y., et al. Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion. Eur J Nucl Med 20 (1993) 231-237
12. Oyama N., Akino H., Kanamaru H., Suzuki Y., Muramoto S., Yonekura Y., et al. 11C-acetate PET imaging of prostate cancer. J Nucl Med 43 (2002) 181-186
13. Oyama N., Miller T.R., Dehdashti F., Siegel B.A., Fischer K.C., Michalski J.M., et al. 11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse. J Nucl Med 44 (2003) 549-555
14. Shreve P., Chiao P.C., Humes H.D., Schwaiger M., and Gross M.D. Carbon-11-acetate PET imaging in renal disease. J Nucl Med 36 (1995) 1595-1601
15. Ho C.L., Yu S.C., and Yeung D.W. 11C-acetate PET imaging in hepatocellular carcinoma and other liver masses. J Nucl Med 44 (2003) 213-221
16. Liu R.S., Chang C.P., Chu L.S., Chu Y.K., Hsieh H.J., Chang C.W., et al. PET imaging of brain astrocytoma with 1-11C-acetate. Eur J Nucl Med Mol Imaging 33 (2006) 420-427
17. Tsuchida T., Takeuchi H., Okazawa H., Tsujikawa T., and Fujibayashi Y. Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET. Nucl Med Biol 35 (2008) 171-176
18. Lear J.L., and Ackermann R.F. Evaluation of radiolabeled acetate and fluoroacetate as potential tracers of cerebral oxidative metabolism. Metab Brain Dis 5 (1990) 45-56
19. Sun L.Q., Mori T., Dence C.S., Ponde D.E., Welch M.J., Furukawa T., et al. New approach to fully automated synthesis of sodium [18F]fluoroacetate - a simple and fast method using a commercial synthesizer. Nucl Med Biol 33 (2006) 153-158
20. Ponde D.E., Dence C.S., Oyama N., Kim J., Tai Y.C., Laforest R., et al. 18F-fluoroacetate: a potential acetate analog for prostate tumor imaging-in vivo evaluation of 18F-fluoroacetate versus 11C-acetate. J Nucl Med 48 (2007) 420-428
21. Matthies A., Ezziddin S., Ulrich E.M., Palmedo H., Biersack H.J., Bender H., et al. Imaging of prostate cancer metastases with 18F-fluoroacetate using PET/CT. Eur J Nucl Med Mol Imaging 31 (2004) 797
22. Yoshimoto M., Waki A., Yonekura Y., Sadato N., Murata T., Omata N., et al. Characterization of acetate metabolism in tumor cells in relation to cell proliferation: acetate metabolism in tumor cells. Nucl Med Biol 28 (2001) 117-122
23. Hara T., Bansal A., and DeGrado T.R. Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells. Nucl Med Biol 33 (2006) 977-984
24. Yoshii Y., Furukawa T., Yoshii H., Mori T., Kiyono Y., Waki A., et al. Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Cancer Sci 100 (2009) 821-827
25. Scholl C., Bansal D., Dohner K., Eiwen K., Huntly B.J., Lee B.H., et al. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest 117 (2007) 1037-1048
26. Patel J.H., and McMahon S.B. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. J Biol Chem 282 (2007) 5-13
27. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37 (1959) 911-917
28. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT>>ΔΔCT Method. Methods 25 (2001) 402-408
29. Sone H., Shimano H., Sakakura Y., Inoue N., Amemiya-Kudo M., Yahagi N., et al. Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Am J Physiol 282 (2002) E222-E230
30. Luong A., Hannah V.C., Brown M.S., and Goldstein J.L. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem 275 (2000) 26458-26466
31. Löffler M., and Schneider F. Lipogenesis in Ehrlich ascites tumor cells under anaerobic culture conditions. J Cancer Res Clin Oncol 95 (1979) 115-122
32. Vāvere A.L., Kridel S.J., Wheeler F.B., and Lewis J.S. 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. J Nucl Med 49 (2008) 327-334
33. Furuta E., Pai S.K., Zhan R., Bandyopadhyay S., Watabe M., Mo Y.Y., et al. Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res 68 (2008) 1003-1011