Butyrylcholinesterase for protection from organophosphorus poisons: Catalytic complexities and hysteretic behavior

Archives of Biochemistry and Biophysics

Volumn 494, Issue 2, 2010, Pages 107-120

  Masson, Patrick ^a,b   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CENTRE DE RECHERCHES   (France)

Author keywords

Aryl acylamidase; Bioscavenger; Dehydroalanine; Hysteresis; Mass spectrometry; Phosphylation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMIDE; ARYL ACYLAMIDASE; BENZOYLCHOLINE; BUTYRYLCHOLINE; CHOLINESTERASE; DEHYDROALANINE; ECOTHIOPATE; ESTER; INDOLE DERIVATIVE; LYSINE; N METHYLINDOXYL ACETATE; NEUROTOXIN; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME; POISON; PRALIDOXIME; PROCAINAMIDE; PROTEXIA; SCAVENGER; SERINE; TETRAMER; TYROSINE; UNCLASSIFIED DRUG;

AGING; CHEMICAL MODIFICATION; CLINICAL TRIAL; DEALKYLATION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME REACTIVATION; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; HYSTERESIS; INTOXICATION; MASS SPECTROMETRY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BIOCATALYSIS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 75549088598     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.12.005     Document Type: Review

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