Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BMC Biotechnology

Volumn 8, Issue , 2008, Pages

  Huang, Yue Jin ^a   Lundy, Paul M ^b   Lazaris, Anthoula ^a,d   Huang, Yue ^a   Baldassarre, Hernan ^a   Wang, Bin ^a,e   Turcotte, Carl ^a   Côté, Mélanie ^a   Bellemare, Annie ^a   Bilodeau, Annie S ^a   Brouillard, Sandra ^a   Touati, Madjid ^a   Herskovits, Peter ^a   Bégin, Isabelle ^a   Neveu, Nathalie ^a   Brochu, Eric ^a   Pierson, Janice ^a   Hockley, Duncan K ^a   Cerasoli, Douglas M ^c   Lenz, David E ^c   Wilgus, Harvey ^a   Karatzas, Costas N ^a,f   Langermann, Solomon ^a   more..

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e NewLife Fertility Centre   (Canada)

^f CNKonsulting and Aegis Bioresearch   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOASSAY; DIMERS; DRUG PRODUCTS; MOLECULAR MASS; MONOMERS; PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY;

ELLMAN ASSAY; FUSION PROTEIN; HUMAN BUTYRYLCHOLINESTERASE; HUMAN SERUM ALBUMIN;

PHARMACOKINETICS;

ANTIDOTE; DIMER; HYBRID PROTEIN; MONOMER; ORGANOPHOSPHORUS COMPOUND; PESTICIDE; RECOMBINANT BUTYRYLCHOLINESTERASE; RECOMBINANT BUTYRYLCHOLINESTERASE HUMAN SERUM ALBUMIN FUSION PROTEIN; RECOMBINANT ENZYME; TETRAMER; CHOLINESTERASE; SERUM ALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG FORMULATION; DRUG PURIFICATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPRESSION VECTOR; FEMALE; GEL PERMEATION CHROMATOGRAPHY; GOAT; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA HALF LIFE; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SWINE; WESTERN BLOTTING; ANIMAL; BLOOD; CELL LINE; ENZYMOLOGY; GENETICS; HAMSTER; HUMAN; KIDNEY; METABOLIC CLEARANCE RATE; METHODOLOGY; PROTEIN ENGINEERING; TRANSGENIC MOUSE;

CAPRA HIRCUS; MUS MUSCULUS; SUIDAE;

ANIMALS; BUTYRYLCHOLINESTERASE; CELL LINE; CRICETINAE; GOATS; HUMANS; KIDNEY; METABOLIC CLEARANCE RATE; MICE; MICE, TRANSGENIC; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN; SWINE;

EID: 44849117242     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-8-50     Document Type: Article

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