Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7593-7603

  Sanson, Benoît ^a   Nachon, Florian ^b   Colletier, Jacques Philippe ^a   Froment, Marie Thérèse ^b   Toker, Lilly ^c   Greenblatt, Harry M ^c   Sussman, Joel L ^c   Ashani, Yaacov ^c   Masson, Patrick ^a,b   Silman, Israel ^c   Weik, Martin ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b CENTRE DE RECHERCHES   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; HISTONE; OXIME; PHOSPHORUS; PRALIDOXIME; SOMAN; TERNARY COMPLEX FACTOR;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CHEMICAL PHENOMENA; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG CONJUGATION; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME REACTIVATION; NONHUMAN; STEREOISOMERISM; TORPEDO CALIFORNICA; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ANIMALS; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DEALKYLATION; ENZYME ACTIVATION; HUMANS; KINETICS; MODELS, MOLECULAR; PRALIDOXIME COMPOUNDS; SOMAN; TORPEDO; WATER;

EID: 69549106972     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900433t     Document Type: Article

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