메뉴 건너뛰기




Volumn 16, Issue 10, 2009, Pages 1207-1214

Human carboxylesterases: An update on CES1, CES2 and CES3

Author keywords

Alignment; Alternative splicing; Carboxylesterase; Drug metabolism; Enzyme kinetics; Homology modeling; Hydrolase; Review; Single nucleotide polymorphisms; Splice variants; Substrate specificity

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 2, HUMAN;

EID: 69549137840     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986609789071324     Document Type: Article
Times cited : (112)

References (48)
  • 1
    • 40349098592 scopus 로고    scopus 로고
    • Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs
    • Hosokawa, M. Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs. Molecules, 2008, 13(2), 412-431.
    • (2008) Molecules , vol.13 , Issue.2 , pp. 412-431
    • Hosokawa, M.1
  • 3
    • 33748744628 scopus 로고    scopus 로고
    • Structure, function and regulation of carboxylesterases
    • Satoh, T.; Hosokawa, M. Structure, function and regulation of carboxylesterases. Chem. Biol. Interact., 2006, 162(3), 195-211.
    • (2006) Chem. Biol. Interact. , vol.162 , Issue.3 , pp. 195-211
    • Satoh, T.1    Hosokawa, M.2
  • 4
    • 33749030999 scopus 로고    scopus 로고
    • Human carboxylesterase isozymes: Catalytic properties and rational drug design
    • Imai, T. Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug. Metab. Pharmacokinet., 2006, 21(3), 173-185.
    • (2006) Drug. Metab. Pharmacokinet. , vol.21 , Issue.3 , pp. 173-185
    • Imai, T.1
  • 5
    • 14644422580 scopus 로고    scopus 로고
    • Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics
    • Redinbo, M.R.; Potter, P.M. Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics. Drug Discov. Today, 2005, 10(5), 313-325.
    • (2005) Drug Discov. Today , vol.10 , Issue.5 , pp. 313-325
    • Redinbo, M.R.1    Potter, P.M.2
  • 6
    • 0025723458 scopus 로고
    • Cloning and analysis of a cDNA encoding a human liver carboxylesterase
    • Riddles, P.W.; Richards, L.J.; Bowles, M.R.; Pond, S.M. Cloning and analysis of a cDNA encoding a human liver carboxylesterase. Gene, 1991, 108(2), 289-292.
    • (1991) Gene , vol.108 , Issue.2 , pp. 289-292
    • Riddles, P.W.1    Richards, L.J.2    Bowles, M.R.3    Pond, S.M.4
  • 7
    • 0025990496 scopus 로고
    • A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases
    • Munger, J.S.; Shi, G.P.; Mark, E.A.; Chin, D.T.; Gerard, C.; Chapman, H.A. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. J. Biol. Chem., 1991, 266(28), 18832-18838.
    • (1991) J. Biol. Chem. , vol.266 , Issue.28 , pp. 18832-18838
    • Munger, J.S.1    Shi, G.P.2    Mark, E.A.3    Chin, D.T.4    Gerard, C.5    Chapman, H.A.6
  • 9
    • 0030809784 scopus 로고    scopus 로고
    • Human liver carboxylesterase hCE-1: Binding specificity for cocaine, heroin, and their metabolites and analogs
    • Brzezinski, M.R.; Spink, B.J.; Dean, R.A.; Berkman, C.E.; Cashman, J.R.; Bosron, W.F. Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs. Drug Metab. Dispos., 1997, 25(9), 1089-1096.
    • (1997) Drug Metab. Dispos. , vol.25 , Issue.9 , pp. 1089-1096
    • Brzezinski, M.R.1    Spink, B.J.2    Dean, R.A.3    Berkman, C.E.4    Cashman, J.R.5    Bosron, W.F.6
  • 11
    • 0242600811 scopus 로고    scopus 로고
    • Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
    • Bencharit, S.; Morton, C.L.; Xue, Y.; Potter, P.M.; Redinbo, M.R. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nat. Struct. Biol., 2003, 10(5), 349-356.
    • (2003) Nat. Struct. Biol. , vol.10 , Issue.5 , pp. 349-356
    • Bencharit, S.1    Morton, C.L.2    Xue, Y.3    Potter, P.M.4    Redinbo, M.R.5
  • 12
    • 0030965160 scopus 로고    scopus 로고
    • Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin
    • DOI 10.1074/jbc.272.23.14769
    • Pindel, E.V.; Kedishvili, N.Y.; Abraham, T.L.; Brzezinski, M.R.; Zhang, J.; Dean, R.A.; Bosron, W.F. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. J. Biol. Chem., 1997, 272(23), 14769-14775. (Pubitemid 27251744)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.23 , pp. 14769-14775
    • Pindel, E.V.1    Kedishvili, N.Y.2    Abraham, T.L.3    Brzezinski, M.R.4    Zhang, J.5    Dean, R.A.6    Bosron, W.F.7
  • 13
    • 0031557664 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver
    • Schwer, H.; Langmann, T.; Daig, R.; Becker, A.; Aslanidis, C.; Schmitz, G. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. Biochem. Biophys. Res. Commun., 1997, 233(1), 117-120.
    • (1997) Biochem. Biophys. Res. Commun. , vol.233 , Issue.1 , pp. 117-120
    • Schwer, H.1    Langmann, T.2    Daig, R.3    Becker, A.4    Aslanidis, C.5    Schmitz, G.6
  • 18
    • 0032779726 scopus 로고    scopus 로고
    • Human carboxylesterases in term placentae: Enzymatic characterization, molecular cloning and evidence for the existence of multiple forms
    • Yan, B.; Matoney, L.; Yang, D. Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. Placenta, 1999, 20(7), 599-607.
    • (1999) Placenta , vol.20 , Issue.7 , pp. 599-607
    • Yan, B.1    Matoney, L.2    Yang, D.3
  • 19
    • 33846056843 scopus 로고    scopus 로고
    • Entrez Gene: Gene-centered information at NCBI
    • Maglott, D.; Ostell, J.; Pruitt, K.D.; Tatusova, T. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res., 2007, 35 (Database issue), D26-D31.
    • (2007) Nucleic Acids Res. , vol.35 , Issue.DATABASE ISSUE , pp. 26-31
    • Maglott, D.1    Ostell, J.2    Pruitt, K.D.3    Tatusova, T.4
  • 20
    • 33751527925 scopus 로고    scopus 로고
    • Development of bioinformatics resources for display and analysis of copy number and other structural variants in the human genome
    • Zhang, J.; Feuk, L.; Duggan, G.E.; Khaja, R.; Scherer, S.W. Development of bioinformatics resources for display and analysis of copy number and other structural variants in the human genome. Cytogenet. Genome Res., 2006, 115(3-4), 205-214.
    • (2006) Cytogenet. Genome Res. , vol.115 , Issue.3-4 , pp. 205-214
    • Zhang, J.1    Feuk, L.2    Duggan, G.E.3    Khaja, R.4    Scherer, S.W.5
  • 23
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • Venables, J.P. Aberrant and alternative splicing in cancer. Cancer Res., 2004, 64(21), 7647-7654.
    • (2004) Cancer Res. , vol.64 , Issue.21 , pp. 7647-7654
    • Venables, J.P.1
  • 24
    • 33748486517 scopus 로고    scopus 로고
    • AceView: A comprehensive cDNA-supported gene and transcripts annotation
    • Thierry-Mieg, D.; Thierry-Mieg, J. AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol., 2006, 7(Suppl 1), S12.
    • (2006) Genome Biol. , vol.7 , Issue.1 SUPPL.
    • Thierry-Mieg, D.1    Thierry-Mieg, J.2
  • 25
    • 0027427772 scopus 로고
    • Glycosylationdependent activity of baculovirus-expressed human liver carboxylesterases: CDNA cloning and characterization of two highly similar enzyme forms
    • Kroetz, D.L.; McBride, O.W.; Gonzalez, F.J. Glycosylationdependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. Biochemistry, 1993, 32(43), 11606-11617.
    • (1993) Biochemistry , vol.32 , Issue.43 , pp. 11606-11617
    • Kroetz, D.L.1    McBride, O.W.2    Gonzalez, F.J.3
  • 27
    • 0042868357 scopus 로고    scopus 로고
    • Characterization of multiple promoters in the human carboxylesterase 2 gene
    • Wu, M.H.; Chen, P.; Remo, B.F.; Cook, E.H.; Jr.; Das, S.; Dolan, M.E. Characterization of multiple promoters in the human carboxylesterase 2 gene. Pharmacogenetics., 2003, 13(7), 425-435.
    • (2003) Pharmacogenetics. , vol.13 , Issue.7 , pp. 425-435
    • Wu, M.H.1    Chen, P.2    Remo, B.F.3    Cook, Jr.E.H.4    Das, S.5    Dolan, M.E.6
  • 28
    • 2042544103 scopus 로고    scopus 로고
    • Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1- piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1- piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3
    • Sanghani, S.P.; Quinney, S.K.; Fredenburg, T.B.; Davis, W.I.; Murry, D.J.; Bosron, W.F. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1- piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1- piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab. Dispos., 2004, 32(5), 505-511.
    • (2004) Drug Metab. Dispos. , vol.32 , Issue.5 , pp. 505-511
    • Sanghani, S.P.1    Quinney, S.K.2    Fredenburg, T.B.3    Davis, W.I.4    Murry, D.J.5    Bosron, W.F.6
  • 29
    • 0038647390 scopus 로고    scopus 로고
    • Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population
    • Saito, S.; Iida, A.; Sekine, A.; Kawauchi, S.; Higuchi, S.; Ogawa, C.; Nakamura, Y. Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J. Hum. Genet., 2003, 48(5), 249-270.
    • (2003) J. Hum. Genet. , vol.48 , Issue.5 , pp. 249-270
    • Saito, S.1    Iida, A.2    Sekine, A.3    Kawauchi, S.4    Higuchi, S.5    Ogawa, C.6    Nakamura, Y.7
  • 31
    • 10044263002 scopus 로고    scopus 로고
    • Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38
    • Charasson, V.; Bellott, R.; Meynard, D.; Longy, M.; Gorry, P.; Robert, J. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. Clin. Pharmacol. Ther., 2004, 76(6), 528-535.
    • (2004) Clin. Pharmacol. Ther. , vol.76 , Issue.6 , pp. 528-535
    • Charasson, V.1    Bellott, R.2    Meynard, D.3    Longy, M.4    Gorry, P.5    Robert, J.6
  • 33
    • 4644275987 scopus 로고    scopus 로고
    • Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene
    • Wu, M.H.; Chen, P.; Wu, X.; Liu, W.; Strom, S.; Das, S.; Cook, E.H.; Jr.; Rosner, G.L.; Dolan, M.E. Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. Pharmacogenetics, 2004, 14(9), 595-605.
    • (2004) Pharmacogenetics , vol.14 , Issue.9 , pp. 595-605
    • Wu, M.H.1    Chen, P.2    Wu, X.3    Liu, W.4    Strom, S.5    Das, S.6    Cook, Jr.E.H.7    Rosner, G.L.8    Dolan, M.E.9
  • 34
    • 0345373886 scopus 로고    scopus 로고
    • Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: From binding promiscuity to selective inhibition
    • Bencharit, S.; Morton, C.L.; Hyatt, J.L.; Kuhn, P.; Danks, M.K.; Potter, P.M.; Redinbo, M.R. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem. Biol., 2003, 10(4), 341-349.
    • (2003) Chem. Biol. , vol.10 , Issue.4 , pp. 341-349
    • Bencharit, S.1    Morton, C.L.2    Hyatt, J.L.3    Kuhn, P.4    Danks, M.K.5    Potter, P.M.6    Redinbo, M.R.7
  • 38
    • 19444380386 scopus 로고    scopus 로고
    • Hydrolysis of capecitabine to 5'-deoxy- 5-fluorocytidine by human carboxylesterases and inhibition by loperamide
    • Quinney, S.K.; Sanghani, S.P.; Davis, W.I.; Hurley, T.D.; Sun, Z.; Murry, D.J.; Bosron, W.F. Hydrolysis of capecitabine to 5'-deoxy- 5-fluorocytidine by human carboxylesterases and inhibition by loperamide. J. Pharmacol. Exp. Ther., 2005, 313(3), 1011-1016.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , Issue.3 , pp. 1011-1016
    • Quinney, S.K.1    Sanghani, S.P.2    Davis, W.I.3    Hurley, T.D.4    Sun, Z.5    Murry, D.J.6    Bosron, W.F.7
  • 39
    • 0346494961 scopus 로고    scopus 로고
    • ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins
    • Hotelier, T.; Renault, L.; Cousin, X.; Negre, V.; Marchot, P.; Chatonnet, A. ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Nucleic Acids Res., 2004, 32 (Database issue), D145-D147.
    • (2004) Nucleic Acids Res. , vol.32 , Issue.DATABASE ISSUE , pp. 145-147
    • Hotelier, T.1    Renault, L.2    Cousin, X.3    Negre, V.4    Marchot, P.5    Chatonnet, A.6
  • 40
    • 0027948970 scopus 로고
    • Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine
    • Brzezinski, M.R.; Abraham, T.L.; Stone, C.L.; Dean, R.A.; Bosron, W.F. Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem. Pharmacol., 1994, 48(9), 1747-1755.
    • (1994) Biochem. Pharmacol. , vol.48 , Issue.9 , pp. 1747-1755
    • Brzezinski, M.R.1    Abraham, T.L.2    Stone, C.L.3    Dean, R.A.4    Bosron, W.F.5
  • 42
    • 0031800635 scopus 로고    scopus 로고
    • The mammalian carboxylesterases: From molecules to functions
    • Satoh, T.; Hosokawa, M. The mammalian carboxylesterases: from molecules to functions. Annu. Rev. Pharmacol. Toxicol., 1998, 38, 257-288.
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 257-288
    • Satoh, T.1    Hosokawa, M.2
  • 43
    • 0025955766 scopus 로고
    • Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine
    • Dean, R.A.; Christian, C.D.; Sample, R.H.; Bosron, W.F. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J., 1991, 5(12), 2735-2739.
    • (1991) FASEB J. , vol.5 , Issue.12 , pp. 2735-2739
    • Dean, R.A.1    Christian, C.D.2    Sample, R.H.3    Bosron, W.F.4
  • 44
    • 0036142253 scopus 로고    scopus 로고
    • Lessons from a bacterial cocaine esterase
    • Bosron, W.F.; Hurley, T.D. Lessons from a bacterial cocaine esterase. Nat. Struct. Biol., 2002, 9(1), 4-5.
    • (2002) Nat. Struct. Biol. , vol.9 , Issue.1 , pp. 4-5
    • Bosron, W.F.1    Hurley, T.D.2
  • 45
    • 33748901615 scopus 로고    scopus 로고
    • Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
    • Imai, T.; Taketani, M.; Shii, M.; Hosokawa, M.; Chiba, K. Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine. Drug Metab. Dispos., 2006, 34(10), 1734-1741.
    • (2006) Drug Metab. Dispos. , vol.34 , Issue.10 , pp. 1734-1741
    • Imai, T.1    Taketani, M.2    Shii, M.3    Hosokawa, M.4    Chiba, K.5
  • 47
    • 0031461193 scopus 로고    scopus 로고
    • Carboxylesterasemediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: Preliminary in vitro findings using a rat liver preparation
    • Bourland, J.A.; Martin, D.K.; Mayersohn, M. Carboxylesterasemediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation. J. Pharm. Sci., 1997, 86(12), 1494-1496.
    • (1997) J. Pharm. Sci. , vol.86 , Issue.12 , pp. 1494-1496
    • Bourland, J.A.1    Martin, D.K.2    Mayersohn, M.3
  • 48
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg, M.; Sim, S.C.; Gomez, A.; Rodriguez-Antona, C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther., 2007, 116(3), 496-526.
    • (2007) Pharmacol. Ther. , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.