Developing procedures for the large-scale purification of human serum butyrylcholinesterase

Protein Expression and Purification

Volumn 61, Issue 2, 2008, Pages 191-196

  Saxena, Ashima ^a   Luo, Chunyuan ^a   Doctor, Bhupendra P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Butyrylcholinesterase; Cohn Fraction IV 4; Human plasma; Purification; Specific activity

Indexed keywords

CHOLINESTERASE; COHN FRACTION IV; DRUG DERIVATIVE; PLASMA PROTEIN; PROCAINAMIDE; SEPHAROSE;

AFFINITY CHROMATOGRAPHY; ARTICLE; BLOOD; CHEMISTRY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY; PLASMA; SENSITIVITY AND SPECIFICITY;

BLOOD PROTEINS; BUTYRYLCHOLINESTERASE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, DEAE-CELLULOSE; CHROMATOGRAPHY, ION EXCHANGE; HUMANS; PLASMA; PROCAINAMIDE; SENSITIVITY AND SPECIFICITY; SEPHAROSE;

EID: 50049116598     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2008.05.021     Document Type: Article

References (33)

1. Lockridge O. Structure of human serum cholinesterase. Bioessays 9 (1988) 125-128
2. Lockridge O., Bartels C.F., Vaughan T.A., Wong C.K., Norton S.E., and Johnson L.L. Complete amino acid sequence of human serum cholinesterase. J. Biol. Chem. 262 (1987) 549-557
3. McTiernan C., Adkins S., Chatonnet A., Vaughan T.A., Bartels C.F., Knott M., Rosenberry T.L., La Du B.N., and Lockridge O. Brain cDNA clone for human cholinesterase. Proc. Natl. Acad. Sci. USA 84 (1987) 6682-6686
4. Saxena A., Ashani Y., Raveh L., Stevenson D., Patel T., and Doctor B.P. Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases. Mol. Pharm. 53 (1998) 112-122
5. Broomfield C.A., Maxwell D.M., Solana R.P., Castro C.A., Finger A.V., and Lenz D.E. Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates. J. Pharmacol. Exp. Ther. 259 (1991) 633-638
6. Ashani Y., Shapira S., Levy D., Wolfe A.D., Doctor B.P., and Raveh L. Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice. Biochem. Pharmacol. 41 (1991) 37-41
7. Wolfe A.D., Blick D.W., Murphy M.R., Miller S.A., Gentry M.K., Hargraves S.L., and Doctor B.P. Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity. Toxicol. Appl. Pharmacol. 117 (1992) 189-193
8. Brandeis R., Raveh L., Grunwald J., Cohen E., and Ashani Y. Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats. Pharmacol. Biochem. Behav. 46 (1993) 889-896
9. Raveh L., Grunwald J., Marcus D., Papier Y., Cohen E., and Ashani Y. Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. Biochem. Pharmacol. 45 (1993) 2465-2474
10. Raveh L., Grauer E., Grunwald J., Cohen E., and Ashani Y. The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase. Toxicol. Appl. Pharmacol. 145 (1997) 43-53
11. Ashani Y. Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs. Drug Dev. Res. 50 (2000) 298-308
12. Jenkins T., Balinsky D., and Patient D.W. Cholinesterase in plasma: first reported absence in the Bantu: half-life determination. Science 156 (1967) 1748-1750
13. Ostergaard D., Viby-Mogensen J., Hanel H.K., and Skovgaard L.T. Half-life of plasma cholinesterase. Acta Anaesthesiol. Scand. 32 (1988) 266-269
14. Cascio C., Comite C., Ghira M., Lanza G., and Ponchione A. The use of serum cholinesterase in severe phosphorus poisoning. Personal experience. Minerva Anesthesiol. 54 (1988) 337-338
15. Stovner J., and Stadskleiv K. Suxamethonium apnea terminated with commercial serum cholinesterase. Acta Anaesthesiol. Scand. 20 (1976) 211-215
16. Hoffman R.S., Morasco R., and Goldfrank L.R. Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice. J. Toxicol. Ciln. Toxicol. 34 (1996) 259-266
17. Lynch T.J., Mattes C.E., Singh A., Bradley R.M., Brady R.O., and Dretchen K.L. Cocaine detoxification by human plasma butyrylcholinesterase. Toxicol. Appl. Pharmacol. 145 (1997) 363-371
18. Carmona G.N., Schindler C.W., Shoaib M., Jufer R., Cone E.J., Goldberg S.R., Greig N.H., Yu Q.S., and Gorelick D.A. Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase. Exp. Clin. Psychopharmacol. 6 (1998) 274-279
19. Duysen E.G., Bartels C.F., and Lockridge O. Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-h half-life in the circulation and protect mice from cocaine toxicity. J. Pharmacol. Exp. Ther. 302 (2002) 751-758
20. Sun H., Shen M.L., Pang Y.P., Lockridge O., and Brimijoin S. Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J. Pharmacol. Exp. Ther. 302 (2002) 710-716
21. Lockridge O. Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. Pharmacol. Ther. 47 (1990) 35-60
22. Ralston J.C., Main A.R., Kilpatrick B.F., and Chasson A.L. Use of procainamide gels in the purification of human and horse serum cholinesterases. Biochem. J. 211 (1983) 243-250
23. Grunwald J., Marcus D., Papier Y., Raveh L., Pittel Z., and Ashani Y. Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug. J. Biochem. Biophys. Methods 34 (1997) 123-135
24. De La Hoz D., Doctor B.P., Ralston J.S., Rush R.S., and Wolfe A.D. A simplified procedure for the purification of acetylcholinesterase from fetal bovine serum. Life Sci. 39 (1986) 195-199
25. Surgenor D.M., and Ellis D. Preparation and properties of serum and plasma proteins. Plasma cholinesterase. J. Am. Chem. Soc. 76 (1954) 6049-6051
26. Ellman G.L., Courtney K.D., Andres V., and Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
27. Layne E. Spectrophotometric and turbidometric methods for measuring proteins. Methods Enzymol. 3 (1957) 447-454
28. Lockridge O., and La Du B. Comparison of atypical and usual human serum cholinesterase. J. Biol. Chem. 253 (1978) 361-366
29. Karnovsky M.J., and Roots L. A direct-coloring thiocholine method for cholinesterases. J. Histochem. Cytochem. 12 (1964) 219-221
30. Laemmeli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
31. Mattes C.E., Bradley R., Slaughter E., and Browne S. Cocaine and butyrylcholinesterase (BChE): determination of enzymatic parameters. Life Sci. 58 (1996) 257-261
32. Lockridge O., and La Du B. Loss of interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholinesterase. J. Biol. Chem. 257 (1982) 12012-12018
33. Lockridge O., Schopfer L.M., Winger G., and Woods J.H. Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys; a potential new therapeutic for protection against cocaine and nerve agent toxicity. J. Med. Chem. Biol. Radiol. Def. 3 (2005) 5095