Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: The crystal structure suggests two alternative mechanisms of aging

Biochemistry

Volumn 44, Issue 4, 2005, Pages 1154-1162

  Nachon, Florian ^a,b   Asojo, Oluwatoyin A ^a   Borgstahl, Gloria E O ^a   Masson, Patrick ^b   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CENTRE DE RECHERCHES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGING OF MATERIALS; CHEMICAL BONDS; CRYSTAL STRUCTURE; ENZYMES; ISOMERS; PESTICIDES; REACTION KINETICS; WATER;

CATALYTIC TRIAD HISTIDINES; ECHOTHIOPHATE; HUMAN BUTYLCHOLINESTERASES; ORGANOPHOSPHORUS POISONS (OP);

ENZYME INHIBITION;

CARBON; CHOLINESTERASE INHIBITOR; ECOTHIOPATE; GLUTAMINE; HISTIDINE; ISOMALATHION; MALATHION; NERVE GAS; ORGANOPHOSPHORUS COMPOUND; OXIME; OXYGEN; SARIN; SERINE; SOMAN; TABUN; UNCLASSIFIED DRUG; WATER;

AGING; ARTICLE; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PESTICIDE SPRAYING; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOISOMERISM; STRUCTURE ANALYSIS; TORPEDO CALIFORNICA;

ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CATALYSIS; CHOLINESTERASE INHIBITORS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ECHOTHIOPHATE IODIDE; GLUTAMIC ACID; GLYCEROL; HISTIDINE; HUMANS; HYDROLYSIS; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDE FRAGMENTS; THIOPHOSPHORIC ACID ESTERS; TORPEDO; WATER;

TORPEDO; TORPEDO CALIFORNICA;

EID: 13444261934     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048238d     Document Type: Article

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