Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 35, 2006, Pages 13220-13225

  Albuquerque, Edson X ^a   Pereira, Edna F R ^a   Aracava, Yasco ^a   Fawcett, William P ^a   Oliveira, Maristela ^a   Randall, William R ^a   Hamilton, Tracey A ^b   Kan, Robert K ^b   Romano Jr , James A ^c   Adler, Michael ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^c U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

Author keywords

Galantamine; Guinea pig; Pyridostigmine; Sarin; Soman

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; CHOLINESTERASE INHIBITOR; DRUG METABOLITE; GALANTAMINE; HUPERZINE A; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NEUROTRANSMITTER; ORGANOPHOSPHATE INSECTICIDE; ORGANOPHOSPHORUS COMPOUND; PARAOXON; PARATHION; PYRIDOSTIGMINE; SARIN; SOMAN; TABUN;

ACUTE TOXICITY; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME INACTIVATION; ENZYME INHIBITION; GUINEA PIG; INTOXICATION; LETHAL DOSE; LETHALITY; MALE; METABOLITE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; ANIMALS; ATROPINE; BEHAVIOR, ANIMAL; BRAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GALANTAMINE; GUINEA PIGS; INSECTICIDES; LETHAL DOSE 50; NEURONS; ORGANOPHOSPHORUS COMPOUNDS; PARAOXON; POISONING; PYRIDOSTIGMINE BROMIDE; SARIN; SESQUITERPENES; SOMAN; TIME FACTORS;

CAVIA; CAVIA PORCELLUS;

EID: 33748366780     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605370103     Document Type: Article

References (41)

1. Coupland, R. & Leins, K. R. (2005) Science 308, 1841.
2. Romano, J. A., Jr., & King, J. M. (2001) Mil. Med. 166, 21-22.
3. Karalliedde, L. & Senanayake, N. (1989) Br. J. Anaesth. 65, 736-750.
4. Buckley, N. A., Karalliedde, L., Dawson, A., Senanayake, N. & Eddleston, M. (2004) J. Toxicol. Clin. Toxicol. 42, 113-116.
5. Bajgar, J. (2004) Adv. Clin. Chem. 38, 151-216.
6. Doctor, B. P., Raveh, L., Wolfe, A. D., Maxwell, D. M. & Ashani, Y. (1991) Neurosci. Biobehav. Rev. 15, 123-128.
7. Ghanem, E. & Raushel, F. M. (2005) Toxicol. Appl. Pharmacol. 207, 459-470.
8. Wetherell, J., Hall, T. & Passingham, S. (2002) Neurotoxicology 23, 341-349.
9. Leadbeater, L., Inns, R. H. & Rylands, J. M. (1985) Fundam. Appl. Toxicol. 5, S225-S231.
10. Deshpande, S. S., Viana, G. B., Kauffman, F. C., Rickett, D. L. & Albuquerque, E. X. (1986) Fundam. Appl. Toxicol. 6, 566-577.
11. Grunwald, J., Raveh, L., Doctor, B. P. & Ashani, Y. (1994) Life Sci. 54, 991-997.
12. Fricke, R. F., Koplovitz. I., Scharf, B. A., Rockwood, G. A., Olson, C. T., Hobson, D. W. & Blank, J. A. (1994) Drug Chem. Toxicol. 17, 15-34.
13. Lallement, G., Baille, V., Baubichon, D., Carpentier, P., Collombet, J. M., Filliat, P., Foquin, A., Four, E., Masqueliez, C., Testylier, G., et al. (2002) Neurotoxicology 23, 1-5.
14. Corey-Bloom, J. (2003) Int. J. Clin. Pract. 57, 219-223.
15. Dreyer, R. (1968) Muench. Med. Wochenschr. 110, 1481.
16. Losev, N. A. & Tkachenko, E. I. (1986) Biull. Eksp. Biol Med. 101, 436-438.
17. Pereira, E. F. R., Hilmas, C., Santos, M. D., Alkondon, M., Maelicke, A. & Albuquerque, E. X. (2002) J. Neurobiol. 53, 479-500.
18. Arias, E., Ales, E., Gabilan, N. H., Cano-Abad, M. F., Villarroya, M., Garcia, A. G. & Lopez, M. G. (2004) Neuropharmacology 46, 103-114.
19. Kihara, T., Sawada, H., Nakamizo, T., Kanki, R., Yamashita, H., Maelicke, A. & Shimohama, S. (2004) Biochem. Biophys. Res. Commun. 325, 976-982.
20. Shih, T. M., Duniho, S. M. & McDonough, J. H. (2003) Toxicol Appl. Pharmacol. 188, 69-80.
21. Maxwell, D. M., Brecht, K. M., Lenz, D. E. & O'Neill, B. L. (1988) J. Pharmacol. Exp. Ther. 246, 986-991.
22. Carter, W. H., Jones, D. E. & Carchman, R. A. (1985) Fundam. Appl. Toxicol. 5, S232-S241.
23. Silvestre, J. S., Fernandez, A. G. & Palacios, J. M. (1999) Pharmacol. Biochem. Behav. 64, 1-5.
24. Gordon, R. K., Nigam, S. V., Weitz, J. A., Dave, J. R., Doctor, B. P. & Vedr, H. S. (2001) J. Appl. Toxicol. 21, S47-S51.
25. Koek, W., Woods, J. H. & Winger, G. D. (1988) J. Pharmacol. Exp. Ther. 245, 969-974.
26. Bickel, U., Thomsen, T., Weber, W., Fischer, J. P., Bachus, R., Nitz, M. & Kewitz, H. (1991) Clin. Pharmacol. Ther. 50, 420-428.
27. Mihailova, D., Yamboliev, I., Zhivkova, Z., Tencheva, J. & Jovovich, V. (1989) Pharmacology 39, 50-58.
28. Jann, M. W., Shirley, K. L. & Small, G. W. (2002) Clin. Pharmacokinet. 41, 719-739.
29. Thomsen, T., Kaden, B., Fischer, J. P., Bickel, U., Barz, H., Gusztony, G., Cervos-Navarro, J. & Kewitz, H. (1991) Eur. J. Clin. Chem. Clin. Biochem. 29, 487-492.
30. Thomsen, T. & Kewitz, H. (1990) Life Sci. 46, 1553-1558.
31. McDonough, J. H. & Shih, T. M. (1997) Neurosci. Biobehav. Rev. 21, 559-579.
32. Filliat, P., Baubichon, D., Burckhart, M. F., Pernot-Marino, I., Foquin, A., Masqueliez, C., Perrichon, C., Carpentier, P. & Lallement, G. (1999) Neurotoxicology 20, 535-549.
33. Myhrer, T., Andersen, J. M., Nguyen, N. H. & Aas, P. (2005) Neurotoxicology 26, 39-48.
34. Nakamizo, T., Kawamata, J., Yamashita, H., Kanki, R., Kihara, T., Sawada, H., Akaike, A. & Shimohama, S. (2005) Biochem. Biophys. Res. Commun. 330, 1285-1289.
35. Capsoni, S., Giannotta, S. & Cattaneo, A. (2002) Proc. Natl. Acad. Sci. USA 99, 12432-12437.
36. Tondulli, L. S., Testylier, G., Marino, I. P. & Lallement, G. (1999) J. Neurosci. Res. 58, 464-473.
37. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals (National Academy Press, Washington, DC).
38. Schmued, L. C. & Hopkins, K. J. (2000) Brain Res. 874, 123-130.
39. Claessens, H. A., van Thiel, M., Westra, P. & Soeterboek, A. M. (1983) J. Chromatogr. 275, 345-353.
40. Johnson, C. D. & Russell, R. L. (1975) Anal. Biochem. 64, 229-238.
41. June, H. L., Duemler, S. E., Greene, T. L., Williams, J. A., Lin, M., Devaraju, S. L., Chen, S. H., Lewis, M. J. & Murphy, J. M. (1995) J. Pharmacol. Exp. Ther. 274, 1105-1112.