Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1774, Issue 1, 2007, Pages 16-34

  Masson, Patrick ^a   Froment, Marie Thérèse ^a   Gillon, Emilie ^a   Nachon, Florian ^a   Lockridge, Oksana ^b   Schopfer, Lawrence M ^b  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Butyrylcholinesterase; Ester; Mutation; Oxyanion hole; Rate limiting step; Thio ester

Indexed keywords

ALCOHOL; ANION; BENZOYLCHOLINE; BENZOYLTHIOCHOLINE; CATION; CHOLINE DERIVATIVE; CHOLINESTERASE; ESTER DERIVATIVE; MUTANT PROTEIN; PHENYLACETIC ACID; PHENYLTHIOACETIC ACID; THIOESTER; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE; HYDROLYSIS; MATHEMATICAL ANALYSIS; MOLECULAR SIZE; MUTATION; PRIORITY JOURNAL; WILD TYPE;

ACYLATION; AMINO ACID SUBSTITUTION; BENZOYLCHOLINE; BUTYRYLCHOLINESTERASE; GLYCOLATES; HUMANS; HYDROLYSIS; KINETICS; PHENYLACETATES; PHOSPHORIC ACID ESTERS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOCHOLINE;

EID: 33845982954     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2006.10.012     Document Type: Article

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