Acetylcholinesterase: Converting a vulnerable target to a template for antidotes and detection of inhibitor exposure

Toxicology

Volumn 233, Issue 1-3 SPEC. ISS., 2007, Pages 70-78

  Taylor, Palmer ^a   Kovarik, Zrinka ^a,b   Reiner, Elsa ^b   Radić, Zoran ^c  

^a San Diego   (United States)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^c NONE

Author keywords

Catalytic scavenging; Organophosphate antidotes; Organophosphate detection; Oxime catalysis; Reactivation chemistry

Indexed keywords

ACETYLCHOLINESTERASE; ANTIDOTE; CHOLINESTERASE INHIBITOR; NERVE GAS; ORGANOPHOSPHATE; OXIME; PESTICIDE; REAGENT;

ARTICLE; CONJUGATION; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME MODIFICATION; EXPOSURE; FLUORESCENCE; HYDROLYSIS; MUTATION; PHOSPHORYLATION; PLASMA; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; REMOTE SENSING; SENSOR; SYNTHESIS;

ACETYLCHOLINESTERASE; ANTIDOTES; BINDING, COMPETITIVE; CATALYSIS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG DESIGN; HUMANS; HYDROLYSIS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; POISONING; SPECTROMETRY, FLUORESCENCE;

EID: 33947630408     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.11.061     Document Type: Article

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