Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates

Toxicology

Volumn 233, Issue 1-3 SPEC. ISS., 2007, Pages 79-84

  Kovarik, Zrinka ^a,b   Radić, Zoran ^a   Berman, Harvey A ^c   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Acetylcholinesterase; Nerve agent antidotes; Organophosphates; Oximes; Reactivation; Scavengers

Indexed keywords

ACETYLCHOLINESTERASE; CYCLOHEPTYLMETHYLPHOSPHONYLTHIOCHOLINE; METHYLPHOSPHONIC ACID; ORGANOPHOSPHATE; OXIME; PHOSPHONIC ACID DERIVATIVE; REAGENT; THIOCHOLINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONJUGATE; CONJUGATION; DEGRADATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROLYSIS; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; SPECTROPHOTOMETRY; WILD TYPE;

ACETYLCHOLINESTERASE; ANIMALS; CATALYSIS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MICE; MOLECULAR STRUCTURE; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 33947661567     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.08.032     Document Type: Article

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