Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase

Toxicology and Applied Pharmacology

Volumn 196, Issue 3, 2004, Pages 356-366

  Wang, Yuxia ^a,b   Boeck, Andreea Ticu ^a   Duysen, Ellen G ^a   Van Keuren, Margaret ^c   Saunders, Thomas L ^c,d   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Butyrylcholinesterase; Echothiophate; Insecticide Resistance; Organophosphorus; Organophosphorus toxicants; Pesticide resistance; Transgenic mice; Transgenic mouse

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINESTERASE; ECOTHIOPATE; MUTANT PROTEIN; ORGANOPHOSPHORUS COMPOUND;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISEASE RESISTANCE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FEMALE; FERTILITY; GENE CONTROL; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC RESISTANCE; HEART; HYDROLYSIS; INTESTINE; KIDNEY; LD 50; LETHALITY; LIVER; LUNG; MALE; MOUSE; MUSCLE; NONHUMAN; PLASMA; PROMOTER REGION; PROTEIN EXPRESSION; SPLEEN; STOMACH; TOXICITY; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOTHIOPHATE IODIDE; GENETIC ENGINEERING; HUMANS; MICE; MICE, TRANSGENIC; ORGANOPHOSPHORUS COMPOUNDS; PROTEINS; TISSUE DISTRIBUTION;

ANIMALIA; MUS MUSCULUS; VERTEBRATA;

EID: 1942439688     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.12.018     Document Type: Article

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