Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

Toxicological Sciences

Volumn 100, Issue 1, 2007, Pages 136-145

  Li, He ^a   Schopfer, Lawrence M ^a   Nachon, Florian ^b   Froment, Marie Thérèse ^b   Masson, Patrick ^b   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CENTRE DE RECHERCHES   (France)

Author keywords

Aging; Butyrylcholinesterase; Mass spectrometry; Organophosphate

Indexed keywords

CHOLINESTERASE; CYCLOSARIN; DICHLORVOS; DIISOPROPYL FLUOROPHOSPHATASE; ECOTHIOPATE; MALATHION; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHATE; SARIN; SOMAN;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; CONJUGATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; HUMAN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTEIN ANALYSIS;

BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DEUTERIUM OXIDE; DICHLORVOS; ECHOTHIOPHATE IODIDE; ENZYME STABILITY; HUMANS; INSECTICIDES; ISOFLUROPHATE; MALATHION; MOLECULAR STRUCTURE; PEPTIDE MAPPING; SARIN; SERINE; SOMAN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TRYPSIN;

EID: 35448956936     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm215     Document Type: Article

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