Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

Biochemical Journal

Volumn 421, Issue 1, 2009, Pages 97-106

  Carletti, Eugénie ^a   Aurbek, Nadine ^b   Gillon, Emilie ^a   Loiodice, Mélanie ^a   Nicolet, Yvain ^c   Fontecilla Camps, Juan Carlos ^c   Masson, Patrick ^a   Thiermann, Horst ^b   Nachon, Florian ^a   Worek, Franz ^b  

^a CENTRE DE RECHERCHES   (France)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Aging; Butyrylcholinesterase; Kinetics; Oxime reactivation; Tabun analogues; X ray crystallography

Indexed keywords

AGING; AMINO GROUP; BINDING POCKETS; BUTYRYLCHOLINESTERASE; ELECTRONIC EFFECTS; METHOXY; MONO-ALKYL CHAIN; N-PROPYL; O-DEALKYLATION; OBIDOXIME; OXIME REACTIVATION; PHASE I; PHOSPHORAMIDATE; PHOSPHORAMIDATES; PRE-TREATMENT; PYRIDINIUM; REFINED STRUCTURES; SALT BRIDGES; STRUCTURAL BASIS; STRUCTURE ACTIVITY RELATIONSHIPS; STRUCTURE-ACTIVITY; TABUN ANALOGUES; TIME-DEPENDENT PROCESS; TRIMETHYLENE; X RAY DATA; X-RAY STRUCTURE;

AMINATION; AMINES; MINERALOGY; SELF ASSEMBLY;

X RAY CRYSTALLOGRAPHY;

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; CHOLINESTERASE; OBIDOXIME; OXIME DERIVATIVE; PHOSPHORAMIDIC ACID; TABUN; TRIMEDOXIME; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; ORGANOPHOSPHATE; OXIME;

AGING; ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEALKYLATION; ENANTIOMER; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REACTIVATION; HUMAN; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYME ACTIVE SITE; KINETICS; METABOLISM; PROTEIN CONFORMATION; TIME;

BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIMES; PHOSPHORIC ACID ESTERS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 67650324928     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090091     Document Type: Article

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