Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates

Biochemical and Biophysical Research Communications

Volumn 355, Issue 4, 2007, Pages 1069-1074

  Schallreuter, Karin U ^a,b   Gibbons, Nicholas C J ^a,b   Elwary, Souna M ^a   Parkin, Susan M ^a   Wood, John M ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Calcium; EF hand; Human epidermis; Hydrogen peroxide; Organophosphates

Indexed keywords

ACETYLCHOLINESTERASE; CALCIUM; CALCIUM 45; CHOLINESTERASE; HYDROGEN PEROXIDE; ORGANOPHOSPHATE; PHENYLPHOSPHONOTHIOIC ACID O ETHYL O (4 NITROPHENYL) ESTER; PROTEIN SUBUNIT;

AFFINITY LABELING; ARTICLE; BINDING SITE; CALCIUM BINDING; COMPUTER SIMULATION; ENZYME ACTIVITY; HUMAN; HYDROLYSIS; NEUROTOXICITY; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; SKIN SURFACE; SURFACE PROPERTY;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; BINDING SITES; BUTYRYLCHOLINESTERASE; CALCIUM; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; EF HAND MOTIFS; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; HYDROLYSIS; MODELS, MOLECULAR; NEUROTOXINS; OXIDATION-REDUCTION; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SKIN;

EID: 33847666802     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.078     Document Type: Article

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