Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

Journal of the American Chemical Society

Volumn 130, Issue 47, 2008, Pages 16011-16020

  Carletti, Eugénie ^a   Li, He ^b   Li, Bin ^b   Ekström, Fredrik ^c   Nicolet, Yvain ^d   Loiodice, Mélanie ^a   Gillon, Emilie ^a   Froment, Marie T ^a   Lockridge, Oksana ^b   Schopfer, Lawrence M ^b   Masson, Patrick ^a   Nachon, Florian ^a  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^d INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; AMINATION; AMINO ACIDS; BIOMARKERS; CRYSTALLOGRAPHY; ESTERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC COMPOUNDS; OXYGEN; PESTICIDES; PHOSPHORUS; REFINING; SPECTROMETRY;

3D DATUMS; ACETYLCHOLINESTERASE; ACUTE TOXICITIES; AGING REACTIONS; CARBAMATE PESTICIDES; DEALKYLATION; DEAMIDATION; DEPENDENT PROCESSES; DIMETHYLAMINE; MASS SPECTROMETRIC ANALYSIS; NERVE AGENTS; ORGANO-PHOSPHATES; ORGANOPHOSPHORUS PESTICIDES; PROTONATED; REFINED STRUCTURES; SALT BRIDGES; SIDE CHAINS; STRUCTURAL BASES;

ENZYME INHIBITION;

ACETYLCHOLINESTERASE; CHOLINESTERASE; DIMETHYLAMINE; OXIME DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; SERINE DERIVATIVE; TABUN;

AGING; ARTICLE; CATALYSIS; CHO CELL; CONJUGATION; CRYSTAL STRUCTURE; DEALKYLATION; DEAMINATION; ENANTIOMER; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; MASS SPECTROMETRY; PROTEIN STRUCTURE; PROTON TRANSPORT; X RAY CRYSTALLOGRAPHY;

ALKYLATION; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORIC ACID ESTERS; PHOSPHORYLATION;

EID: 56749185596     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja804941z     Document Type: Article

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