Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1764, Issue 9, 2006, Pages 1470-1478

  Poyot, Thomas ^a   Nachon, Florian ^a   Froment, Marie Thérèse ^a   Loiodice, Mélanie ^a   Wieseler, Stacy ^b   Schopfer, Lawrence M ^b   Lockridge, Oksana ^b   Masson, Patrick ^a  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Acetylcholinesterase; Molecular modelling; Organophosphate hydrolase activity; Organophosphorus inhibitors; Site directed mutagenesis; Slow binding inhibition

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ORGANOPHOSPHATE; PEPTIDE;

ARTICLE; BUNGARUS FASCIATUS; CONCENTRATION (PARAMETERS); ENZYME ACTIVITY; HYDROLYSIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; SNAKE; WILD TYPE;

ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ANIMALS; BUNGARUS; CHLORPYRIFOS; DISULFOTON; ECHOTHIOPHATE IODIDE; ISOFLUROPHATE; MUTAGENESIS, SITE-DIRECTED; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; PARAOXON;

BUNGARUS FASCIATUS;

EID: 33748446276     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2006.07.008     Document Type: Article

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