Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin

Biochemistry

Volumn 48, Issue 15, 2009, Pages 3425-3435

  Epstein, Todd M ^a   Samanta, Uttamkumar ^a   Kirby, Stephen D ^a,b   Cerasoli, Douglas M ^b   Bahnson, Brian J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ACTIVE SITES; BOVINE BRAINS; CHIRAL COLUMNS; ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; GAS CHROMATOGRAPHY/MASS SPECTROMETRIES; HYDROLASE; NERVE AGENTS; NERVE SYNAPSIS; PARAOXON; PHOSPHOLIPASE A2; PHOSPHONYLATION; POTENT INHIBITORS; SECONDARY PROCESS; SERINE HYDROLASES; STEREO-SELECTIVE; STRUCTURAL INSIGHTS;

AMINO ACIDS; ELECTROSPRAY IONIZATION; IONIZATION OF GASES; ISOMERS; MASS SPECTROMETRY; SPECTROMETERS; STEREOSELECTIVITY;

ENZYMES;

ACETYLCHOLINESTERASE; DYFLOS; PARAOXON; PHOSPHOLIPASE A2; SARIN; SERINE DEHYDRATASE; SOMAN; TRYPSIN;

AGING; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CHEMICAL STRUCTURE; CONTROLLED STUDY; COW; CRYSTAL STRUCTURE; ELECTROSPRAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GAS CHROMATOGRAPHY; ISOMER; MASS SPECTROMETER; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ACETYLCHOLINESTERASE; ANIMALS; BRAIN; CATTLE; CHEMICAL WARFARE AGENTS; CRYSTALLOGRAPHY, X-RAY; DEALKYLATION; HUMANS; INSECTICIDES; PARAOXON; SARIN; SOMAN; SYNAPSES;

BOVINAE;

EID: 65349183403     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8023527     Document Type: Article

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