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Volumn 11, Issue 1, 2010, Pages 36-40

Autoimmunity: Increasing suspects in the CD4 + T cell lineup

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 17; CYTOKINE;

EID: 74049099080     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1802     Document Type: Review
Times cited : (85)

References (86)
  • 1
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli, P. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1
  • 2
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld, D. et al. Follicular B helper T cells express CXC chemokine receptor 5, Localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192, 1545-1552 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 3
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva, R.I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138-149 (2008).
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1
  • 4
    • 45149123617 scopus 로고    scopus 로고
    • Development and characterization of IL-21-producing CD4+ T cells
    • Suto, A. et al. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205, 1369-1379 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1369-1379
    • Suto, A.1
  • 5
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 Are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston, R.J. et al. Bcl6 and Blimp-1 Are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 6
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • Nurieva, R.I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 7
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457-468 (2009).
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 8
    • 34547232503 scopus 로고    scopus 로고
    • H17 cells
    • H17 cells. Nature 448, 484-487 (2007).
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 9
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva, R. et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448, 480-483 (2007).
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1
  • 10
    • 34547188748 scopus 로고    scopus 로고
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967-974 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 967-974
    • Zhou, L.1
  • 11
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang, A. et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137 (2008).
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 12
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 13
    • 0028077321 scopus 로고
    • IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by iFN-γ
    • Schmitt, E. et al. IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by iFN-γ. J. Immunol. 153, 3989-3996 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 3989-3996
    • Schmitt, E.1
  • 14
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen, M. et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 9, 1341-1346 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen, M.1
  • 15
    • 56349093347 scopus 로고    scopus 로고
    • - Effector T cells
    • - Effector T cells. Nat. Immunol. 9, 1347-1355 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1347-1355
    • Dardalhon, V.1
  • 16
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic Effector TH17 and Regulatory T cells. Nature 441, 235-238 (2006).
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 17
    • 33646560950 scopus 로고    scopus 로고
    • H17 lineage
    • H17 lineage. Nature 441, 231-234 (2006).
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 18
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine mILieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & stockinger, B. TGFβ in the context of an inflammatory cytokine mILieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006).
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 19
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh, C.S. et al. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21, 267-277 (2004)
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.S.1
  • 20
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive Regulatory and nonRegulatory T cell receptor repertoires
    • Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D. & Rudensky, A.Y. An intersection between the self-reactive Regulatory and nonRegulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 21
    • 0032128287 scopus 로고    scopus 로고
    • Anti-idiotypic antibodies prevent the sero-logic detection of antiribosomal P autoantibodies in healthy adults
    • Pan, Z.J., Anderson, C.J. & stafford, H.A. Anti-idiotypic antibodies prevent the sero-logic detection of antiribosomal P autoantibodies in healthy adults. J. Clin. Invest. 102, 215-222 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 215-222
    • Pan, Z.J.1    Anderson, C.J.2    Stafford, H.A.3
  • 22
    • 44449135894 scopus 로고    scopus 로고
    • The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes
    • Oak, S. et al. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes. Proc. Natl. Acad. Sci. USA 105, 5471-5476 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 5471-5476
    • Oak, S.1
  • 23
    • 0028323456 scopus 로고
    • Faecal diversion for Crohn's colitis: A model to study the role of the faecal stream in the inflammatory process
    • Winslet, M.C., Allan, A., Poxon, V., Youngs, D. & Keighley, M.R. Faecal diversion for Crohn's colitis: a model to study the role of the faecal stream in the inflammatory process. Gut 35, 236-242 (1994).
    • (1994) Gut , vol.35 , pp. 236-242
    • Winslet, M.C.1    Allan, A.2    Poxon, V.3    Youngs, D.4    Keighley, M.R.5
  • 24
    • 53649100675 scopus 로고    scopus 로고
    • H17 cell differentiation
    • H17 cell differentiation. Nature 455, 808-812 (2008).
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1
  • 25
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits Regulatory T cell conversion and is a natural adjuvant of intestinal Immune responses
    • Hall, J.A. et al. Commensal DNA limits Regulatory T cell conversion and is a natural adjuvant of intestinal Immune responses. Immunity 29, 637-649 (2008).
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1
  • 26
    • 23344449020 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease reveal innate, adaptive, and Regulatory mechanisms of host dialogue with the microbiota
    • Elson, C.O. et al. Experimental models of inflammatory bowel disease reveal innate, adaptive, and Regulatory mechanisms of host dialogue with the microbiota. Immunol. Rev. 206, 260-276 (2005).
    • (2005) Immunol. Rev. , vol.206 , pp. 260-276
    • Elson, C.O.1
  • 27
    • 46949104323 scopus 로고    scopus 로고
    • IL-12-and IL-23-modulated T cells induce distinct types of eAe based on histology, CNs chemokine profILe, and response to cytokine Inhibition
    • Kroenke, M.A., Carlson, T.J., Andjelkovic, A.V. & Segal, B.M. IL-12-and IL-23-modulated T cells induce distinct types of eAe based on histology, CNs chemokine profILe, and response to cytokine Inhibition. J. Exp. Med. 205, 1535-1541 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 28
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 Effector response can drive autoimmunity: Conditions of disease induction affect dominant Effector category
    • Luger, D. et al. Either a Th17 or a Th1 Effector response can drive autoimmunity: conditions of disease induction affect dominant Effector category. J. Exp. Med. 205, 799-810 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 799-810
    • Luger, D.1
  • 29
    • 0037033434 scopus 로고    scopus 로고
    • T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
    • Iqbal, N. et al. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 195, 71-84 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 71-84
    • Iqbal, N.1
  • 30
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • Lee, Y.K. et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30, 92-107 (2009).
    • (2009) Immunity , vol.30 , pp. 92-107
    • Lee, Y.K.1
  • 31
    • 63449096041 scopus 로고    scopus 로고
    • Follicular helper T cells are required for systemic autoim-munity
    • Linterman, M.A. et al. Follicular helper T cells are required for systemic autoim-munity. J. Exp. Med. 206, 561-576 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 561-576
    • Linterman, M.A.1
  • 32
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of sTAT4 and sTAT6 on the induction of experimental autoImmune encephalomyelitis
    • Chitnis, T. et al. Effect of targeted disruption of sTAT4 and sTAT6 on the induction of experimental autoImmune encephalomyelitis. J. Clin. Invest. 108, 739-747 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 739-747
    • Chitnis, T.1
  • 33
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not sTAT1, prevents the development of experimental autoImmune encephalomyelitis
    • Bettelli, E. et al. Loss of T-bet, but not sTAT1, prevents the development of experimental autoImmune encephalomyelitis. J. Exp. Med. 200, 79-87 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 79-87
    • Bettelli, E.1
  • 34
    • 58049194071 scopus 로고    scopus 로고
    • Emergence of the Th17 pathway and its role in host defense
    • O'Quinn, D.B., Palmer, M.T., Lee, Y.K. & Weaver, C.T. Emergence of the Th17 pathway and its role in host defense. Adv. Immunol. 99, 115-163 (2008).
    • (2008) Adv. Immunol. , vol.99 , pp. 115-163
    • O'Quinn, D.B.1    Palmer, M.T.2    Lee, Y.K.3    Weaver, C.T.4
  • 35
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoImmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoImmune demyelination
    • Gran, B. et al. IL-12p35-deficient mice are susceptible to experimental autoImmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoImmune demyelination. J. Immunol. 169, 7104-7110 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 7104-7110
    • Gran, B.1
  • 36
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue, S. et al. interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2473-2483
    • Hue, S.1
  • 37
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg, M.C. et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. exp. Med. 203, 2485-2494 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1
  • 38
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1310-1316
    • Yen, D.1
  • 39
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoImmune encephalitis and inflammation in the absence of interleukin-12
    • Becher, B., Durell, B.G. & Noelle, R.J. experimental autoImmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110, 493-497 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 40
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoImmune inflammation
    • Murphy, C.A. et al. Divergent pro-and antiinflammatory roles for IL-23 and IL-12 in joint autoImmune inflammation. J. Exp. Med. 198, 1951-1957 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1951-1957
    • Murphy, C.A.1
  • 41
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoImmune inflammation of the brain
    • Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoImmune inflammation of the brain. Nature 421, 744-748 (2003).
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 42
    • 0037442020 scopus 로고    scopus 로고
    • Induction of experimental autoImmune encephalomyelitis in IL-12 receptor-β2-deficient mice: IL-12 responsiveness is not required in the pathogen-esis of inflammatory demyelination in the central nervous system
    • Zhang, G.X. et al. Induction of experimental autoImmune encephalomyelitis in IL-12 receptor-β2-deficient mice: IL-12 responsiveness is not required in the pathogen-esis of inflammatory demyelination in the central nervous system. J. Immunol. 170, 2153-2160 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2153-2160
    • Zhang, G.X.1
  • 43
    • 27544490377 scopus 로고    scopus 로고
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • + Effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 44
    • 0037037582 scopus 로고    scopus 로고
    • Interferon gamma is required for activation-induced death of T lymphocytes
    • Refaeli, Y., Van Parijs, L., Alexander, S.I. & Abbas, A.K. Interferon gamma is required for activation-induced death of T lymphocytes. J. Exp. Med. 196, 999-1005 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 999-1005
    • Refaeli, Y.1    Van Parijs, L.2    Alexander, S.I.3    Abbas, A.K.4
  • 45
    • 0034601012 scopus 로고    scopus 로고
    • FaILure to suppress the expansion of the activated CD4 T cell population in Interferon γ-deficient mice leads to exacerbation of experimental autoImmune encephalomyelitis
    • Chu, C.Q., Wittmer, S. & Dalton, D.K. FaILure to suppress the expansion of the activated CD4 T cell population in Interferon γ-deficient mice leads to exacerbation of experimental autoImmune encephalomyelitis. J. Exp. Med. 192, 123-128 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 46
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1
  • 47
    • 34247247352 scopus 로고    scopus 로고
    • Interferon-gamma regulates susceptibILity to collagen-induced arthritis through suppression of interleukin-17
    • Chu, C.Q., swart, D., Alcorn, D., Tocker, J. & Elkon, K.B. Interferon-gamma regulates susceptibILity to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum. 56, 1145-1151 (2007).
    • (2007) Arthritis Rheum. , Issue.56 , pp. 1145-1151
    • Chu, C.Q.1    Swart, D.2    Alcorn, D.3    Tocker, J.4    Elkon, K.B.5
  • 48
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 famILy cytokines and the expanding diversity of Effector T cell lineageS
    • Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. IL-17 famILy cytokines and the expanding diversity of Effector T cell lineages. Annu. Rev. Immunol. 25, 821-852 (2007).
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 49
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to Regulatory T-cell function
    • Collison, L.W. et al. The inhibitory cytokine IL-35 contributes to Regulatory T-cell function. Nature 450, 566-569 (2007).
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1
  • 51
    • 59749103715 scopus 로고    scopus 로고
    • Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
    • Allan, S.E., song-Zhao, G.X., Abraham, T., McMurchy, A.N. & Levings, M.K. Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur. J. Immunol. 38, 3282-3289 (2008).
    • (2008) Eur J. Immunol. , vol.38 , pp. 3282-3289
    • Allan, S.E.1    Song-Zhao, G.X.2    Abraham, T.3    McMurchy, A.N.4    Levings, M.K.5
  • 52
    • 55149104594 scopus 로고    scopus 로고
    • Interleukin-35: Odd one out or part of the famILy?
    • Collison, L.W. & Vignali, D.A. Interleukin-35: odd one out or part of the famILy? Immunol. Rev. 226, 248-262 (2008).
    • (2008) Immunol. Rev. , vol.226 , pp. 248-262
    • Collison, L.W.1    Vignali, D.A.2
  • 53
    • 33747777440 scopus 로고    scopus 로고
    • Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
    • Becker, C. et al. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J. Immunol. 177, 2760-2764 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 2760-2764
    • Becker, C.1
  • 54
    • 0029034038 scopus 로고
    • Administration of interleukin 12 in combination with type ii collagen induces severe arthritis in DBA/1 mice
    • Germann, T. et al. Administration of interleukin 12 in combination with type ii collagen induces severe arthritis in DBA/1 mice. Proc. Natl. Acad. Sci. USA 92, 4823-4827 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4823-4827
    • Germann, T.1
  • 55
    • 0029965236 scopus 로고    scopus 로고
    • ReversibILity of T helper 1 and 2 populations is lost after long-term stimulation
    • Murphy, E. et al. ReversibILity of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183, 901-913 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 901-913
    • Murphy, E.1
  • 57
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt, R.L., Liang, H.E. & Locksley, R.M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10, 385-393 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 58
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • FazILleau, N., McHeyzer-WILliams, L.J., Rosen, H. & McHeyzer-WILliams, M.G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat. Immunol. 10, 375-384 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 59
    • 65549134481 scopus 로고    scopus 로고
    • H2 cells in response to helminth antigens
    • H2 cells in response to helminth antigens. J. Exp. Med. 206, 991-999 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 991-999
    • Zaretsky, A.G.1
  • 60
    • 65549114338 scopus 로고    scopus 로고
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 206, 1001-1007 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 61
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • Xu, L., Kitani, A., Fuss, I. & strober, W. Cutting edge: Regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178, 6725-6729 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 62
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of Regulatory and inflammatory T cell programs
    • Yang, X.O. et al. Molecular antagonism and plasticity of Regulatory and inflammatory T cell programs. Immunity 29, 44-56 (2008).
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1
  • 63
    • 55149094300 scopus 로고    scopus 로고
    • pos Regulatory T cells differentiate into IL-17-producing cells
    • pos Regulatory T cells differentiate into IL-17-producing cells. blood 112, 2340-2352 (2008).
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1
  • 64
    • 63849183918 scopus 로고    scopus 로고
    • + Regulatory T cells in humanS
    • + Regulatory T cells in humans. Proc. Natl. Acad. Sci. USA 106, 4793-4798 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4793-4798
    • Voo, K.S.1
  • 65
    • 58149214356 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Immunity 30, 155-167 (2009).
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1
  • 66
    • 60549115770 scopus 로고    scopus 로고
    • + T cells: A committed Regulatory T-cell lineage and an uncommitted minor population retaining plasticity
    • + T cells: a committed Regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl. Acad. Sci. USA 106, 1903-1908 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1
  • 67
    • 62449202866 scopus 로고    scopus 로고
    • + T cells in gut Peyer's patches
    • + T cells in gut Peyer's patches. Science 323, 1488-1492 (2009).
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1
  • 68
    • 58149216715 scopus 로고    scopus 로고
    • Th memory for interleukin-17 expression is stable in vivo
    • Lexberg, M.H. et al. Th memory for interleukin-17 expression is stable in vivo. Eur. J. Immunol. 38, 2654-2664 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2654-2664
    • Lexberg, M.H.1
  • 69
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoImmune inflammation
    • Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoImmune inflammation. J. exp. Med. 201, 233-240 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 233-240
    • Langrish, C.L.1
  • 70
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655-669 (2000).
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1
  • 71
    • 0035827347 scopus 로고    scopus 로고
    • H1 cells before IL-12-dependent selection
    • H1 cells before IL-12-dependent selection. Science 292, 1907-1910 (2001).
    • (2001) Science , vol.292 , pp. 1907-1910
    • Mullen, A.C.1
  • 72
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota, K. et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204, 2803-2812 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2803-2812
    • Hirota, K.1
  • 73
    • 65249175159 scopus 로고    scopus 로고
    • H-17 cells into the CNs through the choroid plexus is required for the initiation of eAe
    • H-17 cells into the CNs through the choroid plexus is required for the initiation of eAe. Nat. Immunol. 10, 514-523 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 514-523
    • Reboldi, A.1
  • 74
    • 67650650890 scopus 로고    scopus 로고
    • Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/sCiD recipient mice
    • Bending, D. et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/sCiD recipient mice. J. Clin. Invest. 119, 565-572 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 565-572
    • Bending, D.1
  • 75
    • 60549086638 scopus 로고    scopus 로고
    • Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    • Martin-Orozco, N., Chung, Y., Chang, S.H., Wang, Y.H. & Dong, C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 39, 216-224 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 216-224
    • Martin-Orozco, N.1    Chung, Y.2    Chang, S.H.3    Wang, Y.H.4    Dong, C.5
  • 76
    • 47649122633 scopus 로고    scopus 로고
    • Tumor-specific Th17-polarized cells eradicate large established melanoma
    • Muranski, P. et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. blood 112, 362-373 (2008).
    • (2008) Blood , vol.112 , pp. 362-373
    • Muranski, P.1
  • 78
    • 0028979121 scopus 로고
    • Biphasic Effect of Interferon-gamma in murine collagen-induced arthritiS
    • Boissier, M.C. et al. Biphasic Effect of Interferon-gamma in murine collagen-induced arthritis. Eur. J. Immunol. 25, 1184-1190 (1995).
    • (1995) Eur J. Immunol. , vol.25 , pp. 1184-1190
    • Boissier, M.C.1
  • 79
    • 33751506710 scopus 로고    scopus 로고
    • Interleukin-17 is a negative regulator of established allergic asthma
    • Schnyder-Candrian, S. et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203, 2715-2725 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2715-2725
    • Schnyder-Candrian, S.1
  • 80
    • 32444448971 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
    • Wang, J. et al. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J. Clin. Invest. 116, 414-421 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 414-421
    • Wang, J.1
  • 81
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cell-mediated intestinal inflammation
    • O'Connor, W. JR. et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat. Immunol. 10, 603-609 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 603-609
    • O'Connor, W.1
  • 82
    • 0028519015 scopus 로고
    • + T cells
    • + T cells. Immunity 1, 553-562 (1994).
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1
  • 83
    • 0030612240 scopus 로고    scopus 로고
    • + T cells from iFN-γ knockout mice do not induce wasting disease
    • + T cells from iFN-γ knockout mice do not induce wasting disease. J. Autoimmun. 10, 455-459 (1997).
    • (1997) J. Autoimmun. , vol.10 , pp. 455-459
    • Ito, H.1    Fathman, C.G.2
  • 84
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • NEurath, M.F. et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195, 1129-1143 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1129-1143
    • Neurath, M.F.1
  • 85
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (stat)-4 pathway, but is not conditional on Interferon-γ expression by T cells
    • simpson, S.J. et al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (stat)-4 pathway, but is not conditional on Interferon-γ expression by T cells. J. Exp. Med. 187, 1225-1234 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1225-1234
    • Simpson, S.J.1
  • 86
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • Elson, C.O. et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132, 2359-2370 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1


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