Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

Journal of Clinical Investigation

Volumn 116, Issue 2, 2006, Pages 414-421

  Wang, Jingsong ^a,b,d   Fathman, John W ^a   Lugo Villarino, Geanncarlo ^a   Scimone, Lucila ^c   Von Andrian, Ulrich ^c   Dorfman, David M ^b   Glimcher, Laurie H ^a,b,e,f  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d PFIZER INC   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

^f MannKind Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; COLLAGEN ANTIBODY; INTERLEUKIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; RAG2 PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR T BET;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN TISSUE; INFLAMMATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RHEUMATOID ARTHRITIS;

ADOPTIVE TRANSFER; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL MOVEMENT; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; DNA-BINDING PROTEINS; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 32444448971     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI26631     Document Type: Article

References (45)

1. Stastny, P. 1978. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N. Engl. J. Med. 298:869-871.
2. Firestein, G.S. 2003. Evolving concepts of rheumatoid arthritis. Nature. 423:356-361.
3. Plows, D., Kontogeorgos, G., and Kollias, G. 1999. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. J. Immunol. 162:1018-1023.
4. Santiago-Schwarz, F., Anand, P., Liu, S., and Carsons, S.E. 2001. Dendritic cells (DCs) in rheumatoid arthritis (RA): progenitor cells and soluble factors contained in RA synovial fluid yield a subset of myeloid DCs that preferentially activate Th1 inflammatory-type responses. J. Immunol. 167:1758-1768.
5. Matsumoto, I., Staub, A., Benoist, C., and Mathis, D. 1999. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science. 286:1732-1735.
6. Grant, E.P., et al. 2002. Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis. J. Exp. Med. 196:1461-1471.
7. Lee, D.M., et al. 2002. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science. 297:1689-1692.
8. Feldmann, M., and Maini, R.N. 2003. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat. Med. 9:1245-1250.
9. Szabo, S.J., et al. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 100:655-669.
10. Szabo, S.J., et al. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 295:338-342.
11. Avni, O., et al. 2002. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3:643-651.
12. Mullen, A.C., et al. 2002. Hlx is induced by and genetically interacts with T-bet to promote heritable Th1 gene induction. Nat. Immunol. 10:652-658.
13. Afkarian, M., et al. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 3:549-557.
14. Lighvani, A.A., et al. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. U. S. A. 98:15137-15142.
15. Mullen, A.C., et al. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 292:1907-1910.
16. Lametschwandtner, G., et al. 2004. Sustained expression of T-bet confers polarized human Th2 cells with Th1-like cytokine production and migratory capacities. J. Allergy Clin. Immun. 113:987-994.
17. Neurath, M.F., et al. 2002. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195:1129-1143.
18. Peng, S.L., Szabo, S.J., and Glimcher, L.H. 2002. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. U. S. A. 99:5545-5550.
19. Bettelli, E., et al. 2004. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200:79-87.
20. Juedes, A., Rodrigo, E., Togher, L., Glimcher, L.H., and von Herrath, M. 2004. T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J. Exp. Med. 199:1153-1162.
21. Lugo-Villarino, G., Maldonado-Lopez, R., Possemato, R., Penaranda, C., and Glimcher, L.H. 2003. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 100:7749-7754.
22. Townsend, M.J., et al. 2004. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 20:477-494.
23. Sullivan, B.M., et al. 2005. Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J. Immunol. 175:4593-4602.
24. Pearce, E.L., et al. 2003. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science. 302:1041-1043.
25. Terato, K., et al. 1992. Induction of arthritis with monoclonal antibodies to collagen. J. Immunol. 148:2103-2108.
26. McCoy, J.M., Wicks, J.R., and Audoly, L.P. 2002. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis. J. Clin. Invest. 110:651-658. doi:10.1172/JCI200215528.
27. Kagari, T., Doi, H., and Shimozato, T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J. Immunol. 169:1459-1466.
28. Turley, S.J. 2002. Dendritic cells: inciting and inhibiting autoimmunity. Curr. Opin. Immunol. 14:765-770.
29. Horai, R., et al. 2000. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191:313-320.
30. Sarkar, S., and Fox, D.A. 2005. Dendritic cells in rheumatoid arthritis. Front. Biosci. 10:656-665.
31. van den Berg, W.B. 1998. Joint inflammation and cartilage destruction may occur uncoupled. Springer Semin. Immunopathol. 20:149-164.
32. Soderlin, M.K., et al. 2003. Infections preceding early arthritis in southern Sweden: a prospective population-based study. J. Rheumatol. 30:459-464.
33. Horai, R., et al. 2004. TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J. Clin. Invest. 114:1603-1611. doi:10.1172/JCI200420742.
34. Link, H., Huang, Y.M., and Xiao, B.G. 1999. Dendritic cells in experimental allergic encephalomyelitis and multiple sclerosis. J. Neuroimmunol. 100:102-110.
35. Leung, B.P., et al. 2002. A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation. J. Immunol. 169:7071-7077.
36. Morita, Y., et al. 2001. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J. Clin. Invest. 107:1275-1284.
37. Tarner, I.H., et al. 2003. Treatment of autoimmune disease by adoptive cellular gene therapy. Ann. N. Y. Acad. Sci. 998:512-519.
38. Banchereau, J., and Steinman, R.M. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
39. Menten, P., et al. 2002. Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma. J. Leukoc. Biol. 72:780-789.
40. Schrum, S., Probst, P., Fleischer, B., and Zipfel, P.F. 1996. Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response. J. Immunol. 157:3598-3604.
41. Koch, A.E., et al. 1992. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90:772-779.
42. Koide, S.L., Inaba, K., and Steinman, R.M. 1987. Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J. Exp. Med. 165:515-530.
43. Von Stebut, E., et al. 2003. Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J. Exp. Med. 198:191-199.
44. Dorfman, D.M., Hwang, E.S., Shahsafaei, A., and Glimcher, L.H. 2004. T-bet, a T cell transcription factor, is expressed in a subset of B cell lymphoproliferative disorders. Am. J. Clin. Pathol. 122:292-297.
45. Weninger, W., Crowley, M.A., Manjunath, N., and von Andrian, U.H. 2001. Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194:953-966.