Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category

Journal of Experimental Medicine

Volumn 205, Issue 4, 2008, Pages 799-810

  Luger, Dror ^a   Silver, Phyllis B ^a   Tang, Jun ^a   Cua, Daniel ^b   Chen, Zoe ^b   Iwakura, Yoichiro ^c   Bowman, Edward P ^b   Sgambellone, Nicole M ^b   Chan, Chi Chao ^a   Caspi, Rachel R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE PREDISPOSITION; DISEASE SEVERITY; HELPER CELL; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SCORING SYSTEM; TH1 CELL; TH17 CELL; UVEITIS;

ANIMALS; ANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELL LINE; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; EYE; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-17; INTERLEUKIN-23; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; NEUTRALIZATION TESTS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; UP-REGULATION; UVEITIS;

EID: 42249084849     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071258     Document Type: Article

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