메뉴 건너뛰기




Volumn 184, Issue 2, 1996, Pages 473-483

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4;

EID: 0029839059     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.2.473     Document Type: Article
Times cited : (243)

References (57)
  • 1
    • 0022640843 scopus 로고
    • Two types of mouse helper T cell clone. I. Definition according to profile of lymphokine activities and secreted proteins
    • Mosmann, T.R., H. Cherwinski, M. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of mouse helper T cell clone. I. Definition according to profile of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.3    Giedlin, M.A.4    Coffman, R.L.5
  • 4
    • 0025789064 scopus 로고
    • B. burgdorfi activates T cells to produce a selective pattern of lymphokines in Lyme arthritis
    • Yssel, H., M.-C. Shanafelt, C. Soderberg, P.V. Schneider, J. Anzola, and G. Peltz. 1991. B. burgdorfi activates T cells to produce a selective pattern of lymphokines in Lyme arthritis. J. Exp. Med. 174:593-601.
    • (1991) J. Exp. Med. , vol.174 , pp. 593-601
    • Yssel, H.1    Shanafelt, M.-C.2    Soderberg, C.3    Schneider, P.V.4    Anzola, J.5    Peltz, G.6
  • 5
    • 0025807152 scopus 로고
    • Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen (s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 helper or type 2 helper) profile of cytokine production
    • Del Prete, G.F., M. De Carli, C. Mastromauro, R. Biagotti, D. Macchia, P. Falangiani, M. Ricci, and S. Romagnani. 1991. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen (s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 helper or type 2 helper) profile of cytokine production. J. Clin. Invest. 88:346-350.
    • (1991) J. Clin. Invest. , vol.88 , pp. 346-350
    • Del Prete, G.F.1    De Carli, M.2    Mastromauro, C.3    Biagotti, R.4    Macchia, D.5    Falangiani, P.6    Ricci, M.7    Romagnani, S.8
  • 9
    • 0025339467 scopus 로고
    • Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes
    • Andersson, U., J. Andersson, A. Lindfors, K. Wagner, G. Möller, and C.H. Heusser. 1990. Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur. J. Immunol. 20:1591-1596.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1591-1596
    • Andersson, U.1    Andersson, J.2    Lindfors, A.3    Wagner, K.4    Möller, G.5    Heusser, C.H.6
  • 10
    • 0027788043 scopus 로고
    • The relationship of IL-4- and IFN-γ - producing T cells studied by lineage ablation of IL-4-producing cells
    • Kamogawa, Y., L.A. Minasi, S.R. Carding, K. Bottomly, and R.A. Flavell. 1993. The relationship of IL-4- and IFN-γ - producing T cells studied by lineage ablation of IL-4-producing cells. Cell. 75:985-995.
    • (1993) Cell , vol.75 , pp. 985-995
    • Kamogawa, Y.1    Minasi, L.A.2    Carding, S.R.3    Bottomly, K.4    Flavell, R.A.5
  • 11
    • 0026571223 scopus 로고
    • T cell activation inducing epitopes of the house dust mite allergen Der p I. Induction of a restricted cytokine production profile of Der p I - Specific T cell clones upon antigen-specific activation
    • Yssel, H., K.E. Johnson, P.V. Schneider, J. Wideman, A. Terr, R. Kastelein, and J.E. de Vries. 1992. T cell activation inducing epitopes of the house dust mite allergen Der p I. Induction of a restricted cytokine production profile of Der p I - specific T cell clones upon antigen-specific activation. J. Immunol. 148:738-745.
    • (1992) J. Immunol. , vol.148 , pp. 738-745
    • Yssel, H.1    Johnson, K.E.2    Schneider, P.V.3    Wideman, J.4    Terr, A.5    Kastelein, R.6    De Vries, J.E.7
  • 12
    • 0028265155 scopus 로고
    • Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones
    • Manetti, R., F. Gerosa, M.G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Immunol. 179:1273-1283.
    • (1994) J. Immunol. , vol.179 , pp. 1273-1283
    • Manetti, R.1    Gerosa, F.2    Giudizi, M.G.3    Biagiotti, R.4    Parronchi, P.5    Piccinni, M.-P.6    Sampognaro, S.7    Maggi, E.8    Romagnani, S.9    Trinchieri, G.10
  • 14
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S.L., A.D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796-3806.
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 15
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4) - Producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells
    • Le Gros, G., S.Z. Ben-Sasson, R. Seder, F. Finkelman, and W.E. Paul. 1990. Generation of interleukin 4 (IL-4) - producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J. Exp. Med. 172: 921-929.
    • (1990) J. Exp. Med. , vol.172 , pp. 921-929
    • Le Gros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.4    Paul, W.E.5
  • 16
    • 0026648380 scopus 로고
    • Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell receptor transgenic system
    • Hsieh, C.S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89: 6065-6069.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6065-6069
    • Hsieh, C.S.1    Heimberger, A.B.2    Gold, J.S.3    O'Garra, A.4    Murphy, K.M.5
  • 18
    • 0028222035 scopus 로고
    • In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production
    • Demeure, C.E., C.Y. Wu, U. Shu, P.V. Schneider, C. Heusser, H. Yssel, and G. Delespesse. 1994. In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production. J. Immunol. 152:4775-4782.
    • (1994) J. Immunol. , vol.152 , pp. 4775-4782
    • Demeure, C.E.1    Wu, C.Y.2    Shu, U.3    Schneider, P.V.4    Heusser, C.5    Yssel, H.6    Delespesse, G.7
  • 19
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon-γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • Heinzel, F.P., M.D. Sadick, B.J. Holaday, R.L. Coffman, and R.M. Locksley. 1989. Reciprocal expression of interferon-γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59-72.
    • (1989) J. Exp. Med. , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 20
    • 0026500979 scopus 로고
    • IL-4 induces a Th2 response in Leishmania major-infected mice
    • Chatelain, R., K. Varkila, and R.L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182-1187.
    • (1992) J. Immunol. , vol.148 , pp. 1182-1187
    • Chatelain, R.1    Varkila, K.2    Coffman, R.L.3
  • 21
    • 0027491655 scopus 로고
    • + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
    • + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 23
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells
    • Manetti, R., P. Parronchi, M.G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177:199-204.
    • (1993) J. Exp. Med. , vol.177 , pp. 199-204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.-P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 25
    • 0028962552 scopus 로고
    • Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4
    • Mocci, S., and R.L. Coffman. 1995. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779-3787.
    • (1995) J. Immunol. , vol.154 , pp. 3779-3787
    • Mocci, S.1    Coffman, R.L.2
  • 26
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • Szabo, S.L., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2: 665-675.
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.L.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 27
    • 0023691037 scopus 로고
    • Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation
    • Peltz, G.A., M.L. Trounstine, and K.W. Moore. 1988. Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation. J. Immunol. 141: 1891-1896.
    • (1988) J. Immunol. , vol.141 , pp. 1891-1896
    • Peltz, G.A.1    Trounstine, M.L.2    Moore, K.W.3
  • 29
    • 0027196184 scopus 로고
    • Requirements for CD28-dependent T cell-mediated cytotoxicity
    • Azuma, M., M. Cayabyab, J.H. Phillips, and L.L. Lanier. 1993. Requirements for CD28-dependent T cell-mediated cytotoxicity. J. Immunol. 150:2091-2101.
    • (1993) J. Immunol. , vol.150 , pp. 2091-2101
    • Azuma, M.1    Cayabyab, M.2    Phillips, J.H.3    Lanier, L.L.4
  • 30
    • 0021015910 scopus 로고
    • Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines
    • Spits, H., G. Keizer, J. Horst, C. Terhorst, A. Hekman, and J.E. de Vries. 1983. Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma. 2:423-432.
    • (1983) Hybridoma , vol.2 , pp. 423-432
    • Spits, H.1    Keizer, G.2    Horst, J.3    Terhorst, C.4    Hekman, A.5    De Vries, J.E.6
  • 31
    • 0024576272 scopus 로고
    • Development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4
    • Chrétien, I., A. Van Kimmenade, M. Pearce, J. Banchereau, and J.S. Abrams. 1989. Development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4. J. Immunol. Methods. 117:67-81.
    • (1989) J. Immunol. Methods , vol.117 , pp. 67-81
    • Chrétien, I.1    Van Kimmenade, A.2    Pearce, M.3    Banchereau, J.4    Abrams, J.S.5
  • 33
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • Zurawski, S.M., F. Vega, Jr., B. Huyghe, and G. Zurawski. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO (Eur. Mol. Biol. Organ.) J. 12:2663-2670.
    • (1993) EMBO (Eur. Mol. Biol. Organ.) J. , vol.12 , pp. 2663-2670
    • Zurawski, S.M.1    Vega Jr., F.2    Huyghe, B.3    Zurawski, G.4
  • 34
    • 47049114626 scopus 로고
    • Immunoenzymatric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies
    • 6.20.1
    • Abrams, J.S. 1994. Immunoenzymatric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. Curr. Protocol Immunol. 6.20.1.
    • (1994) Curr. Protocol Immunol.
    • Abrams, J.S.1
  • 36
    • 0028267766 scopus 로고
    • Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells
    • Assenmacher, M., J. Schmitz, and A. Radbruch. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol. 24:1097-1101.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1097-1101
    • Assenmacher, M.1    Schmitz, J.2    Radbruch, A.3
  • 37
    • 0028877056 scopus 로고
    • Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations
    • Openshaw, P., E.E. Murphy, N.A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182:1-11.
    • (1995) J. Exp. Med. , vol.182 , pp. 1-11
    • Openshaw, P.1    Murphy, E.E.2    Hosken, N.A.3    Maino, V.4    Davis, K.5    Murphy, K.6    O'Garra, A.7
  • 38
    • 0029148642 scopus 로고
    • Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
    • Picker, L.J., M.K. Singh, Z. Zdraveski, J.R. Treer, S.L. Waldrop, P.B. Bergstresser, and V.C. Maino. 1995. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood. 86:1408-1419.
    • (1995) Blood , vol.86 , pp. 1408-1419
    • Picker, L.J.1    Singh, M.K.2    Zdraveski, Z.3    Treer, J.R.4    Waldrop, S.L.5    Bergstresser, P.B.6    Maino, V.C.7
  • 39
    • 0001094049 scopus 로고
    • Multicolor immunofluorescence and flow cytometry
    • Lanier, L.L., and D.J. Recktenwald. 1991. Multicolor immunofluorescence and flow cytometry. Methods (Orlando). 2:192-195.
    • (1991) Methods (Orlando) , vol.2 , pp. 192-195
    • Lanier, L.L.1    Recktenwald, D.J.2
  • 41
    • 0030002449 scopus 로고    scopus 로고
    • IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells
    • Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J.-Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol. 156:3159-3165.
    • (1996) J. Immunol. , vol.156 , pp. 3159-3165
    • Jeannin, P.1    Delneste, Y.2    Seveso, M.3    Life, P.4    Bonnefoy, J.-Y.5
  • 42
    • 0027435159 scopus 로고
    • An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: Support for a common component shared by IL-4 and IL-13 receptors
    • Aversa, G., J. Punnonen, B.G. Cocks, R. de Waal Malefyt, F. Vega, Jr., S.M. Zurawski, G. Zurawski, and J.E. de Vries. 1993. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J. Exp. Med. 178:2213-2218.
    • (1993) J. Exp. Med. , vol.178 , pp. 2213-2218
    • Aversa, G.1    Punnonen, J.2    Cocks, B.G.3    De Waal Malefyt, R.4    Vega Jr., F.5    Zurawski, S.M.6    Zurawski, G.7    De Vries, J.E.8
  • 43
    • 0028860632 scopus 로고
    • IL-4 induces human B cell maturation and IgE synthesis in SCID-hu mice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist
    • Carballido, J.M., D. Schols, R. Namikawa, S. Zurawski, G. Zurawski, M.-G. Roncarolo, and J.E. de Vries. 1995. IL-4 induces human B cell maturation and IgE synthesis in SCID-hu mice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist. J. Immunol. 155:4162-4170.
    • (1995) J. Immunol. , vol.155 , pp. 4162-4170
    • Carballido, J.M.1    Schols, D.2    Namikawa, R.3    Zurawski, S.4    Zurawski, G.5    Roncarolo, M.-G.6    De Vries, J.E.7
  • 44
    • 0021956725 scopus 로고
    • Impaired production of gamma interferon by newborn cells in vitro is due to a functionally immature macrophage
    • Taylor, S., and Y.J. Bryson. 1985. Impaired production of gamma interferon by newborn cells in vitro is due to a functionally immature macrophage. J. Immunol. 134:1493-1497.
    • (1985) J. Immunol. , vol.134 , pp. 1493-1497
    • Taylor, S.1    Bryson, Y.J.2
  • 45
    • 0026017325 scopus 로고
    • Differentiation of T cell lymphokine gene expression: The in vitro acquisition of T cell memory
    • Ehlers, S., and K.A. Smith. 1991. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J. Exp. Med. 173:25-36.
    • (1991) J. Exp. Med. , vol.173 , pp. 25-36
    • Ehlers, S.1    Smith, K.A.2
  • 46
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo, V.K., M.P. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, and L.H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 80:707-718.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3    Ranger, A.M.4    Zamvil, S.S.5    Sobel, R.A.6    Weiner, H.L.7    Nabavi, N.8    Glimcher, L.H.9
  • 47
    • 0029073050 scopus 로고
    • B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
    • Freeman, G.J., V.A. Boussiotis, A. Anumanthan, G.M. Bernstein, X.Y. Ke, P.D. Rennert, G.S. Gray, J.G. Gribben, and L.M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 2:523-532.
    • (1995) Immunity , vol.2 , pp. 523-532
    • Freeman, G.J.1    Boussiotis, V.A.2    Anumanthan, A.3    Bernstein, G.M.4    Ke, X.Y.5    Rennert, P.D.6    Gray, G.S.7    Gribben, J.G.8    Nadler, L.M.9
  • 48
    • 0028819315 scopus 로고
    • CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL
    • Lanier, L.L., S. O'Fallon, C. Somoza, J.H. Phillips, P.S. Linsley, K. Okumura, D. Ito, and M. Azuma. 1995. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97-105.
    • (1995) J. Immunol. , vol.154 , pp. 97-105
    • Lanier, L.L.1    O'Fallon, S.2    Somoza, C.3    Phillips, J.H.4    Linsley, P.S.5    Okumura, K.6    Ito, D.7    Azuma, M.8
  • 52
    • 0027492915 scopus 로고
    • Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-γ or IL-10
    • de Waal Malefyt, R., C.G. Figdor, R. Huijbens, S. Mohan-Peterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski, and J.E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-γ or IL-10. J. Immunol. 151:6370-6381.
    • (1993) J. Immunol. , vol.151 , pp. 6370-6381
    • De Waal Malefyt, R.1    Figdor, C.G.2    Huijbens, R.3    Mohan-Peterson, S.4    Bennett, B.5    Culpepper, J.6    Dang, W.7    Zurawski, G.8    De Vries, J.E.9
  • 57
    • 0028934155 scopus 로고
    • Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam
    • Nabors, G.S., L.C. Afonso, J.P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA. 92:3142-3146.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3142-3146
    • Nabors, G.S.1    Afonso, L.C.2    Farrell, J.P.3    Scott, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.