-
2
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211.
-
(2000)
Cell
, vol.103
, pp. 211
-
-
Schlessinger, J.1
-
3
-
-
0028838012
-
Dimerization of cell surface receptors in signal transduction
-
Heldin CH Dimerization of cell surface receptors in signal transduction. Cell 1995, 80:213.
-
(1995)
Cell
, vol.80
, pp. 213
-
-
Heldin, C.H.1
-
5
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835.
-
(1995)
Cell
, vol.83
, pp. 835
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
-
6
-
-
0029618368
-
Steroid hormone receptors: Many actors in search of a plot
-
Beato M, Herrlich P, Schutz G Steroid hormone receptors: many actors in search of a plot. Cell 1995, 83:851.
-
(1995)
Cell
, vol.83
, pp. 851
-
-
Beato, M.1
Herrlich, P.2
Schutz, G.3
-
7
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, et al. The protein kinase complement of the human genome. Science 2002, 298:1912.
-
(2002)
Science
, vol.298
, pp. 1912
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
-
8
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
Alonso A, Sasin J, Bottini N, et al. Protein tyrosine phosphatases in the human genome. Cell 2004, 117:699.
-
(2004)
Cell
, vol.117
, pp. 699
-
-
Alonso, A.1
Sasin, J.2
Bottini, N.3
-
9
-
-
0033786922
-
Protein tyrosine kinase structure and function
-
Hubbard SR, Till JH Protein tyrosine kinase structure and function. Annu Rev Biochem 2000, 69:373.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 373
-
-
Hubbard, S.R.1
Till, J.H.2
-
10
-
-
0035413607
-
Structural basis for control by phosphorylation
-
Johnson LN, Lewis RJ Structural basis for control by phosphorylation. Chem Rev 2001, 101:2209.
-
(2001)
Chem Rev
, vol.101
, pp. 2209
-
-
Johnson, L.N.1
Lewis, R.J.2
-
11
-
-
0034193568
-
Protein-protein interactions define specificity in signal transduction
-
Pawson T, Nash P Protein-protein interactions define specificity in signal transduction. Genes Dev 2000, 14:1027.
-
(2000)
Genes Dev
, vol.14
, pp. 1027
-
-
Pawson, T.1
Nash, P.2
-
12
-
-
0035313699
-
Phosphoserine/threonine-binding domains
-
Yaffe MB, Elia AE Phosphoserine/threonine-binding domains. Curr Opin Cell Biol 2001, 13:131.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 131
-
-
Yaffe, M.B.1
Elia, A.E.2
-
13
-
-
0036518996
-
Phosphotyrosine-binding domains in signal transduction
-
Yaffe MB Phosphotyrosine-binding domains in signal transduction. Nat Rev Mol Cell Biol 2002, 3:177.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 177
-
-
Yaffe, M.B.1
-
15
-
-
33745813187
-
Reading protein modifications with interaction domains
-
Seet B, Zhou M-M, Dikic I, et al. Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 2006, 7:473.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 473
-
-
Seet, B.1
Zhou, M.-M.2
Dikic, I.3
-
16
-
-
0030950608
-
Modular peptide recognition domains in eukaryotic signaling
-
Kuriyan J, Cowburn D Modular peptide recognition domains in eukaryotic signaling. Annu Rev Biophys Biomol Struct 1997, 26:259.
-
(1997)
Annu Rev Biophys Biomol Struct
, vol.26
, pp. 259
-
-
Kuriyan, J.1
Cowburn, D.2
-
17
-
-
0027409064
-
Binding of a high affinity phosphotyrosyl peptide in the src
-
Waksman G, Shoelson S, Pant N, et al. Binding of a high affinity phosphotyrosyl peptide in the src. Cell 1993, 72:779.
-
(1993)
Cell
, vol.72
, pp. 779
-
-
Waksman, G.1
Shoelson, S.2
Pant, N.3
-
19
-
-
0027403027
-
Identification of phosphotyrosine peptide motifs which bind to SH2 domains
-
Songyang Z, Shoelson SE, Chadhuri M, et al. Identification of phosphotyrosine peptide motifs which bind to SH2 domains. Cell 1993, 72:767.
-
(1993)
Cell
, vol.72
, pp. 767
-
-
Songyang, Z.1
Shoelson, S.E.2
Chadhuri, M.3
-
20
-
-
33745185987
-
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling
-
Liu BA, Jabonowski K, Raina M, et al. The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell 2006, 22:851.
-
(2006)
Mol Cell
, vol.22
, pp. 851
-
-
Liu, B.A.1
Jabonowski, K.2
Raina, M.3
-
21
-
-
0029871708
-
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
-
Muslin AJ, Tanner JW, Allen PM, et al. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 1996, 84:889.
-
(1996)
Cell
, vol.84
, pp. 889
-
-
Muslin, A.J.1
Tanner, J.W.2
Allen, P.M.3
-
24
-
-
0035975965
-
Modular phosphoinositide- binding domains-their role in signaling and membrane trafficking
-
Cullen PJ, Cozier GE, Banting G, et al. Modular phosphoinositide- binding domains-their role in signaling and membrane trafficking. Curr Biol 2001, 11:R882-R893.
-
(2001)
Curr Biol
, vol.11
, pp. R882-R893
-
-
Cullen, P.J.1
Cozier, G.E.2
Banting, G.3
-
25
-
-
0038281249
-
Phosphoinositide recognition domains
-
Lemmon MA Phosphoinositide recognition domains. Traffic 2003, 4:201.
-
(2003)
Traffic
, vol.4
, pp. 201
-
-
Lemmon, M.A.1
-
26
-
-
6344229320
-
Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains
-
Cronin TC, DiNitto JP, Czech MP, et al. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J 2004, 23:3711.
-
(2004)
EMBO J
, vol.23
, pp. 3711
-
-
Cronin, T.C.1
di Nitto, J.P.2
Czech, M.P.3
-
27
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC The phosphoinositide 3-kinase pathway. Science 2002, 296:1655.
-
(2002)
Science
, vol.296
, pp. 1655
-
-
Cantley, L.C.1
-
28
-
-
0031457622
-
Signaling through scaffold, anchoring, and adaptor proteins
-
Pawson T, Scott JD Signaling through scaffold, anchoring, and adaptor proteins. Science 1997, 278:2075.
-
(1997)
Science
, vol.278
, pp. 2075
-
-
Pawson, T.1
Scott, J.D.2
-
29
-
-
0036604986
-
Scaffolds, adaptors and linkers of TCR signaling: Theory and practice
-
Burack WR, Cheng AM, Shaw AS Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol 2002, 14:312.
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 312
-
-
Burack, W.R.1
Cheng, A.M.2
Shaw, A.S.3
-
30
-
-
33746363486
-
Domains, motifs, and scaffolds: The role of modular interactions in the evolution and wiring of cell signaling circuits
-
Bhattacharyya RP, Remenyi A, Yeh BJ, et al. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem 2006, 75:655.
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 655
-
-
Bhattacharyya, R.P.1
Remenyi, A.2
Yeh, B.J.3
-
31
-
-
0344393408
-
Regulation of MAP kianse signaling modules by scaffold proteins in mammals
-
Morrison DK, Davis RJ Regulation of MAP kianse signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003, 19:91.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 91
-
-
Morrison, D.K.1
Davis, R.J.2
-
32
-
-
10044253425
-
AKAP signaling complexes: Focal points in space and time
-
Wong W, Scott JD AKAP signaling complexes: focal points in space and time. Nat Rev Mol Cell Biol 2004, 5:959.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 959
-
-
Wong, W.1
Scott, J.D.2
-
33
-
-
25644452031
-
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
-
Dodge-Kafka KL, Soughayer J, Pare GC, et al. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 2005, 437:574.
-
(2005)
Nature
, vol.437
, pp. 574
-
-
Dodge-Kafka, K.L.1
Soughayer, J.2
Pare, G.C.3
-
35
-
-
0026079628
-
The biochemistry of ras p21
-
Grand RJ, Owen D The biochemistry of ras p21. Biochem J 1991, 279:609.
-
(1991)
Biochem J
, vol.279
, pp. 609
-
-
Grand, R.J.1
Owen, D.2
-
36
-
-
0031687777
-
Signal transduction via Ras
-
Wittinghofer A Signal transduction via Ras. Biol Chem 1998, 379:933.
-
(1998)
Biol Chem
, vol.379
, pp. 933
-
-
Wittinghofer, A.1
-
37
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski MS, McCormick F Proteins regulating Ras and its relatives. Nature 1994, 366:643.
-
(1994)
Nature
, vol.366
, pp. 643
-
-
Boguski, M.S.1
McCormick, F.2
-
39
-
-
0031283407
-
G protein, effectors and GAPs: Structure and mechanism
-
Sprang SR G protein, effectors and GAPs: structure and mechanism. Curr Opin Struct Biol 1997, 7:849.
-
(1997)
Curr Opin Struct Biol
, vol.7
, pp. 849
-
-
Sprang, S.R.1
-
40
-
-
0035292759
-
Themes and variations on ubiquitylation
-
Weissman AM Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2001, 2:169.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 169
-
-
Weissman, A.M.1
-
41
-
-
9744227183
-
Ubiquitin: Structures, functions, mechanisms
-
Pickart CM, Eddins MJ Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 2004, 1695:55.
-
(2004)
Biochim Biophys Acta
, vol.1695
, pp. 55
-
-
Pickart, C.M.1
Eddins, M.J.2
-
42
-
-
0028898424
-
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
-
Scheffner M, Nuber U, Huibregtse JM Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 1995, 373:81.
-
(1995)
Nature
, vol.373
, pp. 81
-
-
Scheffner, M.1
Nuber, U.2
Huibregtse, J.M.3
-
43
-
-
0029036701
-
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
-
Huibregtse JM, Scheffner M, Beaudenon S, et al. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A 1995, 92:5249.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5249
-
-
Huibregtse, J.M.1
Scheffner, M.2
Beaudenon, S.3
-
44
-
-
0034266806
-
RING finger proteins: Mediators of ubiquitin ligase activity
-
Joazeiro CA, Weissman AM RING finger proteins: mediators of ubiquitin ligase activity. Cell 2000, 102:549.
-
(2000)
Cell
, vol.102
, pp. 549
-
-
Joazeiro, C.A.1
Weissman, A.M.2
-
45
-
-
0037756787
-
Structure of a beta-TrCP1-Skp1-beta-catenin complex: Destruction motif binding and lysine specificity of the SCF (beta-TrCP1) ubiquitin ligase
-
Wu G, Xu G, Schulman BA, et al. Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF (beta-TrCP1) ubiquitin ligase. Mol Cell 2003, 11:1445.
-
(2003)
Mol Cell
, vol.11
, pp. 1445
-
-
Wu, G.1
Xu, G.2
Schulman, B.A.3
-
46
-
-
19544375032
-
Wnt control of stem cells and differentiation in the intestinal epithelium
-
Pinto D, Clevers H Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res 2005, 306:357.
-
(2005)
Exp Cell Res
, vol.306
, pp. 357
-
-
Pinto, D.1
Clevers, H.2
-
47
-
-
19644373254
-
Wnt signaling in disease and in development
-
Nusse R Wnt signaling in disease and in development. Cell Res 2005, 15:28.
-
(2005)
Cell Res
, vol.15
, pp. 28
-
-
Nusse, R.1
-
49
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund K, Dikic I Ubiquitylation and cell signaling. EMBO J 2005, 24:3353.
-
(2005)
EMBO J
, vol.24
, pp. 3353
-
-
Haglund, K.1
Dikic, I.2
-
50
-
-
0038394715
-
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
-
Haglund K, Sigismund S, Polo S, et al. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol 2003, 5:461.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 461
-
-
Haglund, K.1
Sigismund, S.2
Polo, S.3
-
51
-
-
33644852909
-
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain
-
Huang F, Kirkpatrick D, Jiang X, et al. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell 2006, 21:737.
-
(2006)
Mol Cell
, vol.21
, pp. 737
-
-
Huang, F.1
Kirkpatrick, D.2
Jiang, X.3
-
53
-
-
0033920919
-
Notch signal transduction: A real rip and more
-
Weinmaster G Notch signal transduction: a real rip and more. Curr Opin Genet Dev 2000, 10:363.
-
(2000)
Curr Opin Genet Dev
, vol.10
, pp. 363
-
-
Weinmaster, G.1
-
54
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
Nakayama KI, Nakayama K Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006, 6:369.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 369
-
-
Nakayama, K.I.1
Nakayama, K.2
-
55
-
-
0026660653
-
Phosphatidylinositol 3?-kinase is activated by association with IRS-1 during insulin stimulation
-
Backer JM, Myers MG, Shoelson SE, et al. Phosphatidylinositol 3?-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 1992, 11:3469.
-
(1992)
EMBO J
, vol.11
, pp. 3469
-
-
Backer, J.M.1
Myers, M.G.2
Shoelson, S.E.3
-
56
-
-
8444224619
-
Balancing Akt with S6K: Implications for both metabolic diseases and turmorigenesis
-
Manning BD Balancing Akt with S6K: implications for both metabolic diseases and turmorigenesis. J Cell Biol 2004, 167:399.
-
(2004)
J Cell Biol
, vol.167
, pp. 399
-
-
Manning, B.D.1
-
57
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3 signaling via regulation of IRS proteins
-
Harrington LS, Findlay GM, Gray A, et al. The TSC1-2 tumor suppressor controls insulin-PI3 signaling via regulation of IRS proteins. J Cell Biol 2004, 166:213.
-
(2004)
J Cell Biol
, vol.166
, pp. 213
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
-
58
-
-
11844304072
-
Restraining PI3K: MTOR signalling goes back to the membrane
-
Harrington LS, Findlay GM, Lamb RF Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem 2005, 30:35.
-
(2005)
Trends Biochem
, vol.30
, pp. 35
-
-
Harrington, L.S.1
Findlay, G.M.2
Lamb, R.F.3
-
59
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase acts as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase acts as a direct target of Ras. Nature 1994, 370:527.
-
(1994)
Nature
, vol.370
, pp. 527
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
-
60
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma L., Chen Z, Erdjument-Bromage H, et al. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179.
-
(2005)
Cell
, vol.121
, pp. 179
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
-
61
-
-
0034614490
-
Signaling-2000 and beyond
-
Hunter T Signaling-2000 and beyond. Cell 2000, 100:113.
-
(2000)
Cell
, vol.100
, pp. 113
-
-
Hunter, T.1
-
62
-
-
0030943398
-
T cell antigen receptor signal transduction
-
Qian D, Weiss A T cell antigen receptor signal transduction. Curr Opin Cell Biol 1997, 9:205.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 205
-
-
Qian, D.1
Weiss, A.2
-
63
-
-
0029896163
-
Regulation, substrates and functions of Src
-
Brown MT, Cooper JA Regulation, substrates and functions of Src. Biochem Biophys Acta 1996, 1287:121.
-
(1996)
Biochem Biophys Acta
, vol.1287
, pp. 121
-
-
Brown, M.T.1
Cooper, J.A.2
-
64
-
-
0001584969
-
The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
-
Smith CI, Islam TC, Mattsson PT, et al. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. BioEssays 2001, 23:436.
-
(2001)
BioEssays
, vol.23
, pp. 436
-
-
Smith, C.I.1
Islam, T.C.2
Mattsson, P.T.3
-
65
-
-
0036731485
-
Stats: Transcriptional control and biological impact
-
Levy DE, Darnell JE Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002, 3:651.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 651
-
-
Levy, D.E.1
Darnell, J.E.2
-
66
-
-
0036391801
-
The Abl family kinases: Mechanisms of regulation and signaling
-
Pendergast AM The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res 2002, 85:51.
-
(2002)
Adv Cancer Res
, vol.85
, pp. 51
-
-
Pendergast, A.M.1
-
67
-
-
3042715237
-
Cell adhesion receptors, tyrosine kinases and actin modulators: A complex three-way circuitry
-
Brunton VG, MacPherson IR, Frame MC Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry. Biochim Biophys Acta 2004, 1692:121.
-
(2004)
Biochim Biophys Acta
, vol.1692
, pp. 121
-
-
Brunton, V.G.1
MacPherson, I.R.2
Frame, M.C.3
-
68
-
-
10744230127
-
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
-
Burgess AW, Cho HS, Eigenbrot KC, et al. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 2003, 12:541.
-
(2003)
Mol Cell
, vol.12
, pp. 541
-
-
Burgess, A.W.1
Cho, H.S.2
Eigenbrot, K.C.3
-
69
-
-
0037145061
-
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
-
Schlessinger J Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 2002, 110:669.
-
(2002)
Cell
, vol.110
, pp. 669
-
-
Schlessinger, J.1
-
71
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/ neu
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/ neu. Science 1987, 235:177.
-
(1987)
Science
, vol.235
, pp. 177
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
72
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams GP, Weiner LM Monoclonal antibody therapy of cancer. Nat Biotechnol 2005, 23:1147.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1147
-
-
Adams, G.P.1
Weiner, L.M.2
-
73
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M, Kuriyan J The conformational plasticity of protein kinases. Cell 2002, 109:275.
-
(2002)
Cell
, vol.109
, pp. 275
-
-
Huse, M.1
Kuriyan, J.2
-
74
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X, Gureasko J, Shen K, et al. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 2006, 125:1137.
-
(2006)
Cell
, vol.125
, pp. 1137
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
-
75
-
-
0344626926
-
Structural basis for the autoinhibition of c-Abl tyrosine kinase
-
Nagar B, Hantschel O, Young MA, et al. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 2003, 112:859.
-
(2003)
Cell
, vol.112
, pp. 859
-
-
Nagar, B.1
Hantschel, O.2
Young, M.A.3
-
76
-
-
14744274624
-
Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
-
Burgess MR, Skaggs BJ, Shah NP, et al. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci U S A 2005, 102:3395.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3395
-
-
Burgess, M.R.1
Skaggs, B.J.2
Shah, N.P.3
-
78
-
-
0028346469
-
SH2 domain specificity and activity modified by a single residue
-
Marengere LEM, Songyang Z, Gish GD, et al. SH2 domain specificity and activity modified by a single residue. Nature 1994, 369:502.
-
(1994)
Nature
, vol.369
, pp. 502
-
-
Marengere, L.E.M.1
Songyang, Z.2
Gish, G.D.3
-
79
-
-
0035930341
-
Mutation of the c-Cbl TKB domain binding site of the Met receptor tyrosine kinase converts it into a transforming protein
-
Peschard P, Fournier TM, Lamorte L, et al. Mutation of the c-Cbl TKB domain binding site of the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 2001, 8:995.
-
(2001)
Mol Cell
, vol.8
, pp. 995
-
-
Peschard, P.1
Fournier, T.M.2
Lamorte, L.3
-
80
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 2006, 66:283.
-
(2006)
Cancer Res
, vol.66
, pp. 283
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
-
81
-
-
0031918624
-
The IRS-signalling system: A network of docking proteins that mediate insulin action
-
White MF The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 1998, 182:3.
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 3
-
-
White, M.F.1
-
82
-
-
0026544517
-
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation
-
Backer JM, Schroeder GG, Kahn CR, et al. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J Biol Chem 1992, 267:1367.
-
(1992)
J Biol Chem
, vol.267
, pp. 1367
-
-
Backer, J.M.1
Schroeder, G.G.2
Kahn, C.R.3
-
83
-
-
0027437376
-
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
-
Sun XJ, Crimmins DL, Myers MG, et al. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 1993, 13:7418.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7418
-
-
Sun, X.J.1
Crimmins, D.L.2
Myers, M.G.3
-
84
-
-
0028874953
-
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities
-
Wolf G, Trub T, Ottinger E, et al. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem 1995, 270:27407-27410.
-
(1995)
J Biol Chem
, vol.270
, pp. 27407-27410
-
-
Wolf, G.1
Trub, T.2
Ottinger, E.3
-
85
-
-
0030175744
-
Regulation of antigen receptor signal transduction by protein tyrosine kinases
-
Chan AC, Shaw AS Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr Opin Immunol 1996, 8:394.
-
(1996)
Curr Opin Immunol
, vol.8
, pp. 394
-
-
Chan, A.C.1
Shaw, A.S.2
-
86
-
-
0029031806
-
Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins
-
Neumeister EN, Zhu Y, Richard S, et al. Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol Cell Biol 1995, 15:3171.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3171
-
-
Neumeister, E.N.1
Zhu, Y.2
Richard, S.3
-
87
-
-
0028926070
-
Transmembrane signaling by antigen receptors of B and T lymphocytes
-
DeFranco AL Transmembrane signaling by antigen receptors of B and T lymphocytes. Curr Opin Cell Biol 1995, 7:163.
-
(1995)
Curr Opin Cell Biol
, vol.7
, pp. 163
-
-
de Franco, A.L.1
-
88
-
-
0028269436
-
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase
-
Arpaia E, Shahar M, Dadi H, et al. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell 1994, 76:947.
-
(1994)
Cell
, vol.76
, pp. 947
-
-
Arpaia, E.1
Shahar, M.2
Dadi, H.3
-
89
-
-
0028292001
-
Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
-
Elder ME, Lin D, Clever J, et al. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994, 264:1596.
-
(1994)
Science
, vol.264
, pp. 1596
-
-
Elder, M.E.1
Lin, D.2
Clever, J.3
-
90
-
-
0345414139
-
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
-
Sakaguchi N, Takahashi T, Hata H, et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003, 426:454.
-
(2003)
Nature
, vol.426
, pp. 454
-
-
Sakaguchi, N.1
Takahashi, T.2
Hata, H.3
-
91
-
-
0015694748
-
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973, 243:290.
-
(1973)
Nature
, vol.243
, pp. 290
-
-
Rowley, J.D.1
-
92
-
-
2542441665
-
The BCR-ABL story: Bench to bedside and back
-
Wong S, Witte ON The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 2004, 22:247.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 247
-
-
Wong, S.1
Witte, O.N.2
-
93
-
-
0027422977
-
A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins
-
McWhirter JR, Galasso DL, Wang JY A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol Cell Biol 1993, 13:7587.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7587
-
-
McWhirter, J.R.1
Galasso, D.L.2
Wang, J.Y.3
-
94
-
-
0028147448
-
BCR-ABL oncoproteins bind directly to activators of the ras signalling pathway
-
Puil L, Liu X, Gish G, et al. BCR-ABL oncoproteins bind directly to activators of the ras signalling pathway. EMBO J 1994, 13:764.
-
(1994)
EMBO J
, vol.13
, pp. 764
-
-
Puil, L.1
Liu, X.2
Gish, G.3
-
95
-
-
0027368352
-
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
-
Pendergast AM, Quilliam LA, Cripe LD, et al. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993, 75:175.
-
(1993)
Cell
, vol.75
, pp. 175
-
-
Pendergast, A.M.1
Quilliam, L.A.2
Cripe, L.D.3
-
96
-
-
0028964465
-
Cytokine signaling through nonreceptor protein tyrosine kinases
-
Taniguchi T Cytokine signaling through nonreceptor protein tyrosine kinases. Science 1995, 268:251.
-
(1995)
Science
, vol.268
, pp. 251
-
-
Taniguchi, T.1
-
97
-
-
0028234529
-
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell JE, Kerr IM, Stark GR Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415.
-
(1994)
Science
, vol.264
, pp. 1415
-
-
Darnell, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
98
-
-
7944233465
-
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
-
Silva CM Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004, 23:8017.
-
(2004)
Oncogene
, vol.23
, pp. 8017
-
-
Silva, C.M.1
-
99
-
-
0032577678
-
Crystal structure of tyrosine phosphorylated STAT-1 dimer bound to DNA
-
Chen X, Vinkemeier U, Zhao Y, et al. Crystal structure of tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 1998, 93:827.
-
(1998)
Cell
, vol.93
, pp. 827
-
-
Chen, X.1
Vinkemeier, U.2
Zhao, Y.3
-
100
-
-
20144376462
-
Structural basis of unphosphorylated STAT1 association and receptor binding
-
Mao X, Ren Z, Parker GN, et al. Structural basis of unphosphorylated STAT1 association and receptor binding. Mol Cell 2005, 17:761.
-
(2005)
Mol Cell
, vol.17
, pp. 761
-
-
Mao, X.1
Ren, Z.2
Parker, G.N.3
-
101
-
-
0347093460
-
Inhibitors of cytokine signal transduction
-
Wormald S, Hilton DJ Inhibitors of cytokine signal transduction. J Biol Chem 2004, 279:821.
-
(2004)
J Biol Chem
, vol.279
, pp. 821
-
-
Wormald, S.1
Hilton, D.J.2
-
102
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434:1144.
-
(2005)
Nature
, vol.434
, pp. 1144
-
-
James, C.1
Ugo, V.2
le Couedic, J.P.3
-
103
-
-
17444377587
-
JAKing up hematopoietic proliferation
-
Shannon K, Van Etten RA JAKing up hematopoietic proliferation. Cancer Cell 2005, 7:291.
-
(2005)
Cancer Cell
, vol.7
, pp. 291
-
-
Shannon, K.1
van Etten, R.A.2
-
104
-
-
2942530310
-
ERK and p38 MAPK-activated kinases: A family of protein kinases with diverse biological functions
-
Roux PP, Blenis J ERK and p38 MAPK-activated kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004, 68:320.
-
(2004)
Microbiol Mol Biol Rev
, vol.68
, pp. 320
-
-
Roux, P.P.1
Blenis, J.2
-
105
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch W Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000, 351:289.
-
(2000)
Biochem J
, vol.351
, pp. 289
-
-
Kolch, W.1
-
106
-
-
0032422785
-
Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
-
Whitmarsh AJ, Davis RJ Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci 1998, 23:481.
-
(1998)
Trends Biochem Sci
, vol.23
, pp. 481
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
107
-
-
0027294981
-
The SH2 and SH3 domains of mammalian Grb2 couple the EGF-receptor to mSos1, an activator of Ras
-
Rozakis-Adcock M, Fernley R, Wade J, et al. The SH2 and SH3 domains of mammalian Grb2 couple the EGF-receptor to mSos1, an activator of Ras. Nature 1993, 363:83.
-
(1993)
Nature
, vol.363
, pp. 83
-
-
Rozakis-Adcock, M.1
Fernley, R.2
Wade, J.3
-
108
-
-
0027312272
-
Guanine nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling
-
Li N, Batzer A, Daly R, et al. Guanine nucleotide releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling. Nature 1993, 363:85.
-
(1993)
Nature
, vol.363
, pp. 85
-
-
Li, N.1
Batzer, A.2
Daly, R.3
-
109
-
-
0344885558
-
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit SM, Sondermann H, Hall BE, et al. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003, 112:685.
-
(2003)
Cell
, vol.112
, pp. 685
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
-
110
-
-
0030250003
-
Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins
-
Resh MD Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins. Cell Signal 1996, 8:403.
-
(1996)
Cell Signal
, vol.8
, pp. 403
-
-
Resh, M.D.1
-
111
-
-
0025740753
-
The structure of Ras protein: A model for a universal molecular switch
-
Wittinghofer A, Pai EF The structure of Ras protein: a model for a universal molecular switch. Trends Biochem Sci 1991, 16:382.
-
(1991)
Trends Biochem Sci
, vol.16
, pp. 382
-
-
Wittinghofer, A.1
Pai, E.F.2
-
113
-
-
0030464444
-
How Ras-related proteins talk to their effectors
-
Wittinghofer A, Nassar N How Ras-related proteins talk to their effectors. Trends Biochem Sci 1996, 21:488.
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 488
-
-
Wittinghofer, A.1
Nassar, N.2
-
114
-
-
0027935756
-
Interaction of Ras and Raf in intact mammalian cell upon extracellular stimulation
-
Hallberg B, Rayter SI, Downward J Interaction of Ras and Raf in intact mammalian cell upon extracellular stimulation. J Biol Chem 1994, 269:3913.
-
(1994)
J Biol Chem
, vol.269
, pp. 3913
-
-
Hallberg, B.1
Rayter, S.I.2
Downward, J.3
-
115
-
-
0037400510
-
Mechanisms of regulating the Raf kinase family
-
Chong H, Vikis HG, Guan KL Mechanisms of regulating the Raf kinase family. Cell Signal 2003, 15:463.
-
(2003)
Cell Signal
, vol.15
, pp. 463
-
-
Chong, H.1
Vikis, H.G.2
Guan, K.L.3
-
117
-
-
0035898539
-
Positive and negative regulation of Raf kinase activity and function by phosphorylation
-
Chong H, Lee J, Guan KL Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO J 2001, 20:3716.
-
(2001)
EMBO J
, vol.20
, pp. 3716
-
-
Chong, H.1
Lee, J.2
Guan, K.L.3
-
118
-
-
0034698027
-
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation
-
Abraham D, Podar K, Pacher M, et al. Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. J Biol Chem 2000, 275:22300-22304.
-
(2000)
J Biol Chem
, vol.275
, pp. 22300-22304
-
-
Abraham, D.1
Podar, K.2
Pacher, M.3
-
119
-
-
0035811597
-
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
-
Jaumot M, Hancock JF Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 2001, 20:3949.
-
(2001)
Oncogene
, vol.20
, pp. 3949
-
-
Jaumot, M.1
Hancock, J.F.2
-
120
-
-
0035018017
-
KSR, a MAPK scaffold of the Ras pathway
-
Morrison DK KSR, a MAPK scaffold of the Ras pathway. J Cell Sci 2001, 114:1609.
-
(2001)
J Cell Sci
, vol.114
, pp. 1609
-
-
Morrison, D.K.1
-
121
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005, 6:827.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 827
-
-
Kolch, W.1
-
122
-
-
0033561041
-
Serine and tyrosine phosphorylation cooperate in Raf-1, but not B-Raf activation
-
Mason CS, Springer CJ, Cooper RG, et al. Serine and tyrosine phosphorylation cooperate in Raf-1, but not B-Raf activation. EMBO J 1999, 18:2137.
-
(1999)
EMBO J
, vol.18
, pp. 2137
-
-
Mason, C.S.1
Springer, C.J.2
Cooper, R.G.3
-
124
-
-
0037400611
-
Molecular recognitions in the MAP kinase cascades
-
Tanoue T, Nishida E Molecular recognitions in the MAP kinase cascades. Cell Signal 2003, 15:455.
-
(2003)
Cell Signal
, vol.15
, pp. 455
-
-
Tanoue, T.1
Nishida, E.2
-
125
-
-
0033788484
-
A conserved docking motif in MAP kinases common to substrates, activators and regulators
-
Tanoue T, Adachi M, Moriguchi T, et al. A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat Cell Biol 2000, 2:110.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 110
-
-
Tanoue, T.1
Adachi, M.2
Moriguchi, T.3
-
126
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003, 3:11.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11
-
-
Downward, J.1
-
127
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949.
-
(2002)
Nature
, vol.417
, pp. 949
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
128
-
-
0025285159
-
Ras oncogenes: Their role in neoplasia
-
Barbacid M Ras oncogenes: their role in neoplasia. Eur J Clin Invest 1990, 20:225.
-
(1990)
Eur J Clin Invest
, vol.20
, pp. 225
-
-
Barbacid, M.1
-
129
-
-
0035936783
-
NF1 tumor suppressor gene function: Narrowing the GAP
-
Cichowski K, Jacks T NF1 tumor suppressor gene function: narrowing the GAP. Cell 2001, 104:593.
-
(2001)
Cell
, vol.104
, pp. 593
-
-
Cichowski, K.1
Jacks, T.2
-
130
-
-
12144289677
-
Cancer Genome Project: Mechanism of activation of the RAF-ERK signaling pathway by oncogenic muations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, et al. Cancer Genome Project: Mechanism of activation of the RAF-ERK signaling pathway by oncogenic muations of B-RAF. Cell 2004, 116:855.
-
(2004)
Cell
, vol.116
, pp. 855
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
-
131
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
Garnett MJ, Rana S, Paterson H, et al. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 2005, 20:963.
-
(2005)
Mol Cell
, vol.20
, pp. 963
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
-
132
-
-
2442689239
-
Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
-
Rodriguez-Viciana P, Sabatier C, et al. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 2004, 24:4943.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 4943
-
-
Rodriguez-Viciana, P.1
Sabatier, C.2
-
133
-
-
17644408725
-
RalGDS is required for tumor formation in a model of skin carcinogenesis
-
Gonzales-Garcia A, Pritchard CA, Paterson HF, et al. RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell 2005, 7:219.
-
(2005)
Cancer Cell
, vol.7
, pp. 219
-
-
Gonzales-Garcia, A.1
Pritchard, C.A.2
Paterson, H.F.3
-
134
-
-
10844263476
-
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development
-
Bai Y, Edamatsu H, Maeda S, et al. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res 2004, 64:8808.
-
(2004)
Cancer Res
, vol.64
, pp. 8808
-
-
Bai, Y.1
Edamatsu, H.2
Maeda, S.3
-
135
-
-
0037142034
-
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
-
Malliri A, van der Kammen RA, Clark K, et al. Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 2002, 417:867.
-
(2002)
Nature
, vol.417
, pp. 867
-
-
Malliri, A.1
van der Kammen, R.A.2
Clark, K.3
-
136
-
-
0027403027
-
SH2 domains recognize specific phosphopeptide squences
-
Songyang Z, Shoelson SE, Chaudhuri M, et al. SH2 domains recognize specific phosphopeptide squences. Cell 1993, 72:767.
-
(1993)
Cell
, vol.72
, pp. 767
-
-
Songyang, Z.1
Shoelson, S.E.2
Chaudhuri, M.3
-
137
-
-
0032514801
-
Regulation of the p85/p110a phosphatidylinositol 3?-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains
-
Yu J, Wiasow C, Backer JM Regulation of the p85/p110a phosphatidylinositol 3?-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains. J Biol Chem 1998, 273:30199-30203.
-
(1998)
J Biol Chem
, vol.273
, pp. 30199-30203
-
-
Yu, J.1
Wiasow, C.2
Backer, J.M.3
-
138
-
-
0031887249
-
Regulation of the p85/p110 phosphatidylinositol 3?-kinase:stabilization and inhibition of the p110a catalytic subunit by the p85 regulatory subunit
-
Yu J, Zhang Y, McIlroy J, et al. Regulation of the p85/p110 phosphatidylinositol 3?-kinase:stabilization and inhibition of the p110a catalytic subunit by the p85 regulatory subunit. Mol Cell Biol 1998, 18:1379.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1379
-
-
Yu, J.1
Zhang, Y.2
McIlroy, J.3
-
139
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998, 273:13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
140
-
-
1542569606
-
Membrane recognition and targeting by lipid-binding domains
-
DiNitto JP, Cronin TC, Lambright DG Membrane recognition and targeting by lipid-binding domains. Science 2003, re16.
-
(2003)
Science
, pp. re16
-
-
di Nitto, J.P.1
Cronin, T.C.2
Lambright, D.G.3
-
141
-
-
0037162293
-
High-resolution structure of the pleckstrin homology domain of protein kinase B/akt bound to phosphatidylinositol (3,4,5)-trisphosphate
-
Thomas CC, Deak M, Alessi DR, et al. High-resolution structure of the pleckstrin homology domain of protein kinase B/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol 2002, 12:1256.
-
(2002)
Curr Biol
, vol.12
, pp. 1256
-
-
Thomas, C.C.1
Deak, M.2
Alessi, D.R.3
-
142
-
-
0029993517
-
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation
-
James SR, Downes CP, Gigg R, et al. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem J 1996, 315:709.
-
(1996)
Biochem J
, vol.315
, pp. 709
-
-
James, S.R.1
Downes, C.P.2
Gigg, R.3
-
143
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 1997, 7:261.
-
(1997)
Curr Biol
, vol.7
, pp. 261
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
-
144
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997, 277:567.
-
(1997)
Science
, vol.277
, pp. 567
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
-
145
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098.
-
(2005)
Science
, vol.307
, pp. 1098
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
146
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002, 4:648.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
-
147
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter CJ, Pedraza LG, Xu T Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002, 4:658.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 658
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
148
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning BD, Tee AR, Logsdon MN, et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002, 10:151.
-
(2002)
Mol Cell
, vol.10
, pp. 151
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
-
149
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoli K, Zhu T, Guan KL TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577.
-
(2003)
Cell
, vol.115
, pp. 577
-
-
Inoli, K.1
Zhu, T.2
Guan, K.L.3
-
150
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN TOR signaling in growth and metabolism. Cell 2006, 124:471.
-
(2006)
Cell
, vol.124
, pp. 471
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
151
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar DC, Salama S, Tsou C, et al. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002, 16:1472.
-
(2002)
Genes Dev
, vol.16
, pp. 1472
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
-
152
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N Upstream and downstream of mTOR. Genes Dev 2004, 18:1926.
-
(2004)
Genes Dev
, vol.18
, pp. 1926
-
-
Hay, N.1
Sonenberg, N.2
-
153
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
154
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231.
-
(1997)
Cell
, vol.91
, pp. 231
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
155
-
-
1842333237
-
Interleukin-3-indeuced phosphorylation of BAD through the protein kinase Akt
-
del Peso L, Gonzales-Garcia M, Page C, et al. Interleukin-3-indeuced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278:687.
-
(1997)
Science
, vol.278
, pp. 687
-
-
del Peso, L.1
Gonzales-Garcia, M.2
Page, C.3
-
157
-
-
0032533225
-
Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization
-
Diehl JA, Cheng M, Roussel MF, et al. Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998, 12:3499.
-
(1998)
Genes Dev
, vol.12
, pp. 3499
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
-
158
-
-
0034306997
-
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
-
Sears R, Nuckolls F, Haura E, et al. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000, 14:2501.
-
(2000)
Genes Dev
, vol.14
, pp. 2501
-
-
Sears, R.1
Nuckolls, F.2
Haura, E.3
-
159
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
Luo J, Manning BD, Cantley LC Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003, 4:257.
-
(2003)
Cancer Cell
, vol.4
, pp. 257
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
160
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
161
-
-
33745307617
-
Ras,PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ Cantley LC. Ras,PI(3)K and mTOR signalling controls tumour cell growth. Nature 20606;441:424 .
-
(2006)
Nature
, vol.441
, pp. 424
-
-
Shaw, R.J.1
Cantley, LC.2
|