Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

Nature

Volumn 417, Issue 6891, 2002, Pages 867-871

  Malliri, Angeliki ^a   Van der Kammen, Rob A ^a   Clark, Kristopher ^a   Van der Valk, Maarten ^a   Michiels, Frits ^b   Collard, John G ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Galapagos Genomics   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GENES; ORGANIC ACIDS; TUMORS;

ACTIN CUTOSKELETON;

DERMATITIS;

7,12 DIMETHYLBENZ[A]ANTHRACENE; ACTIN; GUANOSINE TRIPHOSPHATASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN TIAM1; RAC PROTEIN; RAS PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

MEDICINE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; GENE DOSAGE; GENE MUTATION; GENETIC TRANSCRIPTION; HETEROZYGOSITY; LYMPHOMA; MALIGNANT TRANSFORMATION; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APOPTOSIS; CELL DIVISION; DISEASE PROGRESSION; GENE DOSAGE; GENOTYPE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IMMUNOHISTOCHEMISTRY; KERATINS; MICE; MICE, KNOCKOUT; PROTEINS; RAS PROTEINS; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0037142034     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00848     Document Type: Article

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